Inhibition of Axin1 in Osteoblast Precursor Cells Leads to Defects in Postnatal Bone Growth through Suppressing Osteoclast Formation

Osteoclast formation in primary bone marrow derived microphage (BMM) cells was significantly decreased when BMM cells were cultured with conditioned media (CM) collected from osteoblasts derived from Axin1Osx mice compared with BMM cells cultured with CM derived from WT mice.
[Bone Research]
Shu, B., Zhao, Y., Zhao, S., Pan, H., Xie, R., Yi, D., Lu, K., Yang, J., Xue, C., Huang, J., Wang, J., Zhao, D., Xiao, G., Wang, Y., & Chen, D. (2020). Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation. Bone Research, 8(1), 1–8. https://doi.org/10.1038/s41413-020-0104-5 Cite
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Subarachnoid Transplantation of Human Umbilical Cord Mesenchymal Stem Cell in Rodent Model with Subacute Incomplete Spinal Cord Injury: Preclinical Safety and Efficacy Study

The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
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Precision Installation of a Highly Efficient Suicide Gene Safety Switch in Human Induced Pluripotent Stem Cells

Investigators report that the commonly used EF1α promoter was silenced in induced pluripotent stem cells, and that the endogenous promoter of the PPP1R12C gene was not strong enough to drive high levels of inducible caspase‐9 expression.
[Stem Cells Translational Medicine]
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Regenerative Effects of Human Chondrocyte Sheets in a Xenogeneic Transplantation Model Using Immune‐Deficient Rats

Researchers investigated the regenerative effects of human chondrocyte sheets on articular cartilage in a xenogeneic transplantation model using immune‐deficient rats.
[Journal of Tissue Engineering and Regenerative Medicine]
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