cell transplantation

[Experimental & Molecular Medicine] The authors describe strategies for establishing primary hepatocyte organoids derived from either adult or fetal liver based on insights from signaling pathways regulating hepatocyte renewal in vivo.

[Blood Advances] 43 patients received hematopoietic stem cell transplantation (HSCT) in first remission including 38 patients receiving protocol-specified HSCT with conditioning consisting of individualized targeted doses of busulfan, etoposide, and cyclophosphamide. Three-year event-free survival of 56.8% and overall survival of 80.2% were accomplished.

[Journal of Experimental & Clinical Cancer Research] Alloantigen-activated CD4+ T cells were generated from CD4+ T cells isolated from BALB/c mice in cultures with dendritic cells induced from C57BL/6 mice.

[Bone Marrow Transplantation] Investigators reported on all 17 patients with BPDCN who underwent allogeneic hematopoietic cell transplantation (allo-HCT) at their center between 2000 and 2020, and concluded that allo-HCT provided long-lasting remissions in BPDCN patients, particularly when performed in complete remission.

[Communications Biology] Scientists showed the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T cells in actual recipients according to the cytomegalovirus reactivation pattern.

[Leukemia & Lymphoma] Investigators retrospectively analyzed 55 patients who underwent allogeneic stem cell transplantation for mantle cell lymphoma relapsed or refractory after rituximab and high-dose cytarabine within the MANTLE-FIRST project.