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cell reprogramming

NaV1.5 Knockout in iPSCs: A Novel Approach to Study NaV1.5 Variants in a Human Cardiomyocyte Environment

[Biophysical Journal] Scientists developed a homozygous NaV1.5 KO iPSC line able to differentiate into cardiomyocytes (iPSC-CMs) with CRISPR/Cas9 tool. The NaV1.5 KO iPSC-CMs exhibited an organized contractile apparatus, spontaneous contractile activity, and electrophysiological recordings confirmed the major reduction in total Na+ currents.

Inducing Somatic Cells into Pluripotent Stem Cells Is an Important Platform to Study the Mechanism of Early Embryonic Development

[Molecular Reproduction and Development] Scientists introduce the research advance of both somatic cell reprogramming and early embryonic development, indicating that the mechanisms of iPSCs also shares common features with that of early embryonic development in several aspects.

Lyell Immunopharma Announces FDA Clearance of IND for LYL132, a T-cell Receptor Therapy for Solid Tumors Being Developed in Collaboration with GSK

[Lyell Immunopharma, Inc. (Globenewswire, Inc.)] Lyell Immunopharma, Inc. announced that US FDA has cleared an Investigational New Drug (IND) application to initiate a Phase I clinical trial for LYL132, an investigational T-cell receptor therapy for patients with solid tumors expressing New York esophageal squamous cell carcinoma 1 that the company is developing in collaboration with GSK.

Lyell Immunopharma Announces FDA Clearance of IND for LYL132, a T-cell Receptor Therapy for Solid Tumors Being Developed in Collaboration with GSK

[Lyell Immunopharma, Inc.] Lyell Immunopharma, Inc. announced that the US FDA has cleared an Investigational New Drug (IND) application to initiate a Phase I clinical trial for LYL132, an investigational T-cell receptor therapy for patients with solid tumors expressing New York esophageal squamous cell carcinoma 1 that the company is developing in collaboration with GSK.

MAP2K6 Remodels Chromatin and Facilitates Reprogramming by Activating Gatad2b-Phosphorylation Dependent Heterochromatin Loosening

[Cell Death & Differentiation] The authors identified mitogen-activated protein kinase kinase 6 as a chromatin relaxer and found that it could significantly enhance reprogramming.

The Effects of Exosomes Derived from Trabecular Meshwork Cells on Schlemm’s Canal Endothelial Cells

[Scientific Reports] To examine the interaction between trabecular meshwork cells on Schlemm’s canal endothelial cells, researchers investigated whether exosomes contributed to intercellular communication.

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