JAM-A Functions as a Female Microglial Tumor Suppressor in Glioblastoma

Investigators studied the role of microenvironmental junctional adhesion molecule-A (JAM-A) in mediating glioblastoma growth.
[Neuro-Oncology]
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Protein Sumoylation with SUMO1 Promoted by Pin1 in Glioma Stem Cells Augments Glioblastoma Malignancy

Researchers investigated the protein sumoylation status, the major sumoylated substrate and the key regulatory enzyme in glioma stem cells to explore the therapeutic potential of disrupting protein sumoylation for glioblastoma treatment.
[Neuro-Oncology]
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Radiotherapy Targeting Cancer Stem Cells “Awakens” Them to Induce Tumor Relapse and Metastasis in Oral Cancer

Researchers summarzse methods for the identification of oral CSCs and then focus on the characteristics of a CSC subpopulation induced by radiation, hereafter referred to as “awakened” CSCs, to highlight their response to radiotherapy and potential role in tumor recurrence and metastasis post-radiotherapy as well as potential therapeutics targeting CSCs.
[International Journal of Oral Science]
Liu, Y., Yang, M., Luo, J., & Zhou, H. (2020). Radiotherapy targeting cancer stem cells “awakens” them to induce tumour relapse and metastasis in oral cancer. International Journal of Oral Science, 12(1), 1–12. https://doi.org/10.1038/s41368-020-00087-0 Cite
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Cytochrome P450 1B1 Polymorphism Drives Cancer Cell Stemness and Patient Outcome in Head-and-Neck Carcinoma

From head-and-neck squamous cell carcinoma cell lines not expressing CYP1B1, investigators generated isogenic derivatives expressing the two forms. Proliferation, invasiveness, stem cell characteristics, sensitivity to anticancer agents and transcriptome were analyzed.
[British Journal of Cancer]
Morvan, V. L., Richard, É., Cadars, M., Fessart, D., Broca-Brisson, L., Auzanneau, C., Pasquies, A., Modesto, A., Lusque, A., Mathoulin-Pélissier, S., Lansiaux, A., & Robert, J. (2020). Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-020-0932-5 Cite
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Signaling Inhibitors Accelerate the Conversion of Mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports]

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Isoprenylcysteine Carboxylmethyltransferase Is Required for the Impact of Mutant KRAS on TAZ Protein Level and Cancer Cell Self-Renewal

The authors found that suppression of isoprenylcysteine carboxylmethyltransferase resulted in reduced self-renewal/stemness in KRAS-driven pancreatic and breast cancer cells.
[Oncogene]
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Targeting Lung Cancer Stem Cells Using Combination of Tel and Docetaxel Liposomes in 3D Cultures and Tumor Xenografts

Scientists demonstrated for the first time the efficacy of Docetaxel liposomes in combination with telmisartan in 3D cultures of H460 cells by using polysaccharide-based hydrogels and also in xenograft model of Docetaxel resistant H460 derived CD133+ lung tumors.
[Toxicology and Applied Pharmacology]
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Cancer Stem Cells in Soft-Tissue Sarcomas

The authors review the published evidence of cancer stem cells (CSCs) in soft tissue sarcoma (STS), discussing the molecular characteristic of CSCs, the commonly used isolation techniques and the new possibilities of targeting CSCs as a way to improve STS treatment and consequently patient outcome.
[Cells]
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A Positive Feedback Loop between c-Myc Up-Regulation, Glycolytic Shift and Histone Acetylation Enhances Cancer Stem Cell-Like Property and Tumorigenicity of Cr(VI)-Transformed Cells

Researchers investigated the potential role and mechanism of metabolism dysregulation in chronic hexavalent chromium [Cr(VI)] carcinogenesis. It was found that Cr(VI)-transformed cells displayed glycolytic shift, which depends on the up-regulation of c-Myc.
[Toxicological Sciences]
Clementino, M., Xie, J., Yang, P., Li, Y., Lin, H.-P., Fenske, W. K., Tao, H., Kondo, K., Yang, C., & Wang, Z. (n.d.). A positive feedback loop between c-Myc up-regulation, glycolytic shift and histone acetylation enhances cancer stem cell-like property and tumorigenicity of Cr(VI)-transformed cells. Toxicological Sciences. https://doi.org/10.1093/toxsci/kfaa086 Cite
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Ibuprofen Mediates Histone Modification to Diminish Cancer Cell Stemness Properties via a COX2-Dependent Manner

The authors report that ibuprofen diminished cancer cell stemness properties that include reducing the ALDH+ subpopulation, side population and sphere formation in three cancer types.
[British Journal of Cancer]
Shen, W., Zhang, X., Du, R., Gao, W., Wang, J., Bao, Y., Yang, W., Luo, N., & Li, J. (2020). Ibuprofen mediates histone modification to diminish cancer cell stemness properties via a COX2-dependent manner. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-0906-7 Cite
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Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

Scientists identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, suppressed SCLC expansion in culture and in vivo.
[Cancer Cell]
Coles, G. L., Cristea, S., Webber, J. T., Levin, R. S., Moss, S. M., He, A., Sangodkar, J., Hwang, Y. C., Arand, J., Drainas, A. P., Mooney, N. A., Demeter, J., Spradlin, J. N., Mauch, B., Le, V., Shue, Y. T., Ko, J. H., Lee, M. C., Kong, C., … Sage, J. (2020). Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.05.003 Cite
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