chondrocytes

[NPJ Regenerative Medicine] Extracellular vesicles derived from human articular chondrocytes cultured under differentiation medium or from chondrogenically committed human bone marrow mesenchymal stem cells induced a chondrogenic phenotype characterized by marked induction of SOX9, COMP, Aggrecan and Collagen type II, and matrix glycosaminoglycans synthesis.

[Cellular and Molecular Life Sciences] Scientists present current achievements in the development of small molecular drugs for cartilage regeneration, particularly in the fields of chondrocyte generation and reversion of chondrocyte degenerative phenotypes.

[Cartilage] Researchers implanted the autologous chondrocyte constructs into full-thickness chondral defects in the femoral condyle, compared those results with empty and acellular scaffold controls, and compared implantation techniques with adhesive alone and with partial adhesive with suture.

[Science Advances] Researchers aimed to identify the causal pathogenic mutation in an early-onset osteoarthritis family, followed by functional studies in human iPSCs in an in vitro organoid cartilage model.

[Stem Cells International] The authors evaluated the capability of human umbilical cord mesenchymal stromal cells mixed with hyaluronan to treat osteoarthritis in a rabbit model.

[Scientific Reports] Investigators established and verified an in vitro experimental system for the direct co-culture of cell pellets prepared from mouse auricular chondrocytes and macrophages polarized into four phenotypes.