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cancer stem cells

Suppressive Effect of α-Mangostin for Cancer Stem Cells in Colorectal Cancer via the Notch Pathway

[BMC Cancer] Scientists evaluated the selective inhibition of α-mangostin on CSCs in colorectal cancer and the suppressive effect on 5-fluorouracil-induced CSCs.

Exosomal DEK Removes Chemoradiotherapy Resistance by Triggering Quiescence Exit of Breast Cancer Stem Cells

[Oncogene] Researchers identified and isolated chemoradiotherapy-resistant cancer stem cells in quiescent state with high capacity of tumor-initiation and tumorsphere formation from three types of breast tumors in mice.

A Bioinspired Redox-Modulating Copper(ii)–Macrocyclic Complex Bearing Non-steroidal Anti-inflammatory Drugs with Anti-Cancer Stem Cell Activity

[Dalton Transactions] Investigators reported a biologically stable copper(II) complex based on the active site of Type I copper electron transport proteins.

Forces in Stem Cells and Cancer Stem Cells

[Stem Cells and Development] The authors review advances in understanding the impact of forces and mechanics on functions and fate of embryonic stem cells, adult stem cells, and cancer stem cells and the pathways of mechanotransduction in cells.

Cancer Stem Cell Markers for Urinary Carcinoma

[Stem Cells International] At present, the isolation and identification of cancer stem cells from many solid tumors are still quite difficult, mainly due to the lack of specific molecular markers of cancer stem cells.

Trefoil Factor 3 Promotes Pancreatic Carcinoma Progression via WNT Pathway Activation Mediated by Enhanced WNT Ligand Expression

[Cell Death & Disease] Researchers observed that trefoil factor 3 (TFF3) expression was elevated in PDAC, and was positively correlated with a worse overall patient survival outcome.

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