MAP2K6 Remodels Chromatin and Facilitates Reprogramming by Activating Gatad2b-Phosphorylation Dependent Heterochromatin Loosening

The authors identified mitogen-activated protein kinase kinase 6 as a chromatin relaxer and found that it could significantly enhance reprogramming.
[Cell Death & Differentiation]
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The Effects of Exosomes Derived from Trabecular Meshwork Cells on Schlemm’s Canal Endothelial Cells

To examine the interaction between trabecular meshwork cells on Schlemm’s canal endothelial cells, researchers investigated whether exosomes contributed to intercellular communication.
[Scientific Reports]
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Exacis Biotherapeutics Announces Strategic Partnership with CCRM for Specialty Manufacturing of Services and Investment for Development of iPSC-Derived mRNA-Engineered NK Cells

Exacis Biotherapeutics, Inc. announced initiation of a strategic partnership with Toronto-based Centre for Commercialization of Regenerative Medicine (CCRM) for specialty manufacturing services related to the development of Exacis’ innovative, iPSC-derived mRNA-engineered natural killer cell products to treat cancer.
[Exacis Biotherapeutics, Inc. (PR Newswire, Inc.)]
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G-CSF Secreted by Mutant IDH1 Glioma Stem Cells Abolishes Myeloid Cell Immunosuppression and Enhances the Efficacy of Immunotherapy

The authors showed that the efficacy of immune-stimulatory gene therapy was enhanced in isocitrate-dehydrogenase 1 (mIDH1) gliomas, due to the reprogramming of the myeloid cells’ compartment infiltrating the tumor microenvironment.
[Science Advances]
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High-Throughput Screening on Cochlear Organoids Identifies VEGFR-MEK-TGFB1 Signaling Promoting Hair Cell Reprogramming

Investigators established a robust, high-throughput cochlear organoid platform that facilitates 3D expansion of cochlear progenitor cells and differentiation of hair cells in a temporally regulated manner.
[Stem Cell Reports]
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Emerging Roles of Bromodomain Protein 4 in Regulation of Stem Cell Identity

The authors review the role of BRD4 in complex gene regulatory network during three specific states of stem cell transitions: cell differentiation, cell reprogramming and transdifferentiation.
[Stem Cells]
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Translational Models of 3-D Organoids and Cancer Stem Cells in Gastric Cancer Research

Investigators developed precise culture conditions for gastric organoids in vitro to improve the accuracy of the generation of organoid models for therapeutic and medical applications.
[Stem Cell Research & Therapy]
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Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming

The chromatin accessibility and transcriptional level of human ESCs and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing and RNA sequencing RNA-seq to identify potential reprogramming factors.
[Stem Cell Reviews and Reports]
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NaV1.5 Knockout in iPSCs: A Novel Approach to Study NaV1.5 Variants in a Human Cardiomyocyte Environment

Scientists developed a homozygous NaV1.5 KO iPSC line able to differentiate into cardiomyocytes with CRISPR/Cas9 tool. The NaV1.5 KO iPSC-cardiomyocytes exhibited an organized contractile apparatus, spontaneous contractile activity, and electrophysiological recordings confirmed the major reduction in total Na+ currents.
[Scientific Reports]
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Restoring Mammary Gland Structures and Functions with Autogenous Cell Therapy

In vitro chemical induction with RepSox generated chemically induced mammary epithelial cells (CiMECs) with milk secreting functions from goat ear fibroblasts (GEFs). Single-cell RNA sequencing revealed that during the reprogramming process, GEFs may have sequentially undergone embryonic ectoderm-like and different MEC developmental states.
[Biomaterials]
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Chromatin lncRNA Platr10 Controls Stem Cell Pluripotency by Coordinating an Intrachromosomal Regulatory Network

Scientists used a novel chromatin RNA in situ reverse transcription sequencing approach to profile long noncoding RNAs in the Oct4 promoter.
[Genome Biology]
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