The authors showed that independently of GSDMD-mediated plasma membrane permeabilization, inflammasome receptors engaged caspase-1 and caspase-8, both of which redundantly promoted activation of apoptotic executioner caspase-3 and caspase-7 in pyroptotic macrophages.
Vasconcelos, N. M. de, Opdenbosch, N. V., Gorp, H. V., Martín-Pérez, R., Zecchin, A., Vandenabeele, P., & Lamkanfi, M. (2020). An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages. Cell Reports, 32(4). https://doi.org/10.1016/j.celrep.2020.107959Cite
Although both caspase-1 and caspase-11 could cleave gasdermin D in macrophages and neutrophils, researchers found that NLRC4-activated caspase-1 triggered pyroptosis in macrophages, but this pathway did not trigger pyroptosis in neutrophils.
Kovacs, S. B., Oh, C., Maltez, V. I., McGlaughon, B. D., Verma, A., Miao, E. A., & Aachoui, Y. (2020). Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. Cell Reports, 32(4). https://doi.org/10.1016/j.celrep.2020.107967Cite