The authors found that tideglusib (TID) markedly reduced the cell viability of different osteosarcoma cell lines. Cell cycle arrest distributed in G2/M was markedly up-regulated in TID-incubated osteosarcoma cells through enhancing p21 expression levels.
[Biochemical and Biophysical Research Communications]
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Wei, D., Zhu, X., Li, S., Liu, G., Wang, Y., Wang, W., Zhang, Q., & Jiang, S. (2021). Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3β/NOTCH1 signaling. Biochemical and Biophysical Research Communications, 554, 206–213. https://doi.org/10.1016/j.bbrc.2020.12.055 Cite
Utidelone (UTD1) dramatically inhibited colorectal cancer cell proliferation in vitro. Immunofluorescence staining showed that UTD1 induced the formation of microtubule bundling and asters in RKO cells.
[Cell Death & Disease]
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Antibody–drug nanoparticles were engineered by synthesizing pure anti-cancer drug nanorods in the core of nanoparticles with a therapeutic monoclonal antibody, Trastuzumab on the surface of NRs for specific targeting and synergistic treatments of human epidermal growth factor receptor 2 positive breast cancer cells.
ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
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Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
Researchers determined whether recombinant Islet NeoGenesis Associated Protein (rINGAP) and its active core, a pentadecapeptide INGAP104–118, protected β cells against cytokine-induced death.
[Cell Death Discovery]
Homing of human umbilical cord-MSCs was detected by fluorescence microscopy and examination of immunostained sections for human CD105 and CD34 were performed.
[Annals of Anatomy-Anatomischer Anzeiger]
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El-naseery, N. I., Elewa, Y. H. A., Arafa, M. A. A., Sabbah, W. S., & Dessouky, A. A. (2021). Mesenchymal stem cells enhance AQP1 expression in the sublingual salivary gland of ovariectomized menopausal rat model. Annals of Anatomy - Anatomischer Anzeiger, 151714. https://doi.org/10.1016/j.aanat.2021.151714 Cite
Investigators examined the cytotoxic effects of colchicine on PC3 cells to elucidate their possible underlying mechanisms.
[Toxicology in Vitro]
Epidermal growth factor-like domain-containing protein 7 (EGFL7) was upregulated in several colorectal cancer cell lines as compared with normal intestinal epithelial cell line HIEC. Transfection of EGFL7 siRNA significantly decreased cell proliferation and invasion capacity of SW620 and LoVo cells.
[International Journal of Clinical Oncology]
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Using bone marrow transplantation and cell type-specific Casp3 knockout mice, scientists demonstrated that Casp3/GSDME-mediated pyroptosis in renal parenchymal cells, but not in hematopoietic cells, played predominant roles in this process.
[Cell Death & Differentiation]
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Li, Y., Yuan, Y., Huang, Z., Chen, H., Lan, R., Wang, Z., Lai, K., Chen, H., Chen, Z., Zou, Z., Ma, H., Lan, H.-Y., Mak, T. W., & Xu, Y. (2021). GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy. Cell Death & Differentiation, 1–18. https://doi.org/10.1038/s41418-021-00755-6 Cite
Lotus leaf flavonoids (LLF) were applied to human lung cancer A549 cells and human small cell lung cancer cells H446 in vitro to verify the effect of LLF on apoptosis in these cells through the ROS/p38 MAPK pathway.
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Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells through the ROS/p38 MAPK pathway | Biological Research | Full Text. (n.d.). Retrieved March 4, 2021, from https://biolres.biomedcentral.com/articles/10.1186/s40659-021-00330-w Cite
The relative expression of LINC00665, miR-4458 and DOCK1 in acute myeloid leukemia (AML) samples was measured using qRT-PCR, and the protein level of DOCK1 in AML cell lines was examined using western blot.
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