cancer stem cells

[Clinical Epigenetics] Ten–eleven translocation methylcytosine dioxygenase 1 (TET1) is involved in DNA demethylation and transcriptional regulation, plays a key role in the maintenance of stem cell pluripotency, and is dysregulated in malignant cells. Researchers analyzed TET1 expression in prostate cancer.

[Seminars in Cancer Biology] Scientists discuss prostate cancer (PCa) from the perspective of an abnormal organ development and deregulated cellular differentiation, and discuss the luminal progenitor cells as the likely cells of origin for PCa.

[Lab On A Chip] Investigators developed a microfluidic organ-on-chip platform for matrix-based, heterogeneous 3D cultures with fully integrated electrochemical chemo- and biosensor arrays for the energy metabolites oxygen, lactate, and glucose.

[Nature Cell Biology] Scientists showed that Cldn18 tumors accurately recapitulated advanced human gastric cancer in terms of disease morphology, aberrant gene expression, molecular markers and sites of distant metastases.

[Hepatology International] Therapy of umbilical cord-derived MSC was not only well tolerated, but also significantly improved long-term survival rate, as well as the liver function in patients with Hepatits B Virus-related decompensated liver cirrhosis.

[Ottawa Citizen] Each year, the Ottawa Hospital honours three outstanding researchers for discoveries that are having an impact around the world. This year’s honourees have led game-changing discoveries and clinical trials in areas such as ovarian cancer, stem cells and blood transfusions.