caspase-1

[Molecular Medicine] The human umbilical cord MSC exosomes were found to effectively improve the viability of nucleus pulposus cells and protect them from pyroptosis through targeting METTL14, with a methyltransferase catalyzing m6A modification.

[Nature Communications] Scientists showed a distinct mechanism by which SARS-CoV-2 N protein promoted NLRP3 inflammasome activation to induce hyperinflammation.

[EMBO Journal] Investigators showed that the nucleocapsid of SARS-CoV-2 inhibited host pyroptosis by blocking Gasdermin D cleavage. SARS-CoV-2-infected monocytes showed enhanced cellular interleukin 1b (IL-1b) expression, but reduced IL-1b secretion.

[Scientific Reports] Fluorescently labeled NLRP3 inflammasome particles were isolated from a mutant NLRP3-YFP cell line and used to treat primary human coronary artery smooth muscle cells for 4 and 24 hours.

[Chemico-Biological Interactions] Researchers investigated the synergistic effects of pelargonic acid vanillylamide and rosuvastatin on ox-LDL-induced inflammatory responses in human vascular endothelial cells.

[Molecular Therapy] VBIT-12 treatment of cultured colon cells inhibited the DSS-induced VDAC1 overexpression, oligomerization, and apoptosis.