Tag results:

chronic kidney disease

A Novel Renal Perivascular Mesenchymal Cell Subset Gives Rise to Fibroblasts Distinct from Classic Myofibroblasts

[Scientific Reports] The authors described a novel subset of renal perivascular MSCs that expressed Meflin, a glycosylphosphatidylinositol-anchored protein that was recently identified as a marker of fibroblasts essential for cardiac tissue repair.

Irisin Protects against Vascular Calcification by Activating Autophagy and Inhibiting NLRP3-Mediated Vascular Smooth Muscle Cell Pyroptosis in Chronic Kidney Disease

[Cell Death & Disease] Irisin effectively inhibited β-GP-induced calcium deposition in VSMCs in vitro and in mice aortic rings ex vivo. Overexpression of Nlrp3 attenuated the suppressive effect of Irisin on VSMC calcification.

Bone Marrow Mesenchymal Stem Cell-Derived Exosomal microRNA-381-3p Alleviates Vascular Calcification in Chronic Kidney Disease by Targeting NFAT5

[Cell Death & Disease] The authors investigated the mechanism of bone marrow MSC-derived exosome using high phosphate stimulated human aortic smooth muscle cells and 5/6 subtotal nephrectomy rat models.

Blood-Brain Barrier and Gut Barrier Dysfunction in Chronic Kidney Disease with a Focus on Circulating Biomarkers and Tight Junction Proteins

[Scientific Reports] Researchers examined blood–brain barrier disruption, by assessing brain-derived neurotropic factor, neuron-specific enolase levels, and gut-blood barrier disruption by trimethylamine N-oxide in chronic kidney disease patients.

Endothelial Cells: Potential Novel Regulators of Renal Inflammation

[American Journal of Physiology-Renal Physiology] Scientists consider in-depth mechanisms of endothelial activation and the novel mechanism of endothelial antigen presentation.

Modeling Injury and Repair in Kidney Organoids Reveals That Homologous Recombination Governs Tubular Intrinsic Repair

[Science Translational Medicine] Single-nuclear RNA sequencing of kidney organoids after cisplatin exposure identified 159 differentially expressed genes and 29 signal pathways in tubular cells undergoing intrinsic repair.

Popular