AP-1 Is a Temporally Regulated Dual Gatekeeper of Reprogramming to Pluripotency

Scientists examined epigenome remodeling at the onset of human nuclear reprogramming by profiling human fibroblasts after fusion with murine ESCs. Efficient reprogramming of human fibroblasts to iPSCs was achieved by transduction with vectors expressing SOX2, KLF4, and inducible dnAP-1, demonstrating that dnAP-1 can substitute for exogenous human OCT4.
[Proceedings of the National Academy of Sciences of the United States of America]
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The Therapeutic Potential of Multiclonal Tumoricidal T Cells Derived from Tumor Infiltrating Lymphocyte-1 derived iPS Cells

Researchers established tumor-specific tumor-infiltrating lymphocytes (TIL)-derived iPS cells with human colorectal cancer specimens to confirm their hypothesis that the anti-tumor effect could be enhanced by TIL regeneration.
[Communications Biology]
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XCR1+ Type 1 Conventional Dendritic Cells Drive Liver Pathology in Non-alcoholic Steatohepatitis

Researchers identified a significant pathology-associated increase in hepatic conventional dendritic cells (cDC) and further defined their source as non-alcoholic fatty liver disease-induced boost in cycling of cDC progenitors in the bone marrow.
[Nature Medicine]
Deczkowska, A., David, E., Ramadori, P., Pfister, D., Safran, M., At The, B., Giladi, A., Jaitin, D. A., Barboy, O., Cohen, M., Yofe, I., Gur, C., Shlomi-Loubaton, S., Henri, S., Suhail, Y., Qiu, M., Kam, S., Hermon, H., Lahat, E., … Amit, I. (2021). XCR1 + type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis. Nature Medicine, 1–12. https://doi.org/10.1038/s41591-021-01344-3 Cite
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Insulin-Positive Ductal Cells Do Not Migrate Into Preexisting Islets during Pregnancy

Researchers used a cell-tagging dye, CFDA-SE, to permanently label pancreatic duct cells through an intraductal infusion technique.
[Experimental and Molecular Medicine]
Liu, Q., Jiang, Y., Zhu, L., Qian, J., Wang, C., Yang, T., Prasadan, K., Gittes, G. K., & Xiao, X. (2021). Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy. Experimental & Molecular Medicine, 1–10. https://doi.org/10.1038/s12276-021-00593-z Cite
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Sensing Serotonin Secreted from Human Serotonergic Neurons Using Aptamer-Modified Nanopipettes

Investigators generated human serotonergic neurons in vitro and detected secreted serotonin using aptamer-coated nanopipettes in a low nanomolar range, with the possibility of detecting significantly lower concentrations.
[Molecular Psychiatry]
Nakatsuka, N., Heard, K. J., Faillétaz, A., Momotenko, D., Vörös, J., Gage, F. H., & Vadodaria, K. C. (2021). Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. Molecular Psychiatry, 1–11. https://doi.org/10.1038/s41380-021-01066-5 Cite
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Exacis Biotherapeutics Develops mRNA-Engineered iPSC-Derived NK Cells For Difficult-To-Treat Tumors

Exacis Biotherapeutics Inc., announced several important steps in the preclinical development of its ExaNK engineered NK cell-therapy candidates.
[Exacis Biotherapeutics Inc. (PR Newswire LLC.)]
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Regional Specification and Complementation with Non-neuroectodermal Cells in Human Brain Organoids

The authors highlight recent advances of neuronal organoid technologies, focusing on the region-specific brain organoids and complementation with endothelial cells and microglia
[Journal of Molecular Medicine]
Tanaka, Y., & Park, I.-H. (2021). Regional specification and complementation with non-neuroectodermal cells in human brain organoids. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-021-02051-9 Cite
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In Vivo Chemical Reprogramming of Astrocytes Into Neurons

Investigators demonstrated that in the adult mouse brain, small molecules could reprogram astrocytes into neurons.
[Cell Discovery]
Ma, Y., Xie, H., Du, X., Wang, L., Jin, X., Zhang, Q., Han, Y., Sun, S., Wang, L., Li, X., Zhang, C., Wang, M., Li, C., Xu, J., Huang, Z., Wang, X., Chai, Z., & Deng, H. (2021). In vivo chemical reprogramming of astrocytes into neurons. Cell Discovery, 7(1), 1–13. https://doi.org/10.1038/s41421-021-00243-8 Cite
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A Synthetic mRNA Cell Reprogramming Method Using CYCLIN D1 Promotes DNA Repair Generating Improved Genetically Stable Human Induced Pluripotent Stem Cells

Investigators demonstrated that CYCLIN D1 made induced pluripotent stem cells have lower multitelomeric signal, reduced double‐strand DNA breaks, correct nuclear localization of RAD51 protein expression, and reduced SNP changes per chromosome, compared with the classical reprogramming method using C‐MYC.
[Stem Cells]
Alvarez‐Palomo, A. B., Requena‐Osete, J., Delgado‐Morales, R., Moreno‐Manzano, V., Grau‐Bove, C., Tejera, A. M., Otero, M. J., Barrot, C., Santos‐Barriopedro, I., Vaquero, A., Mezquita‐Pla, J., Moran, S., Naya, C. H., Garcia‐Martínez, I., Pérez, F. V., Blasco, M. A., Esteller, M., & Edel, M. J. (n.d.). A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair generating improved genetically stable human induced pluripotent stem cells. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3358 Cite
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DNA Methylation Status Correlates with Adult β-Cell Regeneration Capacity

Scientists report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished.
[npj Regenerative Medicine]
Khurana, I., Al-Hasani, K., Maxwell, S., K.n, H., Okabe, J., Cooper, M. E., Collombat, P., & El-Osta, A. (2021). DNA methylation status correlates with adult β-cell regeneration capacity. Npj Regenerative Medicine, 6(1), 1–5. https://doi.org/10.1038/s41536-021-00119-1 Cite
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Leading Innovators Collaborate to Provide New, Patient Representative Cell Culture Solutions for Smarter In Vitro Research

One of the biggest challenges in drug development and personalized medicine is how to model the cellular microenvironment accurately. Cellaria and BioLamina are pursuing this challenge by collaborating to develop more defined reprogramming methods, large-scale iPSC expansions, and lineage differentiation for human cells and animal cells for vertebrate and non-vertebrate species.
[Cellaria Inc. and BioLamina (Businesswire, Inc.)]

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