Derivatives of Gecko Cathelicidin-Related Antioxidant Peptide Facilitate Skin Wound Healing

Two truncated peptides, Gj-CATH3-(38–42)-peptide and Gj-CATH3-(33–42)-peptide induced HaCaT cell proliferation and prevent decreases in SOD activity and increases of MDA concentration in injured-skin tissue.
[European Journal of Pharmacology]
Derivatives of gecko cathelicidin-related antioxidant peptide facilitate skin wound healing - ScienceDirect. (n.d.). Retrieved October 16, 2020, from https://www.sciencedirect.com/science/article/abs/pii/S001429992030741X?via%3Dihub Cite
Abstract
Bookmark

No account yet? Register

0
Share

Combination of rAd-p53 In Situ Gene Therapy and Anti-PD-1 Antibody Immunotherapy Induced Anti-Tumor Activity in Mouse Syngeneic Urogenital Cancer Models

Researchers undertook a novel combination therapy using rAd-p53 in situ gene therapy and immunotherapy with immune checkpoint inhibitor anti-PD-1 antibody for urogenital cancers. Three mouse syngeneic tumor cell lines, TRAMP-C2 (prostate), MBT-2 (bladder) and Renca (kidney) were used.
[Scientific Reports]
Kunimura, N., Kitagawa, K., Sako, R., Narikiyo, K., Tominaga, S., Bautista, D. S., Xu, W., Fujisawa, M., & Shirakawa, T. (2020). Combination of rAd-p53 in situ gene therapy and anti-PD-1 antibody immunotherapy induced anti-tumor activity in mouse syngeneic urogenital cancer models. Scientific Reports, 10(1), 17464. https://doi.org/10.1038/s41598-020-74660-2 Cite
Full Article
Bookmark

No account yet? Register

0
Share

LncRNA SNHG11 Promotes Gastric Cancer Progression by Activating Wnt/β-Catenin Pathway and Oncogenic Autophagy

Long non-coding RNA small nucleolar host gene 11 (SNHG11) post-transcriptionally upregulated catenin beta 1 and autophagy related 12 through miR-483-3p/miR-1276, while the processing of pre-miR-483/pre-miR-1276 was hindered by SNHG11. SNHG11 induced GSK-3β ubiquitination through interacting with Cullin 4A to further activate the Wnt/β-catenin pathway.
[Molecular Therapy]
LncRNA SNHG11 promotes gastric cancer progression by activating Wnt/β-catenin pathway and oncogenic autophagy: Molecular Therapy. (n.d.). Retrieved October 15, 2020, from https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30545-1 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Dystrophin Dp71ab Is Monoclonally Expressed in Human Satellite Cells and Enhances Proliferation of Myoblast Cells

Dp71ab, but not Dp71, was found to be a molecular enhancer of myoblast proliferation and transfection with Dp71ab may generate a high yield of stem cells for Duchenne muscular dystrophy treatment.
[Scientific Reports]
Farea, M., Rani, A. Q. M., Maeta, K., Nishio, H., & Matsuo, M. (2020). Dystrophin Dp71ab is monoclonally expressed in human satellite cells and enhances proliferation of myoblast cells. Scientific Reports, 10(1), 17123. https://doi.org/10.1038/s41598-020-74157-y Cite
Full Article
Bookmark

No account yet? Register

0
Share

The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG

Scientists demonstrated a unique role for liver in modulating the pathogenesis of leukemic disease and suggest that the hepatic microenvironment may protect leukemia cells from chemotherapeutic challenge.
[Cancer Discovery]
The hepatic microenvironment uniquely protects leukemia cells through induction of growth and survival pathways mediated by LIPG | Cancer Discovery. (n.d.). Retrieved October 13, 2020, from https://cancerdiscovery.aacrjournals.org/content/early/2020/10/07/2159-8290.CD-20-0318 Cite
AbstractFull Article
Bookmark

No account yet? Register

0
Share

Tideglusib Attenuates Growth of Neuroblastoma Cancer Stem/Progenitor Cells In Vitro and In Vivo by Specifically Targeting GSK-3β

Investigators evaluated the potential anti-tumor effect of Tideglusib, an irreversible glycogen synthase kinase (GSK)-3β inhibitor drug, on three human neuroblastoma cell lines, SK-N-SH, SH-SY5Y, and IMR-32.
[Pharmacological Reports]
Bahmad, H. F., Chalhoub, R. M., Harati, H., Bou-Gharios, J., Assi, S., Ballout, F., Monzer, A., Msheik, H., Araji, T., Elajami, M. K., Ghanem, P., Chamaa, F., Kadara, H., Abou-Antoun, T., Daoud, G., Fares, Y., & Abou-Kheir, W. (2020). Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β. Pharmacological Reports. https://doi.org/10.1007/s43440-020-00162-7 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Ribonuclease 7-Driven Activation of ROS1 Is a Potential Therapeutic Target in Hepatocellular Carcinoma

Oncogenic function of RNase7 was analyzed by cell proliferation, migration, invasion assays and xenograft mouse model. The anti-ROS1 inhibitor treatment efficacy was evaluated in hepatocellular carcinoma patient-derived xenograft and orthotopic models.
[Journal of Hepatology]
Liu, C., Zha, Z., Zhou, C., Chen, Y., Xia, W., Wang, Y.-N., Lee, H.-H., Yin, Y., Yan, M., Chang, C.-W., Chan, L.-C., Qiu, Y., Li, H., Li, C.-W., Hsu, J.-M., Hsu, J. L., Wang, S.-C., Ren, N., & Hung, M.-C. (2020). Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma. Journal of Hepatology, 0(0). https://doi.org/10.1016/j.jhep.2020.09.030 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

CD19-Specific CAR-T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor is Effective in Patients with PD-L1 Positive B-Cell Lymphoma

Scientists generated a novel anti-CD19 CAR expressing PD-1/CD28 chimeric switch-receptor. They then conducted a Phase Ib study to evaluate safety and efficacy of CD19-PD-1/CD28-CAR T cells in the treatment of PD-L1+ B-cell lymphoma.
[Clinical Cancer Research]
Liu, H., Lei, W., Zhang, C., Yang, C., Wei, J., Guo, Q., Guo, X., Chen, Z., Lu, Y., Young, K. H., Lu, Z., & Qian, W. (2020). CD19-Specific CAR-T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor is Effective in Patients with PD-L1 Positive B-Cell Lymphoma. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-1457 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Polydeoxyribonucleotide-Delivering Therapeutic Hydrogel for Diabetic Wound Healing

In vitro studies using human dermal fibroblasts and diabetes mellitus fibroblasts and an in ovo chorioallantoic membrane assay confirmed that the Alg-PDRN hydrogel effectively induced cell proliferation and expression of angiogenic growth factors and promoted new blood vessel formation.
[Scientific Reports]
Shin, D. Y., Park, J.-U., Choi, M.-H., Kim, S., Kim, H.-E., & Jeong, S.-H. (2020). Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing. Scientific Reports, 10(1), 16811. https://doi.org/10.1038/s41598-020-74004-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

ROCK Inhibitor Combined With Ca2+

Investigators showed that the combination of Rho-associated kinase (ROCK) inhibition with Ca2+ elevation regulated the phosphorylation of myosin light chain II and improved both cell expansion and cell–cell adhesion during the culture of human nasal mucosal epithelial cell sheets.
[Scientific Reports]
ROCK inhibitor combined with Ca 2+ controls the myosin II activation and optimizes human nasal epithelial cell sheets | Scientific Reports. (n.d.). Retrieved October 8, 2020, from https://www.nature.com/articles/s41598-020-73817-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

ARHGEF19 Regulates MAPK/ERK Signaling and Promotes the Progression of Small Cell Lung Cancer

Enforced ARHGEF19 expression promotes small cell lung cancer cell proliferation in vitro and its knockdown decreases cell proliferation in vitro and in vivo.
[Biochemical and Biophysical Research Communications]
Abstract
Bookmark

No account yet? Register

0
Share
Share