The authors explored whether enhancer of zeste homolog 2-mediated paired box 8 methylation affects gastrointestinal stromal tumor (GIST) development through regulation of Wnt4. A total of 50 cases of GIST tissues were collected and the human GIST cell lines were cultured.
[Cancer Gene Therapy]
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Researchers investigated the therapeutic efficacy of cyanobacteria derived monogalactosyldiacylglycerol to inhibit breast cancer cell growth.
Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.
[Cell Death Discovery]
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Wang, S.-M., Lin, W.-C., Lin, H.-Y., Chen, Y.-L., Ko, C.-Y., & Wang, J.-M. (2021). CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma. Cell Death Discovery, 7(1), 1–11. https://doi.org/10.1038/s41420-020-00399-4 Cite
Researchers showed the protective effect of human recombinant CypA on hydrogen peroxide-induced oxidative damage in A549 cells, which play crucial roles in lung cancer.
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Investigators showed that cardiac telocytes (CTs) inhibited cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cell death inducing p53 target 1 silencing to improve angiogenesis in myocardial infarction.
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Growth inhibition, apoptosis, DNA integrity and gene expression of catalase were analyzed in LT97 colon adenoma cells. Concentrations of short-chain fatty acids, particularly butyrate, were higher in oat/barley FS, while ammonia levels were significantly lower than in the fermentation control.
[Nutrition and Cancer-An International Journal]
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Researchers investigated the role of sodium‑glucose cotransporter 1 (SGLT1) in rat H9c2 cardiomyocytes subjected to glucose fluctuation and the underlying mechanisms. They indicated that SGLT1 knockdown was able to restore cell proliferation and suppress cytotoxicity induced by glucose fluctuation.
[Biochemistry and Cell Biology]
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The porcine small intestinal epithelial cell line IPEC-J2 was used to assess the ameliorative effects of alginate oligosaccharide on tumour necrosis factor-α-induced intestinal epithelial cell injury.
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Human CD24–/CD44+ breast cancer stem cells (BCSCs) were treated with andrographolide in vitro for 24 hours. The cytotoxic effect of andrographolide on BCSCs was compared to that on human mesenchymal stem cells.
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Wanandi, S. I., Limanto, A., Yunita, E., Syahrani, R. A., Louisa, M., Wibowo, A. E., & Arumsari, S. (2020). In silico and in vitro studies on the anti-cancer activity of andrographolide targeting survivin in human breast cancer stem cells. PLOS ONE, 15(11), e0240020. https://doi.org/10.1371/journal.pone.0240020 Cite
Scientists investigated the role of glutathione S‑transferase ω 1 (GSTO1) in non‑small cell lung cancer and to determine the potential molecular mechanism. GSTO1 expression levels in A549 cells were knocked down using short hairpin RNA and GSTO1 overexpression in H2122 cells was achieved using cDNA constructs.
[Molecular Medicine Reports]
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Scientists showed that KP372-1 sensitized NAD(P)H:quinone oxidoreductase 1-expressing pancreatic cancer cells and spared immortalized normal pancreatic duct cells, hTERT-HPNE.