cell transplantation

[Science Translational Medicine] Reduced-intensity conditioning for HLA-haploidentical hematopoietic cell transplantation was augmented with same-donor memory-like natural killer (NK) cells on day +7 and 3 weeks of N-803 to treat patients with relapsed/refractory AML in a clinical trial.

[Bone Marrow Transplantation] Scientists investigated whether gilteritinib, a selective FLT3 inhibitor, could enhance graft-versus-leukemia effects against FLT3 internal tandem duplication mutant transfected Ba/F3 leukemia in mice.

[Molecular Therapy] Investigators treated three children suffering from severe, therapy-refractory GvHD with polyclonally expanded regulatory T cells generated from the original stem cell donor.

[Bone Marrow Transplantation] The authors evaluated the prevalence of key vascular complications and graft-versus-host disease among 122 pediatric patients with an allogeneic hematopoietic stem cell transplantation between 2001 and 2013.

[Bone Marrow Transplantation] Investigators studied the relationship between human cytomegalovirus reactivation and adaptive NK cells in 70 patients monitored weekly until 100 days after hematopoietic stem cell transplantation

[Haematologica] Researchers designed a CD34/CD3 bispecific T-cell engager (BiTE) and characterized its anti-leukemia potential in vitro, ex vivo and in vivo.