cancer stem cells

[Communications Biology] Researchers identified testis-specific Y-like protein 5 (TSPYL5) as an upstream regulator of CSC-associated genes in non-small cell lung cancer cells, and suggested this as a therapeutic target for CSC elimination.

[Nature Communications] Investigators discovered that prohibitin (PHB) specifically regulates mitochondrial ROS production in glioma stem-like cells (GSCs) and facilitates GSC radiotherapeutic resistance.

[Nature Communications] The authors discovered that prohibitin specifically regulated mitochondrial ROS production in glioma stem-like cells (GSCs) and facilitated GSC radiotherapeutic resistance.

[Oncogene] Investigators revealed a role for MUC1-C in regulating PBAF, redox balance and lineage plasticity of prostate cancer stem cell progression.

[Seminars in Cancer Biology] Scientists discuss recent advances in understanding the cell types of origin, putative cancer stem cells, and tumor plasticity in prostate cancer, focusing on insights from studies of genetically engineered mouse models.

[Biomedicine & Pharmacotherapy] The authors point out the dynamic potential of CSCs and other stem cells types in colorectal cancer (CRC) treatment personalization as well as, in the improvement of current treatment approaches, opting to a higher therapeutic rate, improved prognosis, survival and quality of life for CRC patients.