cardiac fibroblasts

[Scientific Reports] Investigators determined the effect of cell type-specific deletion of protease-activated receptor 1 (PAR1) in cardiac myocytes and cardiac fibroblasts on Coxsackievirus B3-induced myocarditis.

[Cell Death & Disease] Researchers investigated the roles of IGF-1 signaling during agonist-induced cardiac fibrosis and evaluated the molecular mechanisms in cultured cardiac fibroblasts. They found severe interstitial fibrosis in angiotensin II/phenylephrine infused myofibroblast-specific IGF-1R knockout mice compared to the wild-type mice.

[Seminars in Cell & Developmental Biology] Over the last decade, remarkable progresses have been made on cardiac reprogramming, particularly focusing on how to enhance conversion of fibroblasts to induced cardiomyocyte-like cells in vitro. The author discusses progresses and challenges of cardiac reprogramming in the translational context.

[Nature] Scientists used single-cell epigenomic analysis of hearts dynamically exposed to bromodomain and extra-terminal domain inhibitors to reveal a reversible transcriptional switch that underlied the activation of fibroblasts.

[Scientific Reports] Scientists identified cell–cell and cell-ECM interactions in the microenvironment of the early four-chambered vertebrate heart that drive cardiomyocyte organization and alignment.

[American Journal of Physiology-Heart and Circulatory Physiology] Investigators suggested that transthyretin deposited in tissue extracellular matrix may affect both the structure, function and gene expression of cardiac fibroblasts.