caspase-9

[Molecular Cancer Research] A transgenic mouse model expressing human Caspase-9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive MDSCs in contrast to wild-type mice.

[Food and Chemical Toxicology] Researchers studied the photosensitization potential and mechanism involved in dermal phototoxicity of 2,4,5,6-tetraaminopyrimidine sulfate exposed to the dark and UVA/UVB/Sunlight by using different in-chemico and mammalian HaCaT cells, as test systems.

[Biomedicine & Pharmacotherapy] Sphaerococcenol A capacity to impact colorectal-CSCs tumorspheres was evaluated by determining tumorspheres viability, number, and area, as well as the proteasome inhibitory activity.

[Molecular Biotechnology] Researchers probe the role of Sox9 in cardiomyocyte apoptosis after acute myocardial infarction (AMI). AMI cell model was established in AC16 cells by hypoxia treatment.

[Neurochemical Research] Researchers explored the mechanism of hUC-MSC derived exosome's ameliorative effect on the spinal cord injury by combining data from in vivo contusion spinal cord injury model and in vitro cell viability of PC12 cell line stimulated with lipopolysaccharide.

[Molecular Therapy-Methods & Clinical Development] Scientists inserted iCasp9 gene into the endogenous OCT4 locus of human and mouse PSCs without affecting their pluripotency. A chemical inducer of dimerization, AP1903, induced iCasp9 activation, which led to the apoptosis of specific undifferentiated PSCs in vitro and in vivo.