cancer stem cells

[Cancer Research] Using a combination of in vivo and in vitro analyses in a novel PyMT-E2A conditional knockout mouse model and derived primary tumor cell lines, researchers reported an essential role of E2A in stemness, metastasis, and therapeutic resistance in breast cancer.

[Nutrition and Cancer-An International Journal] Scientists evaluated the effects of Bryophytes like Abietinella abietina, Homolothecium sericeum, Tortella tortuosa, Syntrichia ruralis, and Bryoerythrophyllum rubrum species extracted with ethyl alcohol on 5-fluorouracil resistant colorectal cancer cell lines.

[Oral Diseases] Researchers investigated whether lysine-specific demethylase 1 (LSD1) affected the development of oral squamous cell carcinoma (OSCC) by sustaining the CSCs from OSCC.

[Stem Cell Research & Therapy] The authors suggested CSC-derived exo-SNHG16 promoted cancer progression by activating TLR7/MyD88/NFκB/c-Myc signaling pathway.

[Cancer Cell International] Scientists explain the possible mechanism of the Hippo pathway in combating endocrine resistance, and conclude by recommending endocrine therapy in combination with therapies targeting the Hippo pathway in the study of endocrine-resistant breast cancers.

[Stem Cell Reviews and Reports] Scientists discuss the common properties of cancer stem cells (CSCs) and PSCs, and highlight the potential of PSCs in cancer studies, therapeutic applications, as well as educating the immune system against CSCs.