cardiomyocytes

[Cell Systems] The authors developed a quantitative, imaging-based platform for the systematic and automated classification of subcellular organization in >30,000 individual human induced pluripotent stem cell-derived cardiomyocytes.

[npj Aging and Mechanisms of Disease] Researchers showed that the transverse tubular system (t-system) and proteins underlying excitation-contraction coupling in cardiomyocytes are characteristically remodeled with age, characterized by t-system alterations and sarcolemmal dissociation of ryanodine receptor clusters.

[Laboratory Investigation] The authors investigated the role of lncRNA X-inactive specific transcript (XIST) in septic myocardial injury and explored its mechanism.

[Cell Death & Disease] The effects of long non-coding RNA H19 (H19) on metabolic disorders, mitochondrial respiratory function, and mitophagy were investigated. Researchers suggested that DNA methylation-mediated downregulation of H19 expression played a crucial role in cardiomyocyte metabolic disorders.

[Circulation Research] The authors review the immune response to heart injury, its contribution to cardiac fibrosis, and the potential of immune modifying therapies to affect cardiac repair.

[Nature Communications] Scientists established a differentiation strategy that promotes the specification, proliferation and maturation of compact ventricular cardiomyocytes from human PSCs.