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cancer stem cells

Integrins Regulate Stemness in Solid Tumor: An Emerging Therapeutic Target

[Journal of Hematology & Oncology] Scientists discuss the integrin signalosome with a highlight of a few key pro-oncogenic pathways elicited by integrins, and uncover the mutational and transcriptomic landscape of integrin-encoding genes across human cancers.

LncRNA ASAP1-IT1 Enhances Cancer Cell Stemness via Regulating miR-509-3p/YAP1 Axis in NSCLC

[Cancer Cell International] The authors investigated the role of ASAP1 Intronic Transcript 1 (ASAP1-IT1) in cancer cell stemness of non-small cell lung cancer.

Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow

[Journal of Histochemistry & Cytochemistry] Scientists review recent literature on energy production in glioblastoma stem cells and leukemic stem cells versus their normal counterparts, neural stem cells and hematopoietic stem cells, respectively.

Stemness and Immune Evasion Conferred by TDO2-AHR Pathway Are Associated with Liver Metastasis of Colon Cancer

[Cancer Science] Scientists carried out systematic analyses of metabolites in patient-derived colorectal cancer spheroids, and identified high levels of kynurenine and TDO2 that were positively associated with liver metastasis.

Three-Dimensional Organoid Culture Unveils Resistance to Clinical Therapies in Adult and Pediatric Glioblastoma

[Translational Oncology] Scientists created organoid microarrays and visualized bulk and spatial differences in cell proliferation using immunohistochemistry staining, and cell cycle analysis by flow cytometry paired with 3D regional labeling.

Heterogeneity of Subsets in Glioblastoma Mediated by Smad3 Palmitoylation

[Oncogenesis] A mutation in isocitrate dehydrogenase 1 was found to suppress the transforming growth factor-beta signaling pathway and E2F4 interacted with Smad3 to inhibit expression of mesenchymal markers.

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