cell transplantation

[Xenotransplantation] Human MSCs derived from umbilical cord tissue were transdifferentiated into hepatocyte-like cells using patient-derived serum along with dimethyl sulfoxide.

[Haematologica] Investigators evaluated the response to inotuzumab ozogamicin in 31 relapsed/refractory B cell acute lymphoblastic leukemia patients with extramedullary disease.

[Lancet Haematology] Scientists reported the results of a prospective, single-arm, Phase II clinical trial done at the University Medical Center Utrecht and the Princess Máxima Center for Pediatric Oncology to investigate individualized dosing of anti-thymocyte globulin for unrelated allogeneic HSC transplantation in pediatric patients.

[American Journal of Hematology] A single-arm exploratory clinical trial is the first to evaluate the safety and efficacy of sequential anti-CD19 and anti-BCMA CAR-T cell infusion, followed by lenalidomide maintenance after autologous stem-cell transplantation in ten high-risk newly diagnosed multiple myeloma patients.

[NorthSea Therapeutics B.V.] NorthSea Therapeutics B.V. announced it has initiated a Phase I study with SEFA-6179 in adult subjects, targeting the initial orphan indication of the treatment of intestinal failure associated liver disease.

[Haematologica] Dendritic cells were either generated from monocytes or isolated directly from blood of healthy donors or graft-versus-host disease patients and co-cultured in a mixed lymphocyte reaction with T cells obtained from healthy donors or transplantation bags.