Transient Dux Expression Facilitates Nuclear Transfer and Induced Pluripotent Stem Cell Reprogramming

Following the establishment of an inducible Dux transgenic mouse model, investigators demonstrated that transient overexpression of Dux not only improves somatic cell nuclear transfer efficiency but also increased that of chemically induced pluripotent stem cell reprogramming.
[EMBO Reports]
Yang, L., Liu, X., Song, L., Di, A., Su, G., Bai, C., Wei, Z., & Li, G. (2020). Transient Dux expression facilitates nuclear transfer and induced pluripotent stem cell reprogramming. EMBO Reports, n/a(n/a), e202050054. https://doi.org/10.15252/embr.202050054 Cite
AbstractGraphical Abstract

Continue reading “Transient Dux Expression Facilitates Nuclear Transfer and Induced Pluripotent Stem Cell Reprogramming”

Bookmark

No account yet? Register

0
Share

SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer

The authors summarize the latest advances in the understanding of PI3K/AKT/SOX2-driven stemness and its intertwined relations to p53-signaling in DNA damage response under conditions of pluripotency, reprogramming, and transformation.
[International Journal of Molecular Sciences]
Schaefer, T., Steiner, R., & Lengerke, C. (2020). SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer. International Journal of Molecular Sciences, 21(14), 4902. https://doi.org/10.3390/ijms21144902 Cite
Full Article

Continue reading “SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer”

Bookmark

No account yet? Register

0
Share

Rad50 Mediates DNA Demethylation to Establish Pluripotent Reprogramming

Researchers found that Rad50 was highly expressed in pluripotent stem cells and that Rad50 regulated global DNA demethylation levels.
[Experimental and Molecular Medicine]
Park, H., Cho, B., & Kim, J. (2020). Rad50 mediates DNA demethylation to establish pluripotent reprogramming. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-020-0467-0 Cite
Full Article

Continue reading “Rad50 Mediates DNA Demethylation to Establish Pluripotent Reprogramming”

Bookmark

No account yet? Register

0
Share
Share