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chondrocytes

Rutin Inhibited the Advanced Glycation End Products-Stimulated Inflammatory Response and Extracellular Matrix Degeneration via Targeting TRAF-6 and BCL-2 Proteins in Mouse Model of Osteoarthritis

[Aging] Scientists screened rutin (RT) for its activity against osteoarthritis with in vivo and in vitro models of osteoarthritis. Pretreatment of RT decreased the ECM degradation, inhibited expression of TRAF-6 and BCL-2 the NF-κB/MAPK pathway proteins.

Doxorubicin Suppresses Chondrocyte Differentiation by Stimulating ROS Production

[European Journal of Pharmaceutical Sciences] Scientists explored the specific mechanism of doxorubicin in osteoarthritis (OA). A mouse OA model was established by destabilizing the medial meniscus, and the role of DOX was determined by intraperitoneally injecting five or ten mg/kg DOX.

SPRY4 Acts as an Indicator of Osteoarthritis Severity and Regulates Chondrocyte Hypertrophy and ECM Protease Expression

[NPJ Regenerative Medicine] Using SPRY4 gene delivery into healthy and degenerated chondrocytes, investigators elucidated the role of SPRY4 in preventing chondrocyte hypertrophy. In addition to using the human cartilage tissues with the destabilization of the model in Sprague-Dawley rats, the role of SPRY4 in cartilage tissues and chondrocytes was explored through their molecular and histological analysis.

The Chondrogenic Potential of First-Trimester and Term Placental Mesenchymal Stem/Stromal Cells

[Cartilage] MSCs were isolated from first-trimester and term placentae. BM-MSCs were commercially obtained. Chondrogenesis was induced by micromass culture in commercial chondrogenic media for 7, 14, or 21 days.

Long-Term Stability, High Strength, and 3D Printable Alginate Hydrogel for Cartilage Tissue Engineering Application

[Biomedical Materials] Researchers developed a double crosslinked alginate hydrogel for 3D bioprinting, and human umbilical cord MSCs could differentiate into chondrocytes on its printed 3D scaffold after four weeks' culture.

Tracing the Skeletal Progenitor Transition during Postnatal Bone Formation

[Cell Stem Cell] The authors showed that postnatal osteoblasts arose primarily from chondrocytes before adolescence and from Lepr+ bone marrow stromal cells after adolescence. Thus, short-term developmental skeletal progenitors generated the long-term adult skeletal progenitors.

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