Differential Expression Profile of Gluten-Specific T Cells Identified by Single-Cell RNA-Seq

In this first single-cell RNA-seq study of tetramer-sorted T cells from untreated celiac disease patients blood, investigators found that gluten-specific T cells showed distinct transcriptomic profiles consistent with activated effector memory T cells that shared features with Th1 and follicular helper T cells.
[PLOS ONE]
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Beyond Celiac Partners with University of Sheffield, UK, to Research Neuropathology of Celiac Disease and Gluten-Related Disorders

Beyond Celiac announced the granting of a two-year established investigator grant award to the University of Sheffield, United Kingdom. The $209,000 investment from Beyond Celiac will make it possible for scientists to expand investigation of the neurological and neuropsychological manifestations of celiac disease and gluten-related disorders.
[Beyond Celiac]
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Synthetic Biologics Provides Update on SYN-020 Intestinal Alkaline Phosphatase Phase 1 Single-Ascending Dose Clinical Trial

Synthetic Biologics, Inc., a clinical-stage company leveraging the microbiome to develop therapeutics designed to prevent and treat gastrointestinal diseases, announced that patient dosing and observation has been completed in its Phase I clinical trial of SYN-020 intestinal alkaline phosphatase.
[Synthetic Biologics, Inc.]
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Potential Impact of Celiac Disease Genetic Risk Factors on T Cell Receptor Signaling in Gluten-Specific CD4+ T Cells

Gluten-specific T cells had a distinct transcriptional profile that mostly resembled that of Th1 cells but also expressed cytokines characteristic of other types of T-helper cells.
[Scientific Reports]
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Anokion Announces Initiation of Multiple-Ascending Dose Portion of its Phase I Clinical Trial with KAN-101 for the Treatment of Celiac Disease

Anokion SA announced that the company has initiated patient dosing in the multiple ascending dose portion of its Assessment of KAN-101 in Celiac Disease disease, a Phase I clinical trial evaluating KAN-101 for the treatment of individuals with celiac disease.
[Anokion SA]
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Circulating CD103+ γδ and CD8+ T Cells Are Clonally Shared with Tissue-Resident Intraepithelial Lymphocytes in Celiac Disease

Scientists obtained γδ and αβ TCR sequences of >2500 single cells from blood and gut of 5 patients, before and during challenge. We observed extensive sharing between blood and gut γδ and CD8+ αβ T-cell clonotypes even prior to gluten challenge.
[Mucosal Immunology]
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Probiomimetics—Novel Lactobacillus‐Mimicking Microparticles Show Anti‐Inflammatory and Barrier‐Protecting Effects in Gastrointestinal Models

A cell‐free and anti‐inflammatory therapeutic system—probiomimetics—based on membrane vesicles of probiotic bacteria coupled to the surface of microparticles was developed.
[Small]
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