Mesenchymal Stromal Cell-Derived Septoclasts Resorb Cartilage during Developmental Ossification and Fracture Healing

Scientists showed that matrix degradation and chondrocyte phagocytosis were mediated by fatty acid binding protein 5-expressing cells representing septoclasts, which had a mesenchymal origin and were not derived from hematopoietic cells.
[Nature Communications]
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Augmented ERAD (ER-Associated Degradation) Activity in Chondrocytes Is Necessary for Cartilage Development and Maintenance

Scientists examined the necessity of the ERAD complex in chondrocytes for cartilage formation and maintenance.
[Science Advances]
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Exercise-Induced Piezoelectric Stimulation for Cartilage Regeneration in Rabbits

Scientists demonstrated that a biodegradable piezoelectric poly(L-lactic acid) nanofiber scaffold under applied force or joint load could act as a battery-less electrical stimulator to promote chondrogenesis and cartilage regeneration.
[Science Translational Medicine]
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Evaluating Initial Integration of Cell-Based Chondrogenic Constructs in Human Osteochondral Explants

Investigators examined whether integration of allogeneic cell-based implants with the surrounding native cartilage could be demonstrated in an ex vivo human osteochondral culture model.
[Tissue Engineering Part C-Methods]
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PPARα−ACOT12 Axis Is Responsible for Maintaining Cartilage Homeostasis through Modulating De Novo Lipogenesis

In Ppara−/− mice, the authors found that an increased DNL stimulated the cartilage degradation and identified ACOT12 as a key regulatory factor.
[Nature Communications]
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Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair

A platelet lysate-rich plasma macroporous hydrogel scaffold with around 100 μm pore size and 1.25 MPa Young’s modulus was developed to sustainedly recruit and polarize endogenous anti-inflammatory macrophages for improving cartilage defect repair.
[Advanced Healthcare Materials]
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Migratory Chondroprogenitors Retain Superior Intrinsic Chondrogenic Potential for Regenerative Cartilage Repair as Compared to Human Fibronectin Derived Chondroprogenitors

Researchers compared human fibronectin adhesion assay-derived chondroprogenitors with migratory chondroprogenitors in normoxic and hypoxic culture conditions, investigating their growth characteristics, surface marker profile and trilineage potency.
[Scientific Reports]
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Human Platelet Lysate (hPL) Alters the Lineage Commitment and Paracrine Functions of Human Mesenchymal Stem Cells via Mitochondrial Metabolism

Scientists showed that MSCs cultured in hPL displayed a reduced cell size and cell spreading, but an improved proliferation and osteogenic capability compared with cells maintained in fetal bovine serum.
[Applied Materials Today]
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Cartilaginous Extracellular Matrix Enriched with Human Gingival Mesenchymal Stem Cells Derived “Matrix Bound Extracellular Vesicles” Enabled Functional Reconstruction of Tracheal Defect

Coculturing chondrocytes with MSCs derived from gingival lamina propria produced abundant “matrix bound gingival MSC derived extracellular vesicles” in forming cartilaginous extracellular matrix (ECM), which were further preserved in acellular cartilaginous ECM following mild, short-period decellularization.
[Advanced Science]
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Long-Term Repair of Porcine Articular Cartilage Using Cryopreservable, Clinically Compatible Human Embryonic Stem Cell-Derived Chondrocytes

Investigators described the development, transcriptomic ontogenetic characterization and quality assessment at the single cell level, as well as the scaled manufacturing of an allogeneic human PSC-derived articular chondrocyte formulation that exhibited long-term functional repair of porcine articular cartilage.
[NPJ Regenerative Medicine]
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Loss of Mutual Protection between Human Osteoclasts and Chondrocytes in Damaged Joints Initiates Osteoclast-Mediated Cartilage Degradation by MMPs

Researchers suggested that bone-resident osteoclasts and chondrocytes exerted mutually protective effects on their ‘native’ tissue. However, when osteoclasts contacted non-native cartilage, they caused degradation via matrix metalloproteinases (MMPs).
[Scientific Reports]
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