Curcumin Suppresses Cell Proliferation and Triggers Apoptosis in Vemurafenib-Resistant Melanoma Cells by Downregulating the EGFR Signaling Pathway

Vemurafenib-resistant A375.S2 cells were established, and the functional mechanism of the epidermal growth factor receptor (EGFR), serine–threonine kinase, and the extracellular signal-regulated kinase signaling induced by curcumin was investigated in A375.S2/VR cells in vitro.
[Environmental Toxicology]
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Anemoside B4 Sensitizes Human Colorectal Cancer to Fluorouracil-Based Chemotherapy through Src-Mediated Cell Apoptosis

Scientists explored the efficacy of anemoside B4 (AB4) in 5-Fluorouracil (FU)-based chemotherapy in colorectal cancer cells and the underlying molecular mechanisms. They indicated a significant synergistic activity of AB4 in 5-FU treated colorectal cancer cells
[Aging]
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Maternal Selenium Deficiency Suppresses Proliferation, Induces Autophagy Dysfunction, Apoptosis in the Placenta of Mice

Researchers found that maternal selenium (Se) deficiency decreased placental Se concentration and expressions of some antioxidant selenoproteins.
[Metallomics]
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Atractylenolide III Induces Apoptosis by Regulating the Bax/Bcl-2 Signaling Pathway in Human Colorectal Cancer HCT-116 Cells In Vitro and In Vivo

The results showed that atractylenolide III significantly inhibited the cell growth and induce cellular apoptosis in HCT-116 cells in a concentration dependence manner in vitro.
[Anti-Cancer Drugs]
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The Petroleum Ether Extract of Brassica rapa L. Induces Apoptosis of Lung Adenocarcinoma Cells via the Mitochondria-Dependent Pathway

The effects and pharmacological mechanisms of BRPS on the treatment of lung cancer were investigated both in vitro and in vivo.
[Food & Function]
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Bellicum and MD Anderson Announce Additional License Agreement for Use of CaspaCIDe® Safety Switch

Bellicum Pharmaceuticals, Inc. and The University of Texas MD Anderson Cancer Center announced a global option and license agreement covering certain intellectual property and technology rights regarding Bellicum’s CaspaCIDe® safety switch and related technologies, and the use of rimiducid, an agent used to activate the safety switch.
[Bellicum Pharmaceuticals, Inc.]
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Dexamethasone Induces Pancreatic β-Cell Apoptosis through Upregulation of TRAIL Death Receptor

A mechanism of dexamethasone-induced pancreatic β-cell apoptosis through the TRAIL pathway was investigated in cultured cells and isolated mouse islets.
[Journal of Molecular Endocrinology]
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Tonkinensine B Induces Apoptosis through Mitochondrial Dysfunction and Inactivation of the PI3K/AKT Pathway in Triple-Negative Breast Cancer Cells

With the help of cell cytotoxicity, the effect of tonkinensine B on MDA-MB-231 cells was investigated. The levels of key apoptosis-associated proteins Bcl-2, Bax, caspase-9, caspase-3 and AKT in MDA-MB-231 cells were analysed to determine whether tonkinensine B caused apoptosis via the mitochondrial pathway.
[Journal of Pharmacy and Pharmacology]
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Dexamethasone Induces Pancreatic β-Cell Apoptosis through Upregulation of TRAIL Death Receptor

Researchers investigated the mechanism of dexamethasone-induced pancreatic β-cell apoptosis through the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway in cultured cells and isolated mouse islets.
[Journal of Molecular Endocrinology]
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Protective Role of ABCA1 in Ischemic Preconditioning Is Mediated by Downregulation of miR-33-5p and miR-135-5p

Expression levels of messenger RNAs and proteins were examined in the ipsilateral cortex, and mimics and inhibitors of selective miRNAs were transfected into Neuro-2a cells before oxygen–glucose deprivation.
[Scientific Reports]
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Preparation of Catechin Nanoemulsion from Oolong Tea Leaf Waste and Its Inhibition of Prostate Cancer Cells DU-145 and Tumors in Mice

Anti-cancer activity of catechin nanoemulsions prepared from Oolong tea leaf waste was studied on prostate cancer cells DU-145 and DU-145-induced tumors in mice.
[Molecules]
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