The well-organized, simplistic, and biological route of AgNPs (AgNPs) was synthesized using shrimp shell extracted chitin as reducing, capping and stabilizing factor under the optimized conditions. The anticancer potential of synthesized biogenic AgNPs was evaluated against human hepatocarcinoma cells.
[International Journal of Biological Macromolecules]
Vijayakumar, M., Priya, K., Ilavenil, S., Janani, B., Vedarethinam, V., Ramesh, T., Arasu, M. V., Al-Dhabi, N. A., Kim, Y.-O., & Kim, H.-J. (2020). Shrimp shells extracted chitin in silver nanoparticle synthesis: Expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.10.032Cite
Youn, Y., Lee, J., Kim, J., Kim, J. H., & Hwang, J.-H. (2020). Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells. Scientific Reports, 10(1), 16518. https://doi.org/10.1038/s41598-020-73474-6Cite
Pirali, M., Taheri, M., Zarei, S., Majidi, M., & Ghafouri, H. (2020). Artesunate, as a HSP70 ATPase activity inhibitor, induces apoptosis in breast cancer cells. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.08.198Cite
A genomewide expression analysis in cell lines led scientists to uncover that activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways were the key mediators for the anti-cancer and chemosensitizing effects of andrographis.
Sharma, P., Shimura, T., Banwait, J. K., & Goel, A. (n.d.). Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer. Carcinogenesis. https://doi.org/10.1093/carcin/bgaa090Cite
Cao, C., Sun, G., & Liu, C. (2020). Long non-coding RNA SNHG6 regulates the sensitivity of prostate cancer cells to paclitaxel by sponging miR-186. Cancer Cell International, 20(1), 381. https://doi.org/10.1186/s12935-020-01462-xCite
Researchers used targeted gene editing to introduce the inducible Caspase-9 system into human iPSCs, and then interrogated the efficiency of inducible apoptosis with normal iPSCs as well as diseased iPSCs derived from patients with acute myeloid leukemia.
Scientists showed that IRAK-M, a negative regulator of MyD88 signaling, was deficient or low in melanoma and expression levels correlated with patient survival. Inducing IRAK-M expression using genetic approaches or epigenetic modifiers initiated apoptosis by prompting its interaction with TRAF6.
Geng, D., Ciavattone, N., Lasola, J. J., Shrestha, R., Sanchez, A., Guo, J., Vlk, A., Younis, R., Wang, L., Brown, A. J., Zhang, Y., Velasco-Gonzalez, C., Tan, A.-C., & Davila, E. (2020). Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels. Communications Biology, 3(1), 1–13. https://doi.org/10.1038/s42003-020-1033-yCite