cell proliferation

[Scientific Reports] The authors found that a small molecule phenylbutenoid dimer NMac1, a previously identified anti-metastatic agent, had novel anti-proliferative effect only under glucose starvation in metastatic breast cancer cells.

[Military Medical Research] Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.

[JCI Insight] Scientists identified the senescence-like characteristics of cancer-associated fibroblasts (CAFs) after RT and clarify the formidable ability of senescence-like CAFs in promoting NSCLC cell proliferation and radioresistance through the JAK/STAT pathway.

[Nature Communications] The secreted protein growth and differentiation factor 1 (GDF1) was found to be closely associated with poor tumour differentiation. Overexpression of GDF1 suppressed cell proliferation but strongly enhanced tumour dissemination and metastasis.

[Scientific Reports] Scientists generated UM-002, a novel brain penetrant bromodomain and extraterminal domain (BET) inhibitor that reduced glioblastoma cell proliferation in vitro and in a human cerebral brain organoid model.

[Biofactors] A series of experiments were performed to systematically investigate the cellular behavior of growth hormone (GH)/GH receptor (GHR) in MSCs, and the results showed that GH/GHR not only internalized into the cytoplasm, but also transported into the cell nuclei of MSCs.