cardiomyocytes

[Cell Reports] Researchers characterized stage-specific methylation dynamics and the function of Ten-eleven translocations (TETs) during human cardiomyocyte differentiation. Human ESCs in which all three TET genes were inactivated failed to generate cardiomyocytes, with altered mesoderm patterning and defective cardiac progenitor specification.

[Biomedical Journal] Scientists probed into the role and the underlying regulatory mechanism of apoptosis-inducing factor mitochondria associated 1 (AIFM1) in myocardial injury.

[Journal of Cardiovascular Translational Research] Understanding the molecular mechanisms that regulate cardiomyocyte apoptosis is of great significance for the prevention and treatment of cardiovascular diseases.

[Cell Stem Cell] The authors described a human multilineage iPSC-derived organoid that recapitulated cooperative cardiac and gut development and maturation, with extensive cellular and structural complexity in both tissues.

[Acta Pharmacologica Sinica] In vitro, scientists found that DAPA inhibited the expression of cleaved caspase 3, Bax, C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the cardiomyoprotective protein Bcl-2 in angiotensin II (Ang II)-treated cardiomyocytes.

[Journal of Clinical Investigation] Scientists showed that rescue of pyrimidine biosynthesis by administration of uridine or by genetic targeting of ENPP1/AMP pathway enhanced repair after cardiac injury.