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chronic inflammation

Putative Regulation of Macrophage-Mediated Inflammation by Catestatin

[Trends in Immunology] Investigators hypothesize that macrophages produce catestatin in an inflammation-dependent manner and thereby might self-regulate inflammation in an autocrine fashion.

Association between Immunologic Markers and Cirrhosis in Individuals with Chronic Hepatitis B

[Scientific Reports] The authors sampled 175 hepatocellular carcinoma, 117 cirrhotic and 165 non-cirrhotic controls from a prospective cohort study of chronically hepatitis B virus-infected individuals to assess immunologic markers in relation to liver disease.

Signal-Transducing Adaptor Protein-1 and -2 in Hematopoiesis and Diseases

[Experimental Hematology] Recent findings have shown the critical roles of signal-transducing adaptor protein (STAP)-2 in B cell progenitor cells in marrow under hematopoietic stress and STAP-1 and -2 in BCR-ABL-transduced leukemogenesis. In this review, the authors focus on the role of STAPs in the bone marrow.

NAMPT-Derived NAD+ Fuels PARP1 to Promote Skin Inflammation through Parthanatos Cell Death

[PLoS Biology] Investigators reported that the genetic and pharmacological inhibition of nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in the salvage pathway of NAD+ biosynthesis, reduced oxidative stress and cell death in zebrafish models of chronic skin inflammation.

RvD1 Accelerates the Resolution of Inflammation by Promoting Apoptosis of the Recruited Macrophages via the ALX/FasL-FasR/Caspase-3 Signaling Pathway

[Cell Death Discovery] Mice were administered Resolvin D1 via the tail vein 3 and 4 days after stimulation with lipopolysaccharide.

Resolvin-D2 Targets Myogenic Cells and Improves Muscle Regeneration in Duchenne Muscular Dystrophy

[Nature Communications] Resolvin-D2 directly targeted myogenic cells and promoted their differentiation and the expansion of the pool of myogenic progenitor cells leading to increased myogenesis.

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