cell transplantation

[International Journal of Molecular Sciences] Researchers report on the development of an enhanced synergistic combination therapy comprising polyacetal–curcumin nanoconjugate and neural stem cells derived from induced pluripotent stem cells + mesenchymal stem cells treatment as a treatment option for severe sub-acute traumatic spinal cord injury.

[Heartseed, Inc.] Heartseed Inc. and Novo Nordisk A/S announced that they have entered into a collaboration and licence agreement for the development, manufacturing and commercialisation of Heartseed’s asset HS-001, an investigational cell therapy using purified cardiomyocytes derived from induced pluripotent stem cells, which is currently under development by Heartseed for the treatment of heart failure.

[Cell Proliferation] The authors summarize the role of CXCR4 in progression and treatment of acute leukemia, and discuss the potential value of using CXCR4 antagonists as immunosensitizer for graft-vs-leukemia effects of allogeneic HSC transplantation.

[Leukemia] The authors reported on 382 COVID-19 patients having undergone allogeneic or autologous hematopoietic cell transplantation reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH).

[Haematologica] Scientists identified a serial of genes including NEK2, RARα2, which induced multiple myeloma (MM) proliferation and drug-resistance resulting in MM relapse and poor outcome.

[British Journal of Haematology] Scientists explored the feasibility of generating bivalent-Leuk-STs directed against Wilms tumor 1 and preferentially expressed antigen in melanoma from umbilical cord blood units disqualified for allogeneic hematopoietic stem cell transplantation.