LIM Domain Proteins Pinch1/2 Regulate Chondrogenesis and Bone Mass in Mice

The authors report that deleting Pinch1 in limb MSCs and Pinch2 globally (double knockout) in mice caused severe chondrodysplasia, while single mutant mice did not display marked defects.
[Bone Research]
Lei, Y., Fu, X., Li, P., Lin, S., Yan, Q., Lai, Y., Liu, X., Wang, Y., Bai, X., Liu, C., Chen, D., Zou, X., Cao, X., Cao, H., & Xiao, G. (2020). LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice. Bone Research, 8(1), 1–13. https://doi.org/10.1038/s41413-020-00108-y Cite
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Mesenchymal Stem Cell Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via miR-31-5p/ATF6 axis

Researchers investigated the role of MSC-exosomes on endplate chondrocytes with a tert-butyl hydroperoxide-induced oxidative stress cell model and an intervertebral disc degeneration rat model.
[Molecular Therapy-Nucleic Acids]
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Roles of Fibrinolytic Factors in the Alterations in Bone Marrow Hematopoietic Stem/Progenitor Cells during Bone Repair

Osteoblasts, osteoclasts, chondrocytes, and macrophages involved in the bone repair process originate from hematopoietic stem/progenitor cells and mesenchymal stem cells in the bone marrow.
[Inflammation and Regeneration]
Okada, K., Nishioka, M., & Kaji, H. (2020). Roles of fibrinolytic factors in the alterations in bone marrow hematopoietic stem/progenitor cells during bone repair. Inflammation and Regeneration, 40(1), 22. https://doi.org/10.1186/s41232-020-00128-5 Cite
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Shaking Culture Enhances Chondrogenic Differentiation of Mouse Induced Pluripotent Stem Cell Constructs

Scientists suggest that shaking culture activated TGF-β expression and Wnt signaling to promote chondrogenic differentiation in mouse iPSCs in vitro.
[Scientific Reports]
Limraksasin, P., Kosaka, Y., Zhang, M., Horie, N., Kondo, T., Okawa, H., Yamada, M., & Egusa, H. (2020). Shaking culture enhances chondrogenic differentiation of mouse induced pluripotent stem cell constructs. Scientific Reports, 10(1), 14996. https://doi.org/10.1038/s41598-020-72038-y Cite
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Chitinase-3 Like-Protein-1 Function and Its Role in Diseases

Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) binds to chitin, heparin, and hyaluronic acid, and is regulated by ECM changes, cytokines, growth factors, drugs, and stress. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.
[Signal Transduction and Targeted Therapy]
Zhao, T., Su, Z., Li, Y., Zhang, X., & You, Q. (2020). Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduction and Targeted Therapy, 5(1), 1–20. https://doi.org/10.1038/s41392-020-00303-7 Cite
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RASL11B Gene Enhances Hyaluronic Acid-Mediated Chondrogenic Differentiation in Human Amniotic Mesenchymal Stem Cells via the Activation of Sox9/ERK/Smad Signals

Investigators aimed to elucidate the molecular mechanisms, whereby hyaluronic acid, a main ECM component of articular cartilage, promoted the chondrogenic differentiation of human amniotic mesenchymal stem cells.
[Experimental Biology and Medicine]
Luo, Y., Wang, A.-T., Zhang, Q.-F., Liu, R.-M., & Xiao, J.-H. (2020). RASL11B gene enhances hyaluronic acid-mediated chondrogenic differentiation in human amniotic mesenchymal stem cells via the activation of Sox9/ERK/smad signals: Experimental Biology and Medicine. https://doi.org/10.1177/1535370220944375 Cite
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Bidirectional Wnt Signaling between Endoderm and Mesoderm Confers Tracheal Identity in Mouse and Human Cells

Investigators showed that canonical Wnt signaling in mesoderm was critical to confer trachea mesenchymal identity in human and mouse.
[Nature Communications]
Kishimoto, K., Furukawa, K. T., Luz-Madrigal, A., Yamaoka, A., Matsuoka, C., Habu, M., Alev, C., Zorn, A. M., & Morimoto, M. (2020). Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells. Nature Communications, 11(1), 4159. https://doi.org/10.1038/s41467-020-17969-w Cite
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Inhibition of Axin1 in Osteoblast Precursor Cells Leads to Defects in Postnatal Bone Growth through Suppressing Osteoclast Formation

Osteoclast formation in primary bone marrow derived microphage (BMM) cells was significantly decreased when BMM cells were cultured with conditioned media (CM) collected from osteoblasts derived from Axin1Osx mice compared with BMM cells cultured with CM derived from WT mice.
[Bone Research]
Shu, B., Zhao, Y., Zhao, S., Pan, H., Xie, R., Yi, D., Lu, K., Yang, J., Xue, C., Huang, J., Wang, J., Zhao, D., Xiao, G., Wang, Y., & Chen, D. (2020). Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation. Bone Research, 8(1), 1–8. https://doi.org/10.1038/s41413-020-0104-5 Cite
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Subarachnoid Transplantation of Human Umbilical Cord Mesenchymal Stem Cell in Rodent Model with Subacute Incomplete Spinal Cord Injury: Preclinical Safety and Efficacy Study

The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
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Precision Installation of a Highly Efficient Suicide Gene Safety Switch in Human Induced Pluripotent Stem Cells

Investigators report that the commonly used EF1α promoter was silenced in induced pluripotent stem cells, and that the endogenous promoter of the PPP1R12C gene was not strong enough to drive high levels of inducible caspase‐9 expression.
[Stem Cells Translational Medicine]
Shi, Z.-D., Tchao, J., Wu, L., & Carman, A. J. (n.d.). Precision installation of a highly efficient suicide gene safety switch in human induced pluripotent stem cells. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0007 Cite
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Regenerative Effects of Human Chondrocyte Sheets in a Xenogeneic Transplantation Model Using Immune‐Deficient Rats

Researchers investigated the regenerative effects of human chondrocyte sheets on articular cartilage in a xenogeneic transplantation model using immune‐deficient rats.
[Journal of Tissue Engineering and Regenerative Medicine]
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