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chondrocytes

FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

[Cancer Research] Scientists studied proton radiotherapy (PRT) damage to skin and mesenchymal tissues of muscle and bone and found that flash PRT of the C57BL/6 murine hind leg produced fewer severe toxicities leading to death or requiring euthanasia than standard proton-PRT of the same dose.

Extracellular Vesicles Derived from LPS-Preconditioned Human Synovial Mesenchymal Stem Cells Inhibit Extracellular Matrix Degradation and Prevent Osteoarthritis of the Knee in a Mouse Model

[Stem Cell Research & Therapy] Researchers explored effects of lipopolysaccharide (LPS)-pre extracellular vesicles (EVs) on chondrocyte proliferation, migration, and chondrocyte apoptosis, as well as the protective effect of LPS-pre EVs on mouse articular cartilage.

Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model

[Cartilage] Investigators evaluated the effects of MSC-extracellular vesicles on chondrocyte proliferation in vitro and on cartilage repair in vivo following bone marrow stimulation of focal chondral defects of the knee.

Adenosine Deaminase Modulates Metabolic Remodeling and Orchestrates Joint Destruction in Rheumatoid Arthritis

[Scientific Reports] Scientists presented an integrative analysis of clinical data, cytokines, serum metabolomics in rheumatoid arthritis patients and mechanistic studies on adenosine deaminase-mediated effects on in vitro cell culture models.

Vascularization of Tissue Engineered Cartilage – Sequential In Vivo MRI Display Functional Blood Circulation

[Biomaterials] Scientists investigated whether a gridded three-dimensional (3D) bioprinted construct would allow ingrowth of blood vessels and thus prove a functional concept for vascularization of bioengineered tissue.

Comparison of Mesenchymal Stromal Cells from Peritoneal Dialysis Effluent with Those from Umbilical Cords: Characteristics and Therapeutic Effects on Chronic Peritoneal Dialysis in Uremic...

[Stem Cell Research & Therapy] Researchers compared the cytoprotection between peritoneal dialysis (PD) effluent-derived MSCs and umbilical cord-derived MSCs in the treatment of both peritoneal membrane and kidney injury in uremic rats with chronic PD.

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