cancer stem cells

[PLOS One] Investigators investigated whether KH176m, a recently discovered selective mPGES-1 inhibitor, could affect prostate cancer cells-derived spheroid growth.

[British Journal of Cancer] Scientists identified the consistent transcriptome of primary breast cancer stem cells (BCSCs) shared across breast cancer subtypes, and examined the clinical relevance of ITGA7, one of the genes differentially expressed in BCSCs.

[Nature Communications] The authors demonstrated that coordinated regulation of both isoforms through control of splicing was essential for development of Kras mutant tumors. The minor KRAS4A isoform was enriched in cancer stem-like cells, where it responded to hypoxia, while the major KRAS4B was induced by ER stress.

[British Journal of Cancer] The authors identified homeobox B9 (HOXB9) as a critical regulator of metastatic metastatic prostate CSCs behavior.

[ACS Applied Materials & Interfaces] Researchers established a niche for glioblastoma stem-like cell selection as a platform and facilitate the assessment of differentiation therapy on glioblastoma multiforme cancer stem-like colonies by retinoic acid with temozolomide-loaded gold nanoparticles associated with low-intensity ultrasound.

[Cell Death Discovery] The roles of small extracellular vesicles (sEVs) from cancer-associated fibroblasts on breast cancer stem cell properties are largely unraveled. Investigators explored the roles of sEVs from cancer-associated fibroblasts on breast cancer progression.