chronic inflammation

[American Journal of Pathology] Poorly formed necrotic tuberculosis (TB) granulomas containing a high expression of Mycobacterium tuberculosis antigens were elevated in TB/HIV co-infected lymph nodes, and inducible nitric oxide synthase as well as Arg-1 expression was significantly higher in TB/HIV co-infected compared to HIV-negative TB or control tissues.

[Leonhardt Ventures (Globe Newswire, Inc.)] Leonhardt Ventures LLC announced that it has begun an active research program to combine its patent-pending klotho expression bioelectric stimulation technologies with newly acquired klotho expressing MSC technology.

[Scientific Reports] Scientists investigated whether chronic inflammation markers C-reactive protein and soluble urokinase-type plasminogen activator receptor (suPAR), as well plasma levels of five different cytokine-specific autoantibodies.

[Scientific Reports] In vitro and in vivo experiments showed that the expression of adiponectin was decreased and the expression of Il6 and Tnf was increased in the nerve-crushed group compared to that in the control group.

[PLoS Biology] Researchers performed single-cell RNA-sequencing of colon-derived stromal cells and identified distinct classes of fibroblasts with gene signatures that were differentially regulated by chronic inflammation, including IL-11–producing inflammatory fibroblasts.

[Nature Reviews Rheumatology] Investigators review the molecular mechanisms that limit the duration of immune responses in health and discuss the factors that alter such regulation in the setting of systemic lupus erythematosus and rheumatoid arthritis.