caspase-1

[Free Radical Biology and Medicine] Scientists investigated the important role and mechanism of C3a in preventing the occurrence of pyroptosis to protect the lung endothelial cells in sepsis-induced acute lung injury.

[Cell Death Discovery] Researchers investigated the role of histone deacetylase 11 (HDAC11) in vascular endothelial cell pyroptosis and its molecular mechanism.

[Hypertension Research] The authors investigated the mechanism of long noncoding RNAs Rian in myocardial ischemia–reperfusion injury-induced cardiomyocyte pyroptosis.

[Scientific Reports] The authors explored the anti-inflammatory effects and underlying molecular mechanism of povidone-iodine (PVP-I) on lipopolysaccharide-stimulated airway epithelial cells and investigated whether nasal instillation of PVP-I could suppress mucosal inflammation in non-eosinophilic chronic rhinosinusitis mice.

[Journal of Leukocyte Biology] Researchers hypothesized that cystic fibrosis airway neutrophils contributed to chronic inflammation, in part, via the packaging of inflammasome-inducing signals in extracellular vesicles.

[Evidence-Based Complementary and Alternative Medicine] Human coronary artery endothelial cells were induced with oxidized low-density lipoprotein to obtain cellular atherosclerosis models.