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Superoxide Anion Radical Induced Phototoxicity of 2,4, 5,6-Tetraminopyrimidine Sulfate via Mitochondrial-Mediated Apoptosis in Human Skin Keratinocytes at Ambient UVR Exposure

[Food and Chemical Toxicology] Researchers studied the photosensitization potential and mechanism involved in dermal phototoxicity of 2,4,5,6-tetraaminopyrimidine sulfate exposed to the dark and UVA/UVB/Sunlight by using different in-chemico and mammalian HaCaT cells, as test systems.

Overexpression of Multiple Epidermal Growth Factor Like Domains 11 Rescues Anoikis Survival through Tumor Cells-Platelet Interaction in Triple Negative Breast Cancer Cells

[Life Sciences] The role of multiple epidermal growth factor like domains 11 (MEGF11) was studied in human TNBC MDA-MB-231 and MDA-MB-468 cells by overexpressing MEGF11 using non-attached culture.

MiR-222-3p Inhibits Formation of Medulloblastoma Stem-Like Cells by Targeting Notch2/C-myc Signaling Pathway

[Immunopharmacology and Immunotoxicology] Scientists investigated the effects of miR-222-3p on the formation of medulloblastoma stem-like cells via the Notch2/c-myc pathway.

Rhoifolin from Plumula Nelumbinis Exhibits Anti-cancer Effects in Pancreatic Cancer via AKT/JNK Signaling Pathways

[Scientific Reports] Cell viability assay revealed that apiin, rhoifolin, and vitexin could inhibit proliferation of PANC-1 and ASPC-1, with rhoifolin showing the maximum inhibitory effect.

Gymnemic Acid Protects Murine Pancreatic β-Cells by Moderating Hyperglycemic Stress-Induced Inflammation and Apoptosis in Type 1 Diabetic Rats

[Journal of Biochemical and Molecular Toxicology] Scientists delineated the role of gymnemic acid in protecting pancreatic β-cells in diabetic animals, with special reference to inflammation and apoptosis.

The Marine Factor 3,5-Dihydroxy-4-Methoxybenzyl Alcohol Suppresses Growth, Migration and Invasion and Stimulates Death of Metastatic Human Prostate Cancer Cells: Targeting Diverse Signaling Processes

[Anti-Cancer Drugs] Scientists investigated whether the novel factor 3,5-dihydroxy-4-methoxybenzyl alcohol, suppressed the activity of metastatic human prostate cancer PC-3 or DU-145 cells.