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cancer stem cells

Differential Phase Register of Hes1 Oscillations with Mitoses Underlies Cell-Cycle Heterogeneity in ER+ Breast Cancer Cells

[Proceedings of the National Academy of Sciences of the United States of America] Scientists studied the dynamical expression of endogenously labeled Hes1, a transcriptional repressor implicated in controlling cell proliferation, to understand how cell-cycle length heterogeneity was generated in estrogen receptor (ER)+ breast cancer cells.

Fasting-Mimicking Diet Blocks Triple-Negative Breast Cancer and Cancer Stem Cell Escape

[Cell Metabolism] The authors reported that a fasting-mimicking diet activated starvation escape pathways in TNBC cells, which could be identified and targeted by drugs. They found that metastatic TNBC patients with lower glycemia survived longer than those with higher baseline glycemia.

HIF-1–Regulated Expression of Calreticulin Promotes Breast Tumorigenesis and Progression through Wnt/β-Catenin Pathway Activation

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrated that calreticulin facilitated breast cancer progression by promoting the breast cancer stem cell phenotype through Wnt/β-catenin signaling in a hypoxia-inducible factor 1 (HIF-1)–dependent manner.

N1-Methyladenosine Methylation in tRNA Drives Liver Tumorigenesis by Regulating Cholesterol Metabolism

[Nature Communications] Investigators showed that N1-methyladenosine methylation in tRNA was remarkably elevated in hepatocellular carcinoma patient tumor tissues.

Single-Cell RNA Sequencing Reveals the Epithelial Cell Heterogeneity and Invasive Subpopulation in Human Bladder Cancer

[International Journal of Cancer] Investigators applied droplet-based single-cell RNA sequencing (scRNA-seq) to acquire transcriptional profiles of 36 619 single cells isolated from seven patients.

SOX12 Promotes Stem Cell-Like Phenotypes and Osteosarcoma Tumor Growth by Upregulating JAGGED1

[Stem Cells International] SOX12 plays a role in promoting the growth of some tumors; however, its role in osteosarcoma remains unclear. Researchers performed in vitro and in vivo assays to determine SOX12 function in osteosarcoma etiology.

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