Estrogen Alleviates Hepatocyte Necroptosis Depending on Gper in Hepatic Ischemia Reperfusion Injury

Researchers proved that estrogen had a protective effect on both hepatocyte hypoxia re-oxygen challenge and mouse hepatic ischemia reperfusion model.
[Journal of Physiology and Biochemistry]
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In Vitro Impact Preliminary Assessment of Airborne Particulate from Metalworking and Woodworking Industries

3D airway epithelial tissues allowed to mimic exposure conditions in vitro, generated human-relevant toxicology data, and allowed to elucidate the mode of action of pollutants.
[Scientific Reports]
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Tanshinone IIA Affects the Malignant Growth of Cholangiocarcinoma Cells by Inhibiting the PI3K-Akt-mTOR Pathway

The anti-cancer effects of Tanshinone IIA (Tan-IIA) were investigated by using subcutaneous tumorigenic model in nude mice and in the human cholangiocarcinoma cell lines in vitro. Tan-IIA treatment considerably suppressed the proliferation and migration of Cholangiocarcinoma cells while inducing apoptosis of Cholangiocarcinoma cells.
[Scientific Reports]
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Atractylenolide III Induces Apoptosis by Regulating the Bax/Bcl-2 Signaling Pathway in Human Colorectal Cancer HCT-116 Cells In Vitro and In Vivo

The results showed that atractylenolide III significantly inhibited the cell growth and induce cellular apoptosis in HCT-116 cells in a concentration dependence manner in vitro.
[Anti-Cancer Drugs]
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Gum Acacia PEG Iron Oxide Nanocomposite (GA-PEG-IONC) Induced Pharmacotherapeutic Activity on the Las R Gene Expression of Pseudomonas aeruginosa and HOXB13 Expression of Prostate Cancer (PC 3) Cell Line. A Green Therapeutic Approach of Molecular Mechanism Inhibition

Gum acacia – poly ethylene glycol grafted iron oxide nanocomposite was synthesised by in situ green science principles. The synthesized Nanocomposite was evaluated against the molecular mechanism of urinary tract pathogenic bacterial strains and prostate cancer cells.
[International Journal of Biological Macromolecules]
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Endotoxin Stabilizes Protein Arginine Methyltransferase 4 (PRMT4) Protein Triggering Death of Lung Epithelia

Scientists reported that a chromatin modulator protein arginine N-methyltransferase 4/coactivator-associated arginine methyltransferase 1 was elevated in human lung tissues with pneumonia and in experimental lung injury models.
[Cell Death & Disease]
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Diclofenac Down-Regulates COX-2 Induced Expression of CD44 and ICAM-1 in Human HT29 Colorectal Cancer Cells

Scientists investigated the effect of diclofenac, a selective COX-2 inhibitor, on cell adhesion molecules and apoptosis in human colon adenocarcinoma cells. Levels of homing cell adhesion molecule, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and epithelial cell adhesion molecule were evaluated in cancer cells overexpressing or not expressing COX-2.
[Naunyn-Schmiedebergs Archives of Pharmacology]
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Effect of Warm Acupuncture Combined with Bone Marrow Mesenchymal Stem Cells Transplantation on Cartilage Tissue in Rabbit Knee Osteoarthritis

After warm acupuncture combined with bone-marrow MSCs, the Modified Lequesne MG knee joint assessment scale was used to evaluate the degree of knee joint behavior, the Taiping Peng method generally observed the histomorphology changes of knee osteoarthritis rabbit cartilage, and hematoxylin-eosin staining, safranin O green staining, and toluidine blue staining were conducted to evaluate the extent of cartilage tissue pathology.
[Evidence-Based Complementary and Alternative Medicine]
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A Mutation in Desmin Makes Skeletal Muscle Less Vulnerable to Acute Muscle Damage after Eccentric Loading in Rats

To investigate the role of R349P Des in mechanical loading, scientists stimulated the sciatic nerve of wild-type littermates and animals carrying the mutation causing a lengthening contraction of the dorsi flexor muscles.
[FASEB Journal]
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Combinatorial Antitumor Effects of Amino Acids and Epigenetic Modulations in Hepatocellular Carcinoma Cell Lines

HepG2 and Huh7 cells were treated with different concentrations of L-leucine, L-glutamine, or L-methionine and cell viability was determined using MTT assay. Insulin-like growth factor 1, phosphorylated ribosomal protein S6 kinase, p53, and cyclin D1 protein levels were assayed using ELISA.
[Naunyn-Schmiedebergs Archives of Pharmacology]
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Carbonic Anhydrase III Attenuates Hypoxia-Induced Apoptosis and Activates PI3K/Akt/mTOR Pathway in H9c2 Cardiomyocyte Cell Line

To investigate the role of CAIII in the apoptosis of myocytes under hypoxic conditions and facilitate the strategy for treating hypoxia-induced damage, in vitro experiments in H9c2 were employed.
[Cardiovascular Toxicology]
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