Scientists applied experimental allogeneic human neural cell therapy after injury in ex vivo spinal cord slices.
[Stem Cell Research & Therapy]
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Lin, C., Calzarossa, C., Fernandez-Zafra, T., Liu, J., Li, X., Ekblad-Nordberg, Å., Vazquez-Juarez, E., Codeluppi, S., Holmberg, L., Lindskog, M., Uhlén, P., & Åkesson, E. (2020). Human ex vivo spinal cord slice culture as a useful model of neural development, lesion, and allogeneic neural cell therapy. Stem Cell Research & Therapy, 11(1), 320. https://doi.org/10.1186/s13287-020-01771-y Cite
The authors suggested that Sp1 was required for p53-mediated transactivation of neuronal pro-apoptotic molecules and that mithramycin might have attenuated neuronal cell death in conditions predominantly involving DNA-damage-induced p53-dependent intrinsic apoptosis.
[Cell Death & Disease]
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The authors showed that independently of GSDMD-mediated plasma membrane permeabilization, inflammasome receptors engaged caspase-1 and caspase-8, both of which redundantly promoted activation of apoptotic executioner caspase-3 and caspase-7 in pyroptotic macrophages.
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Silencing Krüppel like factor 10 (Klf10) sensitized primary hepatocytes to apoptosis along with increased caspase 3 activation in response to TNFα.
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Functional inhibition of PKCλ through siRNA-mediated knockdown or CRISPR-Cas9-mediated knockout in ALDH1high MDA-MB 157 and MDA-MB 468 basal-like breast cancer cells led to increases in the numbers of trypan blue-positive and active-caspase 3-positive cells, as well as suppression of tumor-sphere formation and cell migration.
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