cell proliferation

[Signal Transduction and Targeted Therapy] The authors reported a novel function of factor Kinectin 1 (KTN1) as a carcinogenic promoter in TNBC. KTN1 expression in TNBC was increased compared with adjacent tissues or luminal or Her2 subtypes of breast cancer, and TNBC patients with high KTN1 expression had poor prognosis.

[Scientific Reports] Researchers developed bispecific antibodies for T-cell retargeting to HER3-expressing tumor cells, utilizing either a single-chain diabody format (scDb) with one binding site for HER3 and one for CD3 on T-cells or a trivalent bispecific scDb-scFv fusion protein exhibiting an additional binding site for HER3.

[Molecular Therapy-Nucleic Acids] Investigators review the current findings on the potential of circular RNAs (circRNAs) as a diagnostic, prognostic, and therapeutic biomarker for TNBC, and discuss the current limitations and future directions of TNBC-associated circRNAs, which can facilitate the translation of experimental research into clinical application.

[Cell Death & Disease] The authors revealed a series of key pathways and hub long non-coding RNAs involved in the malignant transformation of gastrointestinal stromal tumors (GISTs). DNM3OS promoted GIST cell proliferation and mitosis by regulating the expression of GLUT4 and CD36.

[Auris Medical Holding Ltd.] Auris Medical Holding Ltd. announced the selection of mutant KRAS-driven colorectal cancer as the first therapeutic indication for its OligoPhore™ oligonucleotide delivery platform, based on outcomes from studies with OligoPhore™ enabled KRAS silencing, and a well-defined regulatory and development pathway.

[Cell Reports] Researchers reported that Ewing sarcoma cells were dependent on the autocrine signaling mediated by NELL2, a secreted glycoprotein that has been characterized as an axon guidance molecule.