Shrimp Shells Extracted Chitin in Silver Nanoparticle Synthesis: Expanding Its Prophecy towards Anticancer Activity in Human Hepatocellular Carcinoma HepG2 Cells

The well-organized, simplistic, and biological route of AgNPs (AgNPs) was synthesized using shrimp shell extracted chitin as reducing, capping and stabilizing factor under the optimized conditions. The anticancer potential of synthesized biogenic AgNPs was evaluated against human hepatocarcinoma cells.
[International Journal of Biological Macromolecules]
Vijayakumar, M., Priya, K., Ilavenil, S., Janani, B., Vedarethinam, V., Ramesh, T., Arasu, M. V., Al-Dhabi, N. A., Kim, Y.-O., & Kim, H.-J. (2020). Shrimp shells extracted chitin in silver nanoparticle synthesis: Expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.10.032 Cite
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Cdc6 Disruption Leads to Centrosome Abnormalities and Chromosome Instability in Pancreatic Cancer Cells

Cell division cycle 6 (Cdc6)-depleted pancreatic cancer cells significantly inhibited cell proliferation and colony formation, delayed G2/M cell cycle progression, and increased expression of p-histone H3 and cyclin A2 levels.
[Scientific Reports]
Youn, Y., Lee, J., Kim, J., Kim, J. H., & Hwang, J.-H. (2020). Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells. Scientific Reports, 10(1), 16518. https://doi.org/10.1038/s41598-020-73474-6 Cite
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Artesunate, as a HSP70 ATPase Activity Inhibitor, Induces Apoptosis in Breast Cancer Cells

Scientists evaluated the inhibitory effects of artesunate on HSP70 and Bcl-2 expression in two breast cancer cell lines, 4T1 and MCF-7.
[International Journal of Biological Macromolecules]
Pirali, M., Taheri, M., Zarei, S., Majidi, M., & Ghafouri, H. (2020). Artesunate, as a HSP70 ATPase activity inhibitor, induces apoptosis in breast cancer cells. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.08.198 Cite
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Andrographis-Mediated Chemosensitization through Activation of Ferroptosis and Suppression of β-Catenin/Wnt-Signaling Pathways in Colorectal Cancer

A genomewide expression analysis in cell lines led scientists to uncover that activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways were the key mediators for the anti-cancer and chemosensitizing effects of andrographis.
[Carcinogenesis]
Sharma, P., Shimura, T., Banwait, J. K., & Goel, A. (n.d.). Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer. Carcinogenesis. https://doi.org/10.1093/carcin/bgaa090 Cite
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Long Non-Coding RNA SNHG6 Regulates the Sensitivity of Prostate Cancer Cells to Paclitaxel by Sponging miR-186

Small nucleolar RNA host gene 6 (SNHG6) expression was increased and miR-186 expression was reduced in drug-resistant prostate cancer tissues and cells.
[Cancer Cell International]
Cao, C., Sun, G., & Liu, C. (2020). Long non-coding RNA SNHG6 regulates the sensitivity of prostate cancer cells to paclitaxel by sponging miR-186. Cancer Cell International, 20(1), 381. https://doi.org/10.1186/s12935-020-01462-x Cite
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Sufficiency for Inducible Caspase-9 Safety Switch in Human Pluripotent Stem Cells and Disease Cells

Researchers used targeted gene editing to introduce the inducible Caspase-9 system into human iPSCs, and then interrogated the efficiency of inducible apoptosis with normal iPSCs as well as diseased iPSCs derived from patients with acute myeloid leukemia.
[Gene Therapy]
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Induction of IRAK-M in Melanoma Induces Caspase-3 Dependent Apoptosis by Reducing TRAF6 and Calpastatin Levels

Scientists showed that IRAK-M, a negative regulator of MyD88 signaling, was deficient or low in melanoma and expression levels correlated with patient survival. Inducing IRAK-M expression using genetic approaches or epigenetic modifiers initiated apoptosis by prompting its interaction with TRAF6.
[Communications Biology]
Geng, D., Ciavattone, N., Lasola, J. J., Shrestha, R., Sanchez, A., Guo, J., Vlk, A., Younis, R., Wang, L., Brown, A. J., Zhang, Y., Velasco-Gonzalez, C., Tan, A.-C., & Davila, E. (2020). Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels. Communications Biology, 3(1), 1–13. https://doi.org/10.1038/s42003-020-1033-y Cite
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