PB01 Suppresses Radio-Resistance by Regulating ATR Signaling in Human Non-Small-Cell Lung Cancer Cells

Scientists reported the antitumor effects and mechanism of a novel benzothiazole derivative 4-methoxy-cyclohexane carboxylic acid [2-(3,5-dimethyl-isoxazole-4-yl) sulpanil-benzothiazole-6-yl]-amide (PB01) in radiation-resistant human non-small-cell lung cancer cells.
[Scientific Reports]
Kim, T. W., Hong, D.-W., & Hong, S. H. (2021). PB01 suppresses radio-resistance by regulating ATR signaling in human non-small-cell lung cancer cells. Scientific Reports, 11(1), 12093. https://doi.org/10.1038/s41598-021-91716-z Cite
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Hyperbaric Oxygen Suppressed Tumor Progression through the Improvement of Tumor Hypoxia and Induction of Tumor Apoptosis in A549-Cell-Transferred Lung Cancer

Reserachers investigated the effects of hyperbaric oxygen treatment (HBOT) on solid tumors, such as lung cancer. Non-small cell human lung carcinoma A549-cell-transferred severe combined immunodeficiency mice were selected as an in vivo model to detect the potential mechanism of HBOT in lung tumors.
[Scientific Reports]
Chen, S.-Y., Tsuneyama, K., Yen, M.-H., Lee, J.-T., Chen, J.-L., & Huang, S.-M. (2021). Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancer. Scientific Reports, 11(1), 12033. https://doi.org/10.1038/s41598-021-91454-2 Cite
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Tissue Microarray Profiling and Integrative Proteomics Indicate the Modulatory Potential of Maytenus royleanus in Inhibition of Overexpressed TPD52 in Prostate Cancers

Scientists explored the mechanism of action of Maytenus royleanus (MEM) in prostate cancer (PCa) by employing an in vitro global proteome approach to get useful information of various signaling pathways and effected genes to define the mechanism of MEM action in Pca.
[Scientific Reports]
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Induction of T Helper 17 Cell Response by Interleukin-7 in Patients with Primary Cutaneous Melanoma

The aim of this study was to assess the effect of Interleukin-7 signaling on T helper 17 responses in patients with primary cutaneous melanoma.
[Melanoma Research]
He, H., Qiao, B., Guo, S., Cui, H., Li, N., Liu, H., Qin, J., He, J., Yang, X., Xue, W., & Wang, Y. (2021). Induction of T helper 17 cell response by interleukin-7 in patients with primary cutaneous melanoma. Melanoma Research, Publish Ahead of Print. https://doi.org/10.1097/CMR.0000000000000751 Cite
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Short Lifespan of Syngeneic Transplanted MSC Is a Consequence of In Vivo Apoptosis and Immune Cell Recruitment in Mice

Researchers investigated the survival and migration of MSC transplanted by various routes in order to identify the best delivery approach that provided an accumulation of therapeutic cells to the injured pancreas in the non-obese diabetic mouse.
[Cell Death & Disease]
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Preparation of Catechin Nanoemulsion from Oolong Tea Leaf Waste and Its Inhibition of Prostate Cancer Cells DU-145 and Tumors in Mice

Anti-cancer activity of catechin nanoemulsions prepared from Oolong tea leaf waste was studied on prostate cancer cells DU-145 and DU-145-induced tumors in mice.
[Molecules]
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Elevated GIGYF2 Expression Suppresses Tumor Migration and Enhances Sensitivity to Temozolomide in Malignant Glioma

Investigators found that elevation of GIGYF2 expression impaired cell migration and enhanced temozolomide sensitivity of human glioma cells.
[Cancer Gene Therapy]
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In Vitro Assessment of a Synergistic Combination of Gemcitabine and Zebularine in Pancreatic Cancer Cells

Reserachers investigated the effect of a cytidine deaminase inhibitor – Zebularine (Zeb) on anticancer activity of Gem in pancreatic cancer cell lines MiaPaCa-2, BxPC-3, and Panc-1. Zeb treatment synergistically increased Gem-induced cytotoxicity in all three pancreatic cancer cell lines.
[Experimental Cell Research]
In vitro assessment of a synergistic combination of Gemcitabine and Zebularine in pancreatic cancer cells. (2021). Experimental Cell Research, 112660. https://doi.org/10.1016/j.yexcr.2021.112660 Cite
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Antrodia salmonea Induces Apoptosis and Enhances Cytoprotective Autophagy in Colon Cancer Cells

Scientists explored the anti-cancer activity of Antrodia salmonea (AS) in colon cancer cells.MTT assay revealed that AS showed a remarkable effect on cell viability in colon cancer cells
[Aging-Us]
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Modulation of the Immune Microenvironment of High-Risk Ductal Carcinoma In Situ by Intralesional Pembrolizumab Injection

Patients with high-risk DCIS were enrolled in this 3×3 Phase I dose-escalation pilot study of two, four and eight mg intralesional injections of the PD-1 immune checkpoint inhibitor, pembrolizumab.
[npj Breast Cancer]
Glencer, A. C., Wong, J. M., Hylton, N. M., Krings, G., McCune, E., Rothschild, H. T., Loveday, T. A., Alvarado, M. D., Esserman, L. J., & Campbell, M. J. (2021). Modulation of the immune microenvironment of high-risk ductal carcinoma in situ by intralesional pembrolizumab injection. Npj Breast Cancer, 7(1), 1–10. https://doi.org/10.1038/s41523-021-00267-z Cite
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(-)-Epicatechin Acts as a Potent Agonist of the Membrane Androgen Receptor, ZIP9 (SLC39A9), to Promote Apoptosis of Breast and Prostate Cancer Cells

The authors investigated the potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in human breast and prostate cancer cells.
[Journal of Steroid Biochemistry and Molecular Biology]
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