Matrix Metalloproteinase 11 (MMP11) in Macrophages Promotes the Migration of HER2-Positive Breast Cancer Cells and Monocyte Recruitment through CCL2–CCR2 Signaling

Based on the immunohistochemical analysis of breast cancer tissues from 497 patients, the authors demonstrated that matrix metalloproteinase 11 (MMP11) expression in mononuclear inflammatory cells was an independent negative prognostic factor in breast cancer, whereas MMP11 expression in tumor cells and fibroblasts was not associated with patient survival.
[Laboratory Investigation]
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ROR2 Has a Protective Role in Melanoma by Inhibiting Akt Activity, Cell-Cycle Progression, and Proliferation

The role of Receptor tyrosine kinase-like orphan receptor 2 (ROR2) in tumor growth was assessed in xenotransplantation experiments followed by immunohistochemistry analysis of the tumors.
[Journal of Biomedical Science]
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Tumor Suppressor LHX6 Upregulation Contributes to the Inhibitory Effect of miR-346 Knockdown on Colorectal Cancer Cell Growth

Dysregulated miRNAs have been promulgated as oncogenes or tumor-suppressive genes participating in the initiation and progression of colorectal cancer (CRC). Scientists reported that miR-346 was highly expressed in CRC patients.
[Environmental Toxicology]
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Loss of Aryl Hydrocarbon Receptor Suppresses the Response of Colonic Epithelial Cells to IL22 Signaling by Upregulating SOCS3

Scientists showed that IL22 treatment induced the phosphorylation of STAT3, inhibited colonic organoid growth, and promoted colonic cell proliferation in vivo.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
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The Protein Kinase Activity of NME7 Activates Wnt/β-Catenin Signaling to Promote One-Carbon Metabolism in Hepatocellular Carcinoma

High-throughput RNA-seq was used to identify the differentially expressed circRNAs upon IL-6 stimulation in intrahepatic cholangiocarcinoma cells.
[Hepatology]
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Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells

Researchers identified the cell surface binding partner of Reg4 and dissected its role in colorectal cancer (CRC) and pancreatic cancer (PC) growth and stem cell survival. In vitro models of human CRC and PC were used to evaluate the results.
[Molecular Cancer Research]
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Macrophage-Mediated RON Signaling Supports Breast Cancer Growth and Progression through Modulation of IL-35

Researchers showed that the activation of the RON receptor tyrosine kinase signaling pathway specifically in macrophages supports breast cancer growth and metastasis.
[Oncogene]
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TCP1 Increases Drug Resistance in Acute Myeloid Leukemia by Suppressing Autophagy via Activating AKT/mTOR Signaling

Scientists discovered that the T-complex protein 1 (TCP1) expression was elevated in acute myeloid leukemia patients and high TCP1 expression was associated with low complete response rate along with poor overall survival.
[Cell Death & Disease]
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The IL-3, IL-5, and GM-CSF Common Receptor Beta Chain Mediates Oncogenic Activity of FLT3-ITD-Positive AML

Researchers discovered that FMS-like Tyrosine Kinase 3 (FLT3)-internal tandem duplication (ITD) directly binded to CSF2RB in acute myeloid leukemia (AML) cell lines and blasts isolated from AML patients.
[Leukemia]
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Rare t(X; 14)(q28; q32) Translocation Reveals Link between MTCP1 and Chronic Lymphocytic Leukemia

Scientists reported overexpression of human mature T cell proliferation 1 gene (MTCP1) restricted to the B cell compartment in mice produced a clonal CD5+/CD19+ leukemia recapitulating the major characteristics of human chronic lymphocytic leukemia.
[Nature Communications]
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Arl4c Promotes the Growth and Drug Resistance of Pancreatic Cancer by Regulating Tumor-Stromal Interactions

Researchers examined the proliferation and drug resistance effect of ADP-ribosylation factor like-4c (Arl4c) on pancreatic cancer cells. They explored the contribution of Arl4c high expression in pancreatic stellate cell activation.
[iScience]
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