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cell proliferation

Antagonism of the Transient Receptor Potential Melastatin-2 Channel Leads to Targeted Antitumor Effects in Primary Human Malignant Melanoma Cells

[International Journal of Oncology] Researchers determined the effects of antagonism of the transient receptor potential melastatin‑2 ion channel in primary human malignant melanoma cells.

LncRNA XIST Engages in Psoriasis via Sponging MiR-338-5p to Regulate Keratinocyte Proliferation and Inflammation

[Skin Pharmacology and Physiology] Scientists investigated the role and regulatory relationship between long noncoding RNA (lncRNA) XIST and miR-338-5p in psoriatic patients and cell models.

TRPM2-AS Promotes Paclitaxel Resistance in Prostate Cancer by Regulating FOXK1 via Sponging miR-497-5p

[Drug Development Research] Transient receptor potential cation channel subfamily M member 2 antisense RNA (TRPM2-AS) knockdown suppressed cell progression and paclitaxel (PTX) resistance in PTX-resistant prostate cancer cells by miR-497-5p/FOXK1 axis.

Human Infrapatellar Fat Pad Mesenchymal Stem Cells Show Immunomodulatory Exosomal Signatures

[Scientific Reports] Scientists hypothesized that infrapatellar fat pad-derived MSCs robust immunomodulatory therapeutic effects were largely exerted via their exosomal secretome by attenuating synoviocytes and macrophages pro-inflammatory activation.

Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis

[Molecular Cancer Research] Scientists reported a gatekeeper function of the Ras/Erk and NF-κB pathways pathways by working in synergy to suppress liver tumorigenesis.

3-Mercaptopyruvate Sulfurtransferase Represses Tumor Progression and Predicts Prognosis in Hepatocellular Carcinoma

[Liver International] 3-Mercaptopyruvate sulfurtransferase (MPST) protein expression was analyzed in HCC tumor tissues and matched adjacent tissues. The effect of MPST on HCC progression was studied in vitro and in vivo.

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