CAR-T Cell Therapy: Current Limitations and Potential Strategies

Scientists discuss recent innovations in CAR-T cell engineering to improve clinical efficacy in both hematological malignancy and solid tumors and strategies to overcome limitations of CAR-T cell therapy in both hematological malignancy and solid tumors.
[Blood Cancer Journal]
Sterner, R. C., & Sterner, R. M. (2021). CAR-T cell therapy: current limitations and potential strategies. Blood Cancer Journal, 11(4), 1–11. https://doi.org/10.1038/s41408-021-00459-7 Cite
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Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in the Race against Cancer

Researchers review the advantages, challenges, and preclinical and clinical research advances in CAR NK cell engineering for cancer immunotherapy.
[Cancer Discovery]
Daher, M., & Rezvani, K. (2020). Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in the Race against Cancer. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-0556 Cite
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Dr. Stanley Riddell awarded Burke O’Reilly Family Endowed Chair in Immunotherapy

Riddell’s lab is working to make CAR T-cell therapies even better and expand the repertoire of cancers it can treat. Based out of the Hutch’s new Steam Plant facility, he and his colleagues are zeroing in on multiple myeloma as the next likely new target for the approach.
[Fred Hutchinson Cancer Research Center]
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A Comprehensive Library of Human Transcription Factors for Cell Fate Engineering

Scientists demonstrated orthogonal programming by including oligodendrocyte-inducible hPSCs with unmodified hPSCs to generate cerebral organoids, which expedited in situ myelination.
[Nature Biotechnology]
Ng, A. H. M., Khoshakhlagh, P., Rojo Arias, J. E., Pasquini, G., Wang, K., Swiersy, A., Shipman, S. L., Appleton, E., Kiaee, K., Kohman, R. E., Vernet, A., Dysart, M., Leeper, K., Saylor, W., Huang, J. Y., Graveline, A., Taipale, J., Hill, D. E., Vidal, M., … Church, G. M. (2020). A comprehensive library of human transcription factors for cell fate engineering. Nature Biotechnology, 1–10. https://doi.org/10.1038/s41587-020-0742-6 Cite
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Persistent STAT5 Activation Reprograms the Epigenetic Landscape in CD4+ T Cells to Drive Polyfunctionality and Antitumor Immunity

Researchers report that persistent activation of signal transducer and activator of transcription 5 in tumor-specific CD4+ T cells drives the development of polyfunctional T cells.
[Science Immunology]
Ding, Z.-C., Shi, H., Aboelella, N. S., Fesenkova, K., Park, E.-J., Liu, Z., Pei, L., Li, J., McIndoe, R. A., Xu, H., Piazza, G. A., Blazar, B. R., Munn, D. H., & Zhou, G. (2020). Persistent STAT5 activation reprograms the epigenetic landscape in CD4+ T cells to drive polyfunctionality and antitumor immunity. Science Immunology, 5(52). https://doi.org/10.1126/sciimmunol.aba5962 Cite
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