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cell proliferation

ECHS1, an Interacting Protein of LASP1, Induces Sphingolipid-Metabolism Imbalance to Promote Colorectal Cancer Progression by Regulating Ceramide Glycosylation

[Cell Death & Disease] Through an LC–MS assay, LIM and SH3 protein 1 (LASP1) was identified as a sphingolipid-metabolism-involved protein, and short-chain enoyl-CoA hydratase (ECHS1) was identified as a new LASP1-interacting protein through a protein assay in colorectal cancer.

DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression Via the MAPK/ERK/MMP2 Pathway

[Molecular Cancer Research] Researchers found that the expression of DCLK1 isoform 4 (DCLK1-S) was significantly increased in human esophageal squamous cell carcinoma tissues and associated with malignant progression and poor prognosis.

Oncogenic Activity of Glucocorticoid Receptor β Is Controlled by Ubiquitination-Dependent Interaction with USP49 in Glioblastoma Cells

[Molecular Cancer Research] By establishing a C-terminal deletion mutant, scientists determined that glucocorticoid receptor β (GRβ) can be ubiquitinated. They also found that its C-terminal was essential for this ubiquitination

Aberrantly Reduced Expression of miR-342-5p Contributes to CCND1-Associated Chronic Myeloid Leukemia Progression and Imatinib Resistance

[Cell Death & Disease] Scientists used next-generation sequencing to explore endogenous miRNAs in chronic myeloid leukemia (CML) patients versus healthy volunteers, and miR-342-5p was identified as the primary target. They found that miR-342-5p was downregulated in CML patients and had a significant inhibitory effect on cell proliferation in CML.

SETD8 Induces Stemness and Epithelial–Mesenchymal Transition of Pancreatic Cancer Cells by Regulating ROR1 Expression

[Acta Biochimica Et Biophysica Sinica] SETD8 mediated receptor tyrosine kinase-like orphan receptor 1 (ROR1) activity and regulated pancreatic cancer cells invasion and migration, although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.

Human Cardiac Stem Cells Rejuvenated by Modulating Autophagy with MHY-1685 Enhance the Therapeutic Potential for Cardiac Repair

[Experimental and Molecular Medicine] Scientists employed MHY-1685, a novel mammalian target of rapamycin inhibitor, and examined its long-term priming effect on the activities of senile human cardiac stem cells (hCSCs) and the functional benefits of primed hCSCs after transplantation.

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