cell proliferation

[Oncogene] The tumor suppressing effects of MPDZ were determined in vitro and in vivo. The target molecules and signaling pathway that mediated the function of MPDZ were also identified.

[Ebiomedicine] Investigators studied effects of recombinant D-dopachrome tautomerase (DDT) on cell proliferation and survival by clonogenic assay and annexin V-PI staining respectively. DDT-induced signaling was investigated by Western blot.

[Biochemical Genetics] Min6 cells were induced by 5 mg/dl UA and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and glucose-stimulated insulin secretion, respectively.

[Molecular Therapy-Nucleic Acids] The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.

[Laboratory Investigation] A downregulation of SNHG15 was observed in the ischemic hind limb of diabetic mice and high glucose-treated HUVECs.

[Molecular Cancer Research] Researchers provided in vivo evidence that RAD51-Associated Protein 1(RAD51AP1) played a critical role in colorectal cancer (CRC) growth and drug resistance by regulating CRC stem cell self-renewal.