Tag Archives: caspase-3

Enhancer of Zeste Homolog 2-Mediated Paired Box 8 Methylation Promotes Gastrointestinal Stromal Tumor Progression through Wnt4 Downregulation

The authors explored whether enhancer of zeste homolog 2-mediated paired box 8 methylation affects gastrointestinal stromal tumor (GIST) development through regulation of Wnt4. A total of 50 cases of GIST tissues were collected and the human GIST cell lines were cultured.
[Cancer Gene Therapy]
Miao, Z., Wu, F., Wei, H., Luo, Z., Wu, K., & Zhang, J. (2021). Enhancer of zeste homolog 2-mediated paired box 8 methylation promotes gastrointestinal stromal tumor progression through Wnt4 downregulation. Cancer Gene Therapy, 1–13. https://doi.org/10.1038/s41417-020-00266-5 Cite
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Isolation and Purification of Glycoglycerolipids To Induce Apoptosis in Breast Cancer Cells

Researchers investigated the therapeutic efficacy of cyanobacteria derived monogalactosyldiacylglycerol to inhibit breast cancer cell growth.
[Scientific Reports]
Abedin, M. R., & Barua, S. (2021). Isolation and purification of glycoglycerolipids to induce apoptosis in breast cancer cells. Scientific Reports, 11(1), 1298. https://doi.org/10.1038/s41598-020-80484-x Cite
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CCAAT/Enhancer-Binding Protein Delta Mediates Glioma Stem-Like Cell Enrichment and ATP-Binding Cassette Transporter ABCA1 Activation for Temozolomide Resistance in Glioblastoma

Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.
[Cell Death Discovery]
Wang, S.-M., Lin, W.-C., Lin, H.-Y., Chen, Y.-L., Ko, C.-Y., & Wang, J.-M. (2021). CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma. Cell Death Discovery, 7(1), 1–11. https://doi.org/10.1038/s41420-020-00399-4 Cite
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Cyclophilin A Inhibits A549 Cell Oxidative Stress and Apoptosis by Modulating the PI3K/Akt/mTOR Signaling Pathway

Researchers showed the protective effect of human recombinant CypA on hydrogen peroxide-induced oxidative damage in A549 cells, which play crucial roles in lung cancer.
[Bioscience Reports]
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Cardiac Telocytes Inhibit Cardiac Microvascular Endothelial Cell Apoptosis through Exosomal miRNA-21-5p-Targeted cdip1 Silencing to Improve Angiogenesis following Myocardial Infarction

Investigators showed that cardiac telocytes (CTs) inhibited cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cell death inducing p53 target 1 silencing to improve angiogenesis in myocardial infarction.
[Theranostics]
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Thermal Processing Has No Impact on Chemopreventive Effects of Oat and Barley Kernels in LT97 Colon Adenoma Cells

Growth inhibition, apoptosis, DNA integrity and gene expression of catalase were analyzed in LT97 colon adenoma cells. Concentrations of short-chain fatty acids, particularly butyrate, were higher in oat/barley FS, while ammonia levels were significantly lower than in the fermentation control.
[Nutrition and Cancer-An International Journal]
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SGLT1 Knockdown Prevents Glucose Fluctuation-Induced Apoptosis of Cardiomyocytes through Attenuating Oxidative Stress and Mitochondrial Dysfunction

Researchers investigated the role of sodium‑glucose cotransporter 1 (SGLT1) in rat H9c2 cardiomyocytes subjected to glucose fluctuation and the underlying mechanisms. They indicated that SGLT1 knockdown was able to restore cell proliferation and suppress cytotoxicity induced by glucose fluctuation.
[Biochemistry and Cell Biology]
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Ameliorative Effects of Alginate Oligosaccharide on Tumor Necrosis Factor-α-Induced Intestinal Epithelial Cell Injury

The porcine small intestinal epithelial cell line IPEC-J2 was used to assess the ameliorative effects of alginate oligosaccharide on tumour necrosis factor-α-induced intestinal epithelial cell injury.
[International Immunopharmacology]
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In Silico and In Vitro Studies on the Anti-Cancer Activity of Andrographolide Targeting Survivin in Human Breast Cancer Stem Cells

Human CD24–/CD44+ breast cancer stem cells (BCSCs) were treated with andrographolide in vitro for 24 hours. The cytotoxic effect of andrographolide on BCSCs was compared to that on human mesenchymal stem cells.
[PLoS One]
Wanandi, S. I., Limanto, A., Yunita, E., Syahrani, R. A., Louisa, M., Wibowo, A. E., & Arumsari, S. (2020). In silico and in vitro studies on the anti-cancer activity of andrographolide targeting survivin in human breast cancer stem cells. PLOS ONE, 15(11), e0240020. https://doi.org/10.1371/journal.pone.0240020 Cite
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Glutathione S‑Transferase ω 1 Promotes the Proliferation, Migration and Invasion, and Inhibits the Apoptosis of Non‑Small Cell Lung Cancer Cells, via the JAK/STAT3 Signaling Pathway

Scientists investigated the role of glutathione S‑transferase ω 1 (GSTO1) in non‑small cell lung cancer and to determine the potential molecular mechanism. GSTO1 expression levels in A549 cells were knocked down using short hairpin RNA and GSTO1 overexpression in H2122 cells was achieved using cDNA constructs.
[Molecular Medicine Reports]
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DNA Damage Induced by KP372-1 Hyperactivates PARP1 and Enhances Lethality of Pancreatic Cancer Cells With PARP Inhibition

Scientists showed that KP372-1 sensitized NAD(P)H:quinone oxidoreductase 1-expressing pancreatic cancer cells and spared immortalized normal pancreatic duct cells, hTERT-HPNE.
[Scientific Reports]
Viera, T., & Patidar, P. L. (2020). DNA damage induced by KP372-1 hyperactivates PARP1 and enhances lethality of pancreatic cancer cells with PARP inhibition. Scientific Reports, 10(1), 20210. https://doi.org/10.1038/s41598-020-76850-4 Cite
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