Following the establishment of an inducible Dux transgenic mouse model, investigators demonstrated that transient overexpression of Dux not only improves somatic cell nuclear transfer efficiency but also increased that of chemically induced pluripotent stem cell reprogramming.
The authors summarize the latest advances in the understanding of PI3K/AKT/SOX2-driven stemness and its intertwined relations to p53-signaling in DNA damage response under conditions of pluripotency, reprogramming, and transformation.
Schaefer, T., Steiner, R., & Lengerke, C. (2020). SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer. International Journal of Molecular Sciences, 21(14), 4902. https://doi.org/10.3390/ijms21144902Cite