Transformation of SOX9+ Cells by Pten Deletion Synergizes with Steatotic Liver Injury to Drive Development of Hepatocellular and Cholangiocarcinoma

Researchers employed lineage-tracing to demonstrate the tumorigenicity potential of the Pten-, SOX9+ cells. They showed that these cells were capable of giving rise to mixed-lineage tumors that manifested features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CCA).
[Scientific Reports]
Chen, J., Debebe, A., Zeng, N., Kopp, J., He, L., Sander, M., & Stiles, B. L. (2021). Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma. Scientific Reports, 11(1), 11823. https://doi.org/10.1038/s41598-021-90958-1 Cite
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Microarray Analysis Reveals ONC201 Mediated Differential Mechanisms of Chop Gene Regulation in Metastatic and Nonmetastatic Colorectal Cancer Cells

The authors investigated the signaling pathways through which ONC201/CHOP crosstalk was regulated in ONC201-treated nonmetastatic and metastatic colorectal cancer cell lines.
[Scientific Reports]
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LncRNA PART1 Promotes Proliferation and Migration, Is Associated with Cancer Stem Cells, and Alters the miRNA Landscape in Triple-Negative Breast Cancer

Researchers demonstrated that long non-coding RNA prostate androgen regulated transcript 1 (PART1) was enriched in TNBCs. Knockdown of PART1 in TNBC cell lines and a patient-derived xenograft decreased cell proliferation, migration, tumor growth, and mammosphere formation potential.
[Cancers]
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Contraceptive Progestins with Androgenic Properties Stimulate Breast Epithelial Cell Proliferation

Using mouse mammary tissue ex vivo, scientists showed that testosterone-related progestins induced the progesterone receptor (PR) target and mediator of PR signaling-induced cell proliferation receptor activator of NF-κB ligand, whereas progestins with anti-androgenic properties in reporter assays did not.
[EMBO Molecular Medicine]
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Stable Duplex-Linked Antisense Targeting miR-148a Inhibits Breast Cancer Cell Proliferation

Researchers performed a knockdown of miR-148a using anti-miRNA oligonucleotides (AMOs) and investigated the effect on breast cancer cell proliferation, which was significantly suppressed by AMO flanked by interstrand cross-linked duplexes, whereas single-stranded AMOs had no effect.
[Scientific Reports]
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Role of Cytoplasmic Localization of Maspin in Promoting Cell Invasion in Breast Cancer with Aggressive Phenotype

Scientists studied the biological function of cytoplasmic maspin in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus.
[Scientific Reports]
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Generation of Tetracycline-Controllable CYP3A4-Expressing Caco-2 Cells by the piggyBac Transposon System

Investigators generated CYP3A4-expressing Caco-2 cells and attempted to establish a model that could simultaneously evaluate drug absorption and metabolism.
[Scientific Reports]
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KLHL38 Involvement in Non-Small Cell Lung Cancer Progression via Activation of the Akt Signaling Pathway

Scientists clarified the role of KLHL38 in non-small cell lung cancer (NSCLC). KLHL38 expression was evaluated in tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry and real-time PCR, and its association with clinicopathological parameters was analyzed.
[Cell Death & Disease]
Xu, Y., Wang, C., Jiang, X., Zhang, Y., Su, H., Jiang, J., Ren, H., & Qiu, X. (2021). KLHL38 involvement in non-small cell lung cancer progression via activation of the Akt signaling pathway. Cell Death & Disease, 12(6), 1–14. https://doi.org/10.1038/s41419-021-03835-0 Cite
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GABARAP Ameliorates IL-1β-Induced Inflammatory Responses and Osteogenic Differentiation in Bone Marrow-Derived Stromal Cells by Activating Autophagy

Researchers investigated whether pro-autophagic γ-aminobutyric acid receptor-associated protein (GABARAP) promoted bone MSCs proliferation and osteogenic differentiation by modulating autophagy in the presence or absence of interleukin-1 beta (IL-1β) in vitro.
[Scientific Reports]
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Resveratrol Attenuates the Proliferation of Prostatic Stromal Cells in Benign Prostatic Hyperplasia by Regulating Cell Cycle Progression, Apoptosis, Signaling Pathways, BPH Markers, and NF-κB Activity

Investigators evaluated the inhibitory effects of resveratrol on cell proliferation associated with prostatic hyperplasia using WPMY-1 cells.
[International Journal of Molecular Sciences]
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3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in a Nutritionally Deficient Environment

PMNT was confirmed to promote human umbilical cord-derived MSC proliferation in a serum-free medium by driving cell cycles and up-regulating gene expression in the pathways of biosynthesis and the metabolism.
[ACS Applied Materials & Interfaces]
Zhao, H., Xu, J., Zhang, E., Qi, R., Huang, Y., Lv, F., Liu, L., Gu, Q., & Wang, S. (2021). 3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in a Nutritionally Deficient Environment. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.1c04967 Cite
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