Anlotinib Suppresses Tumor Progression via Blocking the VEGFR2/PI3K/Akt Cascade in Intrahepatic Cholangiocarcinoma

Using in vitro experiments, investigators found that anlotinib had significant effects on proliferation inhibition, migration and invasion restraint, and cell-cycle arrestment in intrahepatic cholangiocarcinoma.
[Cell Death & Disease]
Song, F., Hu, B., Cheng, J.-W., Sun, Y.-F., Zhou, K.-Q., Wang, P.-X., Guo, W., Zhou, J., Fan, J., Chen, Z., & Yang, X.-R. (2020). Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinoma. Cell Death & Disease, 11(7), 1–14. https://doi.org/10.1038/s41419-020-02749-7 Cite
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LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis

Scientists showed that LEFTY1, a secreted inhibitor of NODAL/SMAD2 signaling, was produced by mammary progenitor cells and, concomitantly, suppresses SMAD2 and SMAD5 signaling to promote long-term proliferation of normal and malignant mammary epithelial cells.
[Cell Stem Cell]
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Therapeutic Inhibition of FcγRIIb Signaling Targets Leukemic Stem Cells in Chronic Myeloid Leukemia

Scientists describe the immunoreceptor tyrosine-based inhibition motif-containing Fc gamma receptor IIb for being critical in leukemic stem cell resistance and showed that targeting FcγRIIb downstream signaling, by using a Food and Drug Administration-approved BTK inhibitor, provides a successful therapeutic approach.
[Leukemia]
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Antimalarial Agent Artesunate Induces G0/G1 Cell Cycle Arrest and Apoptosis via Increasing Intracellular ROS Levels in Normal Liver Cells

Researchers investigated the possible cytotoxic effects using normal BRL-3A and AML12 liver cells.
[Human & Experimental Toxicology]
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DDX5-Targeting Fully Human Monoclonal Autoantibody Inhibits Proliferation and Promotes Differentiation of Acute Promyelocytic Leukemia Cells by Increasing ROS Production

2F5 was confirmed to induce G0/G1 phase arrest in acute promyelocytic leukemia (APL) cells, and promoted APL cell differentiation combined with decreased DDX5 expression and increased reactive oxygen species production. Knockdown of DDX5 by siRNA also inhibited proliferation, promoted cell differentiation and enhanced ROS production in APL cells.
[Cell Death & Disease]
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Impaired Mitochondrial Oxidative Phosphorylation Limits the Self-Renewal of T Cells Exposed to Persistent Antigen

Scientists showed that persistent antigenic stimulation impaired ADP-coupled oxidative phosphorylation.
[Nature Immunology]
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Proliferative Classification of Intracranially Injected HER2-Positive Breast Cancer Cell Lines

In this study, the researchers performed intracranial injection using nine HER2-positive breast cancer cell lines to evaluate their proliferative activity in brain tissue.
[Cancers]
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