Tag Archives: caspase-3

Tideglusib Suppresses Stem-Cell-Like Features and Progression of Osteosarcoma by Inhibiting GSK-3β/NOTCH1 Signaling

The authors found that tideglusib (TID) markedly reduced the cell viability of different osteosarcoma cell lines. Cell cycle arrest distributed in G2/M was markedly up-regulated in TID-incubated osteosarcoma cells through enhancing p21 expression levels.
[Biochemical and Biophysical Research Communications]
Wei, D., Zhu, X., Li, S., Liu, G., Wang, Y., Wang, W., Zhang, Q., & Jiang, S. (2021). Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3β/NOTCH1 signaling. Biochemical and Biophysical Research Communications, 554, 206–213. https://doi.org/10.1016/j.bbrc.2020.12.055 Cite
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Utidelone Inhibits Growth of Colorectal Cancer Cells through ROS/JNK Signaling Pathway

Utidelone (UTD1) dramatically inhibited colorectal cancer cell proliferation in vitro. Immunofluorescence staining showed that UTD1 induced the formation of microtubule bundling and asters in RKO cells.
[Cell Death & Disease]
Li, F., Huang, T., Tang, Y., Li, Q., Wang, J., Cheng, X., Zhang, W., Zhang, B., Zhou, C., & Tu, S. (2021). Utidelone inhibits growth of colorectal cancer cells through ROS/JNK signaling pathway. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03619-6 Cite
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Antibody–Drug Nanoparticle Induces Synergistic Treatment Efficacies in HER2 Positive Breast Cancer Cells

Antibody–drug nanoparticles were engineered by synthesizing pure anti-cancer drug nanorods in the core of nanoparticles with a therapeutic monoclonal antibody, Trastuzumab on the surface of NRs for specific targeting and synergistic treatments of human epidermal growth factor receptor 2 positive breast cancer cells.
[Scientific Reports]
Abedin, M. R., Powers, K., Aiardo, R., Barua, D., & Barua, S. (2021). Antibody–drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells. Scientific Reports, 11(1), 7347. https://doi.org/10.1038/s41598-021-86762-6 Cite
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CircRNA RSF1 Regulated Ox-LDL Induced Vascular Endothelial Cells Proliferation, Apoptosis and Inflammation through Modulating miR-135b-5p/HDAC1 Axis in Atherosclerosis

ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
[Biological Research]
Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
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Islet Neogenesis Associated Protein (INGAP) Protects Pancreatic β Cells from IL-1β and IFNγ-Induced Apoptosis

Researchers determined whether recombinant Islet NeoGenesis Associated Protein (rINGAP) and its active core, a pentadecapeptide INGAP104–118, protected β cells against cytokine-induced death.
[Cell Death Discovery]
Nano, E., Petropavlovskaia, M., & Rosenberg, L. (2021). Islet neogenesis associated protein (INGAP) protects pancreatic β cells from IL-1β and IFNγ-induced apoptosis. Cell Death Discovery, 7(1), 1–15. https://doi.org/10.1038/s41420-021-00441-z Cite
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Mesenchymal Stem Cells Enhance AQP1 Expression in the Sublingual Salivary Gland of Ovariectomized Menopausal Rat Model

Homing of human umbilical cord-MSCs was detected by fluorescence microscopy and examination of immunostained sections for human CD105 and CD34 were performed.
[Annals of Anatomy-Anatomischer Anzeiger]
El-naseery, N. I., Elewa, Y. H. A., Arafa, M. A. A., Sabbah, W. S., & Dessouky, A. A. (2021). Mesenchymal stem cells enhance AQP1 expression in the sublingual salivary gland of ovariectomized menopausal rat model. Annals of Anatomy - Anatomischer Anzeiger, 151714. https://doi.org/10.1016/j.aanat.2021.151714 Cite
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Investigation of Molecular Mechanisms Underlying the Antiproliferative Effects of Colchicine against PC3 Prostate Cancer Cells

Investigators examined the cytotoxic effects of colchicine on PC3 cells to elucidate their possible underlying mechanisms.
[Toxicology in Vitro]
Ergul, M., & Bakar-Ates, F. (2021). Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicology in Vitro, 105138. https://doi.org/10.1016/j.tiv.2021.105138 Cite
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EGFL7 as a Novel Therapeutic Candidate Regulates Cell Invasion and Anoikis in Colorectal Cancer through PI3K/AKT Signaling Pathway

Epidermal growth factor-like domain-containing protein 7 (EGFL7) was upregulated in several colorectal cancer cell lines as compared with normal intestinal epithelial cell line HIEC. Transfection of EGFL7 siRNA significantly decreased cell proliferation and invasion capacity of SW620 and LoVo cells.
[International Journal of Clinical Oncology]
Juan, Z., Dake, C., Tanaka, K., & Shuixiang, H. (2021). EGFL7 as a novel therapeutic candidate regulates cell invasion and anoikis in colorectal cancer through PI3K/AKT signaling pathway. International Journal of Clinical Oncology. https://doi.org/10.1007/s10147-021-01888-x Cite
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GSDME-Mediated Pyroptosis Promotes Inflammation and Fibrosis in Obstructive Nephropathy

Using bone marrow transplantation and cell type-specific Casp3 knockout mice, scientists demonstrated that Casp3/GSDME-mediated pyroptosis in renal parenchymal cells, but not in hematopoietic cells, played predominant roles in this process.
[Cell Death & Differentiation]
Li, Y., Yuan, Y., Huang, Z., Chen, H., Lan, R., Wang, Z., Lai, K., Chen, H., Chen, Z., Zou, Z., Ma, H., Lan, H.-Y., Mak, T. W., & Xu, Y. (2021). GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy. Cell Death & Differentiation, 1–18. https://doi.org/10.1038/s41418-021-00755-6 Cite
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Lotus Leaf Flavonoids Induce Apoptosis of Human Lung Cancer A549 Cells through the ROS/p38 MAPK Pathway

Lotus leaf flavonoids (LLF) were applied to human lung cancer A549 cells and human small cell lung cancer cells H446 in vitro to verify the effect of LLF on apoptosis in these cells through the ROS/p38 MAPK pathway.
[Biological Research]
Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells through the ROS/p38 MAPK pathway | Biological Research | Full Text. (n.d.). Retrieved March 4, 2021, from https://biolres.biomedcentral.com/articles/10.1186/s40659-021-00330-w Cite
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LINC00665 Promotes the Progression of Acute Myeloid Leukemia by Regulating the miR-4458/DOCK1 Pathway

The relative expression of LINC00665, miR-4458 and DOCK1 in acute myeloid leukemia (AML) samples was measured using qRT-PCR, and the protein level of DOCK1 in AML cell lines was examined using western blot.
[Scientific Reports]
Yang, X., Wang, Y., Pang, S., Li, X., Wang, P., Ma, R., Ma, Y., & Song, C. (2021). LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway. Scientific Reports, 11(1), 5009. https://doi.org/10.1038/s41598-021-82834-9 Cite
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