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cell transplantation

GlycoMimetics Announces Investigator-Sponsored Phase II Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation

[GlycoMimetics, Inc.] GlycoMimetics, Inc. announced that clinicians at Washington University School of Medicine in St. Louis have dosed the first patient in an investigator-sponsored trial evaluating uproleselan as a prophylactic agent to reduce gastrointestinal toxicities associated with high-dose melphalan in autologous hematopoietic cell transplantation for multiple myeloma.

Prolonged Suppression of Butyrate Producing Bacteria Is Associated with Acute Gastrointestinal Graft-versus-Host Disease and Transplant Related Mortality after Allogeneic Stem Cell Transplantation

[Clinical infectious Diseases] Scientists examined the abundance and butyrogenic capacity of butyrate producing bacteria in 28 healthy donors and 201 patients after allogeneic stem cell transplantation.

Allogeneic Hematopoietic Cell Transplantation for Myelofibrosis: Proposed Definitions and Management Strategies for Graft Failure, Poor Graft Function and Relapse: Best Practice Recommendations of the...

[Leukemia] A systematic approach to molecular monitoring, histopathological assessment and chimerism testing is proposed. These proposed recommendations aim to increase the accuracy and uniformity of reporting and to thereby facilitate the development of more consistent approaches.

Low-Dose Antithymocyte Globulin plus Low-Dose Posttransplant Cyclophosphamide Combined with Cyclosporine and Mycophenolate Mofetil for Prevention of Graft-versus-Host Disease after HLA-Matched Unrelated Donor Peripheral Blood...

[Bone Marrow Transplantation] To improve the efficiency of graft-versus-host disease (GvHD) prophylaxis in matched unrelated donor peripheral blood stem cell transplantation, 51 patients with hematological malignancies received a novel regimen for GvHD prophylaxis composed of low dose antithymocyte globulin.

Impact of Prior JAK-Inhibitor Therapy with Ruxolitinib on Outcome after Allogeneic Hematopoietic Stem Cell Transplantation for Myelofibrosis: A Study of the CMWP of EBMT

[Leukemia] The authors studied the impact of pretreatment with JAK1/2 inhibitor ruxolitinib on patient outcome after allogeneic hematopoietic stem cell transplantation.

Osteopontin and Transplantation: Where Are We Now?

[Archivum Immunologiae Et therapiae Experimentalis] The authors summarize recent advances in knowledge about osteopontin function in the kidney, heart, liver, lung, and hematopoietic stem cell transplantation.

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