Scientists reported the antitumor effects and mechanism of a novel benzothiazole derivative 4-methoxy-cyclohexane carboxylic acid [2-(3,5-dimethyl-isoxazole-4-yl) sulpanil-benzothiazole-6-yl]-amide (PB01) in radiation-resistant human non-small-cell lung cancer cells.
Reserachers investigated the effects of hyperbaric oxygen treatment (HBOT) on solid tumors, such as lung cancer. Non-small cell human lung carcinoma A549-cell-transferred severe combined immunodeficiency mice were selected as an in vivo model to detect the potential mechanism of HBOT in lung tumors.
7753456 P8VVKPPM items 1 apa default asc 1
Chen, S.-Y., Tsuneyama, K., Yen, M.-H., Lee, J.-T., Chen, J.-L., & Huang, S.-M. (2021). Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancer. Scientific Reports, 11(1), 12033. https://doi.org/10.1038/s41598-021-91454-2 Cite
Scientists explored the mechanism of action of Maytenus royleanus (MEM) in prostate cancer (PCa) by employing an in vitro global proteome approach to get useful information of various signaling pathways and effected genes to define the mechanism of MEM action in Pca.
6445212 Z22YPUKE items 1 apa default asc 1
The aim of this study was to assess the effect of Interleukin-7 signaling on T helper 17 responses in patients with primary cutaneous melanoma.
7753456 YUS4AILM items 1 apa default asc 1
He, H., Qiao, B., Guo, S., Cui, H., Li, N., Liu, H., Qin, J., He, J., Yang, X., Xue, W., & Wang, Y. (2021). Induction of T helper 17 cell response by interleukin-7 in patients with primary cutaneous melanoma. Melanoma Research, Publish Ahead of Print. https://doi.org/10.1097/CMR.0000000000000751 Cite
Researchers investigated the survival and migration of MSC transplanted by various routes in order to identify the best delivery approach that provided an accumulation of therapeutic cells to the injured pancreas in the non-obese diabetic mouse.
[Cell Death & Disease]
6445212 WBR67JMF items 1 apa default asc 1
Anti-cancer activity of catechin nanoemulsions prepared from Oolong tea leaf waste was studied on prostate cancer cells DU-145 and DU-145-induced tumors in mice.
6445212 F9S24YKJ items 1 apa default asc 1
Investigators found that elevation of GIGYF2 expression impaired cell migration and enhanced temozolomide sensitivity of human glioma cells.
[Cancer Gene Therapy]
6445212 6LY9ITP2 items 1 apa default asc 1
Reserachers investigated the effect of a cytidine deaminase inhibitor – Zebularine (Zeb) on anticancer activity of Gem in pancreatic cancer cell lines MiaPaCa-2, BxPC-3, and Panc-1. Zeb treatment synergistically increased Gem-induced cytotoxicity in all three pancreatic cancer cell lines.
[Experimental Cell Research]
Scientists explored the anti-cancer activity of Antrodia salmonea (AS) in colon cancer cells.MTT assay revealed that AS showed a remarkable effect on cell viability in colon cancer cells
6445212 APTXM8VV items 1 apa default asc 1
Patients with high-risk DCIS were enrolled in this 3×3 Phase I dose-escalation pilot study of two, four and eight mg intralesional injections of the PD-1 immune checkpoint inhibitor, pembrolizumab.
[npj Breast Cancer]
6445212 LM4A8VZM items 1 apa default asc 1
Glencer, A. C., Wong, J. M., Hylton, N. M., Krings, G., McCune, E., Rothschild, H. T., Loveday, T. A., Alvarado, M. D., Esserman, L. J., & Campbell, M. J. (2021). Modulation of the immune microenvironment of high-risk ductal carcinoma in situ by intralesional pembrolizumab injection. Npj Breast Cancer, 7(1), 1–10. https://doi.org/10.1038/s41523-021-00267-z Cite
The authors investigated the potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in human breast and prostate cancer cells.
[Journal of Steroid Biochemistry and Molecular Biology]
6445212 ZG52YX9T items 1 apa default asc 1