[Molecular Therapy-Nucleic Acids] MiR-378 amplified osteoarthritis (OA) development via repressing chondrocyte autophagy and by inhibiting bone marrow MSC chondrogenesis, thus indicating miR-378 may be a potential therapeutic target for OA treatments.
[International Journal of Oral Science] Scientists elucidated a new path in cytoskeleton re-organization in chondrocytes in response to changed substrate stiffnesses by characterizing the axis shift from the secreted extracellular protein laminin β1, focal adhesion complex protein FAK to microfilament bundling.
[Journal of Nanobiotechnology] Scientists found that curcumin primed adipose tissue-derived MSCs-derived small extracellular vesicles (ADMSCs-sEVs) exhibited an enhanced protective effect compared with free curcumin and ADMSCs-sEV in TBHP-induced chondrocytes.
[Cell Discovery] Scientists found that the expression of EP4 was largely increased in the injured articular cartilage in both humans and mice. Knocking out EP4 in cartilage enhanced stable mature articular cartilage formation instead of fibrocartilage, and reduced joint pain.
[Journal of Bone and Mineral Research] Scientists provide a comprehensive overview of the different iPSCs to chondrocytes differentiation approaches, the hitherto described iPSC-chondrocyte disease models and mechanistic and/or therapeutic insights that have been derived from their investigation.
[Cell Death & Disease] Investigators found that inhibition of G protein-coupled receptor 4 (GPR4) with the antagonist NE52-QQ57 ameliorated osteoarthritis progression in mice, promoted ECM production, and protected cartilage from degradation in human articular cartilage explants.