A Chondrosphere-Based Scaffold Free Approach to Manufacture an In Vitro Articular Cartilage Model

Human articular chondrocytes and immortalised mesenchymal cells differentiated in chondrocytes were cultured in round-bottom 96-well plates to produce multicellular spheroids and their growth kinetics and viability was evaluated over seven days of culture.
[Tissue Engineering Part A]
Scalzone, A., Wang, X. N., Dalgarno, K., Ferreira-Duarte, A. M., & Gentile, P. (2021). A chondrosphere-based scaffold free approach to manufacture an in-vitro articular cartilage model. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2021.0061 Cite
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Cartilage Tissue miR-214-3p Regulates the TrkB/ShcB Pathway Paracrine VEGF to Promote Endothelial Cell Migration and Angiogenesis

The authors explored the mechanisms through which chondrocytes regulated endothelial cell migration and angiogenesis in Osteoarthritis.
[Bone]
Xiao, P., Zhu, X., Sun, J., Zhang, Y., Qiu, W., Li, J., & Wu, X. (2021). Cartilage tissue miR-214-3p regulates the TrkB/ShcB pathway paracrine VEGF to promote endothelial cell migration and angiogenesis. Bone, 116034. https://doi.org/10.1016/j.bone.2021.116034 Cite
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H3K36 Methyltransferase NSD1 Regulates Chondrocyte Differentiation for Skeletal Development and Fracture Repair

Investigators showed that mice with Nsd1 deficiency in Prx1+ mesenchymal progenitors but not in Col2+ chondrocytes showed impaired skeletal growth and fracture healing accompanied by decreased chondrogenic differentiation.
[Bone Research]
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Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage

Researchers demonstrated that systemic transplantation of adult multipotent muscle-derived stem/progenitor cells- isolated from young mice-rejuvenates the knee articular cartilage of naturally aged mice.
[Aging and Disease]
Seth D. Thompson, R. P., & Seth D. Thompson, R. P. (2021). Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage. Aging and Disease, 12(3), 726–731. https://doi.org/10.14336/AD.2020.1118 Cite
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MFG-E8 Regulated by miR-99b-5p Protects against Osteoarthritis by Targeting Chondrocyte Senescence and Macrophage Reprogramming via the NF-κB Pathway

The authors identified milk fat globule-epidermal growth factor 8 (MFG-E8) as a key factor mediating chondrocyte senescence and macrophage polarization and revealed its role in the pathology of osteoarthritis.
[Cell Death & Disease]
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Wnt/ß-Catenin-Mediated p53 Suppression Is Indispensable for Osteogenesis of Mesenchymal Progenitor Cells

Using conditional lineage-tracing mice, scientists demonstrated that chondrocytes gave rise to a sizable fraction of mesenchymal progenitor cells, which served as progenitors of chondrocyte-derived osteoblasts.
[Cell Death & Disease]
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Comparative Evaluation of Isogenic Mesodermal and Ectomesodermal Chondrocytes from Human iPSCs for Cartilage Regeneration

Investigators differentiated human induced pluripotent stem cells into the mesodermal and ectomesodermal lineages to prepare isogenic mesodermal cell–derived chondrocytes and neural crest cell–derived chondrocytes for comparative evaluation.
[Science Advances]
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The Effects of Locomotion on Bone Marrow Mesenchymal Stem Cell Fate: Insight Into Mechanical Regulation and Bone Formation

Scientists summarize the regulatory effects of locomotion/mechanical loading on bone marrow MSCs activities.
[Cell and Bioscience]
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High Glucose Suppresses Autophagy through the AMPK Pathway While It Induces Autophagy via Oxidative Stress in Chondrocytes

The authors revealed that high glucose could induce apoptosis and senescence in chondrocytes, in addition to regulating autophagy dynamically.
[Cell Death & Disease]
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Kartogenin Prevents Cartilage Degradation and Alleviates Osteoarthritis Progression in Mice via the miR-146a/NRF2 Axis

Scientists explored the protective effects and underlying mechanisms of kartogenin on articular cartilage degradation using mice with post-traumatic osteoarthritis .
[Cell Death & Disease]
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Specific MicroRNAs Found in Extracellular Matrix Vesicles Regulate Proliferation and Differentiation in Growth Plate Chondrocytes

Investigators selected a subset of enriched microRNAs and transfected synthetic mimics back into resting zone and growth zone cells. Transfecting growth plate chondrocytes with select microRNA produced a broad range of phenotypic responses indicating that matrix vesicle-based microRNAs were involved in the regulation of these cells.
[Calcified Tissue International]
Specific MicroRNAs Found in Extracellular Matrix Vesicles Regulate Proliferation and Differentiation in Growth Plate Chondrocytes | SpringerLink. (n.d.). Retrieved May 6, 2021, from https://link.springer.com/article/10.1007%2Fs00223-021-00855-y Cite
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