Downregulation of Phosphoglycerate Mutase 5 Improves Microglial Inflammasome Activation after Traumatic Brain Injury

Researchers evaluated the effects of Pgam5 on neurological deficits and neuroinflammation of controlled cortical impact-induced TBI mouse model in vivo and LPS+ ATP-induced microglia model in vitro.
[Cell Death Discovery]
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Leukemic Progenitor Cells Enable Immunosuppression and Post-Chemotherapy Relapse via IL-36–Inflammatory Monocyte Axis

Researchers showed that abnormal IL-36 production activated by NF-κB was an essential feature of mouse and human leukemic progenitor cells.
[Science Advances]
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Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo

As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.
[Evidence-Based Complementary and Alternative Medicine]
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Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension

In human endothelial cells, a striking correlation was observed between the degree of endothelial cell activation as reflected by intracellular adhesion molecule 1, isoLG-adduct accumulation and intracellular GAS6 levels.
[Circulation Research]
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Human Umbilical Cord Mesenchymal Stem Cells Deliver Exogenous miR-26a-5p via Exosomes to Inhibit Nucleus Pulposus Cell Pyroptosis through METTL14/NLRP3

The human umbilical cord MSC exosomes were found to effectively improve the viability of nucleus pulposus cells and protect them from pyroptosis through targeting METTL14, with a methyltransferase catalyzing m6A modification.
[Molecular Medicine]
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SARS-CoV-2 N Protein Promotes NLRP3 Inflammasome Activation to Induce Hyperinflammation

Scientists showed a distinct mechanism by which SARS-CoV-2 N protein promoted NLRP3 inflammasome activation to induce hyperinflammation.
[Nature Communications]
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SARS-CoV-2 Nucleocapsid Suppresses Host Pyroptosis by Blocking Gasdermin D Cleavage

Investigators showed that the nucleocapsid of SARS-CoV-2 inhibited host pyroptosis by blocking Gasdermin D cleavage. SARS-CoV-2-infected monocytes showed enhanced cellular interleukin 1b (IL-1b) expression, but reduced IL-1b secretion.
[EMBO Journal]
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Extracellular NLRP3 Inflammasome Particles Are Internalized by Human Coronary Artery Smooth Muscle Cells and Induce Pro-Atherogenic Effects

Fluorescently labeled NLRP3 inflammasome particles were isolated from a mutant NLRP3-YFP cell line and used to treat primary human coronary artery smooth muscle cells for 4 and 24 hours.
[Scientific Reports]
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Pelargonic Acid Vanillylamide and Rosuvastatin Protect against Oxidized Low-Density Lipoprotein-Induced Endothelial Dysfunction by Inhibiting the NF-κB/NLRP3 Pathway and Improving Cell-Cell Junctions

Researchers investigated the synergistic effects of pelargonic acid vanillylamide and rosuvastatin on ox-LDL-induced inflammatory responses in human vascular endothelial cells.
[Chemico-Biological Interactions]
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The Role of the Mitochondrial Protein VDAC1 in Inflammatory Bowel Disease: A Potential Therapeutic Target

VBIT-12 treatment of cultured colon cells inhibited the DSS-induced VDAC1 overexpression, oligomerization, and apoptosis.
[Molecular Therapy]
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Microglial Signaling Pathway Deficits Associated with the Patient Derived R47H TREM2 Variants Linked to AD Indicate Inability to Activate Inflammasome

Apoptotic cell phagocytosis and soluble TREM2 shedding were unaltered, suggesting a disjoint between the pathways and the signaling cascades downstream of triggering receptor on myeloid cells 2 (TREM2) in R47H-expressing induced pluripotent stem cell-derived microglia (iPS-Mg), whilst metabolic deficits in glycolytic capacity and maximum respiration were reversed when R47H expressing iPS-Mg were exposed to phosphatidylserine+ expressing cells.
[Scientific Reports]
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