cell proliferation

[Cell Death Discovery] Scientists found that specific deletion of Cbl-b and c-Cbl in CD11c+ cells, predominantly in dendritic cells (DCs), led to liver fibrosis, cirrhosis, and accumulation of systemic conventional Type I DCs due to enhanced cell proliferation and decreased cell apoptosis.

[Cancer Gene Therapy] TRPV1 expression in tumor tissues, primary cells and cell lines of lung adenocarcinoma, as well as the mechanism mediating its hyperexpression were systematically studied.

[Cell Death & Disease] Investigators found that tripartite motif (TRIM) 46 promoted lung adenocarcinoma cell proliferation and cisplatin resistance by enhancing glycolysis.

[Thoracic Cancer] Inhibition of progression of lung cancer cells induced by heterogeneous nuclear ribonucleoprotein K-knockdown was dependent on activation of p53 by the p53/p21/cyclin D1 pathway.

[Cell Death Discovery] Researchers analyzed the expression of α7nAchR in human and mouse psoriatic skin tissue. In vivo, PNU-282987 or Methyllycaconitine, a specific agonist or antagonist of α7nAchR, were administered to imiquimod-induced psoriatic mouse models.

[Cell Death & Disease] Investigators found that N-(3-aminopropyl)-2-[(3-methylphenyl) methoxy]-N-(2-thienylmethyl) benzamide hydrochloride (AMTB) suppressed osteosarcoma cell proliferation, metastasis and induced cellular apoptosis.