Scutellarin Ameliorates Pulmonary Fibrosis through Inhibiting NF-κB/NLRP3-Mediated Epithelial–Mesenchymal Transition and Inflammation

Investigators discovered that scutellarin suppressed inflammation and epithelial–mesenchymal transition in BLM-induced pulmonary fibrosis through NF-κB/NLRP3 signaling.
[Cell Death & Disease]
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation | Cell Death & Disease. (n.d.). Retrieved November 19, 2020, from https://www.nature.com/articles/s41419-020-03178-2 Cite
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PCSK9 Regulates Pyroptosis via mtDNA Damage in Chronic Myocardial Ischemia

This study was designed to test the hypothesis that proprotein convertase subtilisin/Kexin type 9 (PCSK9) regulates pyroptosis in cardiomyocytes during chronic myocardial ischemia. Primary cardiomyocytes were isolated from WT and PCSK9−/− mice.
[Basic Research in Cardiology]
Wang, X., Li, X., Liu, S., Brickell, A. N., Zhang, J., Wu, Z., Zhou, S., & Ding, Z. (2020). PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia. Basic Research in Cardiology, 115(6), 66. https://doi.org/10.1007/s00395-020-00832-w Cite
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Influenza A Viruses Limit NLRP3-NEK7-Complex Formation and Pyroptosis in Human Macrophages

Researchers demonstrated here that a small accessory protein of contemporary H5N1 and H3N2 influenza A viruses curtails fulminant cell death of infected human macrophages.
[EMBO Reports]
Boal-Carvalho, I., Mazel-Sanchez, B., Silva, F., Garnier, L., Yildiz, S., Bonifacio, J. P., Niu, C., Williams, N., Francois, P., Schwerk, N., Schöning, J., Carlens, J., Viemann, D., Hugues, S., & Schmolke, M. (2020). Influenza A viruses limit NLRP3-NEK7-complex formation and pyroptosis in human macrophages. EMBO Reports, n/a(n/a), e50421. https://doi.org/10.15252/embr.202050421 Cite
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Membrane Nanotubes Facilitate the Propagation of Inflammatory Injury in the Heart upon Overactivation of the β-Adrenergic Receptor

β-adrenergic receptor (β-AR) overactivation induced inflammasome activation in both the cardiomyocytes and cardiac fibroblasts of mice hearts following a subcutaneous injection of isoproterenol, a selective agonist of β-AR.
[Cell Death & Disease]
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The Novel Interplay between CD44 Standard Isoform and the Caspase-1/IL1B Pathway to Induce Hepatocellular Carcinoma Progression

Scientists observed that cluster differentiation 44 standard isoform (CD44s) was responsible for caspase-1/IL1B activation both in hepatocellular carcinoma (HCC) tissues and five HCC cell lines. In normoxia conditions, CD44s knockdown repressed the activation of caspase-1/IL1B via stimulating AMPK-mediated autophagy.
[Cell Death & Disease]
Li, J., Zhang, Y., Ruan, R., He, W., & Qian, Y. (2020). The novel interplay between CD44 standard isoform and the caspase-1/IL1B pathway to induce hepatocellular carcinoma progression. Cell Death & Disease, 11(11), 1–13. https://doi.org/10.1038/s41419-020-03158-6 Cite
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Cysteinyl Leukotriene D4 (LTD4) Promotes Airway Epithelial Cell Inflammation and Remodeling

Using primary human small airway epithelial cells researchers investigated the mechanism of leukotriene D4-induced inflammation and remodeling and assessed high proneness of obese mice to develop asthma upon challenge with allergen ovalbumin.
[Inflammation Research]
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BAFF-Driven NLRP3 Inflammasome Activation in B Cell

Scientists report BAFF engagement to BAFF receptor elicited both priming and activating signals for NLRP3 inflammasomes in primary B cells and B lymphoma cell lines.
[Cell Death & Disease]
Lim, K.-H., Chen, L.-C., Hsu, K., Chang, C.-C., Chang, C.-Y., Kao, C.-W., Chang, Y.-F., Chang, M.-C., & Chen, C. G. (2020). BAFF-driven NLRP3 inflammasome activation in B cells. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-03035-2 Cite
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HDAC6 Mediates an Aggresome-Like Mechanism for NLRP3 and Pyrin Inflammasome Activation

Scientists visualized inflammasome assembly by cellular imaging complemented by pharmacological inhibition and targeted deletion in cells and in mice.
[Science]
Magupalli, V. G., Negro, R., Tian, Y., Hauenstein, A. V., Caprio, G. D., Skillern, W., Deng, Q., Orning, P., Alam, H. B., Maliga, Z., Sharif, H., Hu, J. J., Evavold, C. L., Kagan, J. C., Schmidt, F. I., Fitzgerald, K. A., Kirchhausen, T., Li, Y., & Wu, H. (2020). HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science, 369(6510). https://doi.org/10.1126/science.aas8995 Cite
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NLRP3 Inflammasome in Endothelial Dysfunction

The authors provide a comprehensive perspective on the pivotal role of NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome activation in aggravating oxidative stress and endothelial dysfunction and the possible underlying mechanisms.
[Cell Death & Disease]
Bai, B., Yang, Y., Wang, Q., Li, M., Tian, C., Liu, Y., Aung, L. H. H., Li, P., Yu, T., & Chu, X. (2020). NLRP3 inflammasome in endothelial dysfunction. Cell Death & Disease, 11(9), 1–18. https://doi.org/10.1038/s41419-020-02985-x Cite
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The Inhibitor Effect of RKIP on Inflammasome Activation and Inflammasome-Dependent Diseases

The authors showed that Raf kinase inhibitor protein negatively regulated the activation of the NLRP1, NLRP3, and NLRC4 inflammasomes.
[Cellular & Molecular Immunology]
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hADSCs Derived Extracellular Vesicles Inhibit NLRP3inflammasome Activation and Dry Eye

Investigators addressed the therapeutic efficacy of human adipose tissue stem cells derived extracellular vesicles in a mouse model of dry eye disease and to investigate the underlying mechanisms involved.
[Scientific Reports]
Yu, C., Chen, P., Xu, J., Liu, Y., Li, H., Wang, L., & Di, G. (2020). hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye. Scientific Reports, 10(1), 14521. https://doi.org/10.1038/s41598-020-71337-8 Cite
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