Hydrostatic Pressure Can Induce Apoptosis of the Skin

Using a human dermal fibroblast cell line in suspension culture, investigators found that high hydrostatic pressure at 50 MPa for ≥ 36 h completely induced fibroblast cell death via apoptosis based on the morphological changes in transmission electron microscopy, reactive oxygen species elevation, caspase activation and phosphatidylserine membrane translocation.
[Scientific Reports]
Le, T. M., Morimoto, N., Ly, N. T. M., Mitsui, T., Notodihardjo, S. C., Munisso, M. C., Kakudo, N., Moriyama, H., Yamaoka, T., & Kusumoto, K. (2020). Hydrostatic pressure can induce apoptosis of the skin. Scientific Reports, 10(1), 17594. https://doi.org/10.1038/s41598-020-74695-5 Cite
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Restoring BMP4 Expression in Vascular Endothelial Progenitors Ameliorates Maternal Diabetes-Induced Apoptosis and Neural Tube Defects

The authors determined whether restoring diabetes-inhibited BMP4 expression in Flk-1+ progenitors effectively prevented maternal diabetes-induced embryonic vasculopathy and neural tube defects.
[Cell Death & Disease]
Cao, S., Reece, E. A., Shen, W.-B., & Yang, P. (2020). Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03078-5 Cite
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Shrimp Shells Extracted Chitin in Silver Nanoparticle Synthesis: Expanding Its Prophecy towards Anticancer Activity in Human Hepatocellular Carcinoma HepG2 Cells

The well-organized, simplistic, and biological route of AgNPs (AgNPs) was synthesized using shrimp shell extracted chitin as reducing, capping and stabilizing factor under the optimized conditions. The anticancer potential of synthesized biogenic AgNPs was evaluated against human hepatocarcinoma cells.
[International Journal of Biological Macromolecules]
Vijayakumar, M., Priya, K., Ilavenil, S., Janani, B., Vedarethinam, V., Ramesh, T., Arasu, M. V., Al-Dhabi, N. A., Kim, Y.-O., & Kim, H.-J. (2020). Shrimp shells extracted chitin in silver nanoparticle synthesis: Expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.10.032 Cite
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Engineered Cardiac Tissues: A Novel In Vitro Model to Investigate the Pathophysiology of Mouse Diabetic Cardiomyopathy

Researchers developed a murine-based engineered cardiac tissues (ECTs) model to investigate cardiac injury produced by advanced glycation end-products (AGEs). One findinf was that AGEs treatment significantly increased the markers of fibrosis (TGF-β, α-SMA, Ctgf, Collagen I-α1, Collagen III-α1, and Fn1) and hypertrophy.
[Acta Pharmacologica Sinica]
Wang, X., Chen, X., Yu, H., Tan, Y., Lin, Q., Keller, B. B., Zheng, Y., & Cai, L. (2020). Engineered cardiac tissues: a novel in vitro model to investigate the pathophysiology of mouse diabetic cardiomyopathy. Acta Pharmacologica Sinica, 1–10. https://doi.org/10.1038/s41401-020-00538-8 Cite
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Cdc6 Disruption Leads to Centrosome Abnormalities and Chromosome Instability in Pancreatic Cancer Cells

Cell division cycle 6 (Cdc6)-depleted pancreatic cancer cells significantly inhibited cell proliferation and colony formation, delayed G2/M cell cycle progression, and increased expression of p-histone H3 and cyclin A2 levels.
[Scientific Reports]
Youn, Y., Lee, J., Kim, J., Kim, J. H., & Hwang, J.-H. (2020). Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells. Scientific Reports, 10(1), 16518. https://doi.org/10.1038/s41598-020-73474-6 Cite
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Diltiazem Potentiates the Cytotoxicity of Gemcitabine and 5-Fluorouracil in PANC-1 Human Pancreatic Cancer Cells through Inhibition of P-Glycoprotein

The cytotoxic effect of diltiazem, gemcitabine, and 5-fluorouracil in single and combined forms against PANC-1 and AsPC-1 cells were assayed by MTT. Flow cytometric analysis was used for the determination of cell cycle, apoptosis, and stemness markers in pancreatic cancer cells.
[Life Sciences]
El-Mahdy, H. A., El-Husseiny, A. A., Kandil, Y. I., & Gamal El-Din, A. M. (2020). Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein. Life Sciences, 118518. https://doi.org/10.1016/j.lfs.2020.118518 Cite
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The Botanical Component p-Hydroxycinnamic Acid Suppresses the Growth and Bone Metastatic Activity of Human Prostate Cancer PC-3 Cells In Vitro

Scientists investigated the anticancer effects of botanical component p-hydroxycinnamic acid on the PC-3 cells in vitro model of bone metastatic human prostate cancer.
[Cancer Research]
Yamaguchi, M., Murata, T., & Ramos, J. W. (2020). The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-020-03405-5 Cite
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Overexpressed sFRP3 Exerts an Inhibitory Effect on Hepatocellular Carcinoma via Inactivation of the Wnt/β-Catenin Signaling Pathway

Researchers investigated the possible regulatory effects of a secreted frizzled-related protein (sFRP3) on the Wnt/β-catenin signaling pathway and their interactions in hepatocellular carcinoma occurrence.
[Cancer Gene Therapy]
Fang, L., Gao, C., Bai, R.-X., Wang, H.-F., & Du, S.-Y. (2020). Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway. Cancer Gene Therapy, 1–17. https://doi.org/10.1038/s41417-020-0201-z Cite
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Discovery of a Novel Dual-Target Inhibitor against RSK1 and MSK2 to Suppress Growth of Human Colon Cancer

The authors identified a novel dual-target inhibitor, APIO-EE-07, that could block both RSK1 and MSK2 kinase activity in a dose-dependent manner. APIO-EE-07 inhibited cell growth and induced apoptosis and also increased expression of Bax as well as cleaved caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downstream targets, including CREB and ATF1.
[Oncogene]
Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer | Oncogene. (n.d.). Retrieved September 24, 2020, from https://www.nature.com/articles/s41388-020-01467-w Cite
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CB11, a Novel Purine-Based PPARɣ Ligand, Overcomes Radio-Resistance by Regulating ATM Signaling and EMT in Human Non-Small-Cell Lung Cancer Cells

CB11 caused cell death via reactive oxygen species-mediated ATM-p53-GADD45α signaling in human non-small-cell lung cancer cells, and diphenyleneiodonium, an NADPH oxidase inhibitor, decreases cell death by inhibiting CB11-mediated ATM signaling.
[British Journal of Cancer]
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Extracellular Vesicle-Cargo miR-185-5p Reflects Type II Alveolar Cell Death after Oxidative Stress

Scientists found that hyperoxia and its derivative, reactive oxygen species, upregulated miR-185-5p, but not miR-185-3p, in alveolar cells.
[Cell Death Discovery]
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