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cardiomyocytes

The Histone Demthylase KDM3A Protects the Myocardium from Ischemia/Reperfusion Injury via Promotion of ETS1 Expression

[Communications Biology] Researchers showed that KDM3A was significantly downregulated in rat ischemia/reperfusion and cellular hypoxia/reoxygenation models. KDM3A knockout exacerbated cardiac dysfunction and cardiomyocytes injury both in vivo and in vitro.

Bioactivity and miRNome Profiling of Native Extracellular Vesicles in Human Induced Pluripotent Stem Cell-Cardiomyocyte Differentiation

[Advanced Science] Scientists isolated extracellular vesicles (EVs) from key stages of the human induced pluripotent stem cell-cardiomyocyte differentiation and maturation, with the aim of identifying a promising cell biofactory for EV production, and pinpointed the genetic signatures of bioactive EVs.

LCZ696 Ameliorates Doxorubicin-Induced Cardiomyocyte Toxicity in Rats

[Scientific Reports] The authors investigated the potential benefit of LCZ696, an angiotensin receptor–neprilysin inhibitor against doxorubicin-induced cardiotoxicity in rats and H9c2 cells and determined whether the mechanism underlying any such effects involved its antioxidant activity.

PPARdelta Activation Induces Metabolic and Contractile Maturation of Human Pluripotent Stem-Cell-Derived Cardiomyocytes

[Cell Stem Cell] Researchers induced efficient human pluripotent stem-cell-derived cardiomyocytes maturation through metabolic-pathway modulations and found that peroxisome-proliferator-associated receptor (PPAR) signaling regulated glycolysis and fatty acid oxidation in an isoform-specific manner.

Tamoxifen Treatment Ameliorates Contractile Dysfunction of Duchenne Muscular Dystrophy Stem Cell-Derived Cardiomyocytes on Bioengineered Substrates

[NPJ Regenerative Medicine] To examine the effects of chronic 4-hydroxytamoxifen treatment, researchers used state-of-the-art human-induced pluripotent stem cell-derived cardiomyocytes and a bioengineered platform to model duchenne muscular dystrophy.

Whole Genome Sequencing Delineates Regulatory, Copy Number, and Cryptic Splice Variants in Early Onset Cardiomyopathy

[NPJ Genomic Medicine] Scientists analyzed whole-genome sequencing data in a discovery cohort of 209 pediatric cardiomyopathy patients and 1953 independent replication genomes and exomes and searched for protein-coding variants and non-coding variants predicted to affect the function or expression of genes.

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