This study analyzes the role of uremic toxins in sarcopenia at different stages of chronic kidney disease (CKD), evaluating changes in the muscular regeneration process. Cultured C2C12 cells were incubated with a combination of indoxyl sulphate and p-cresol at high doses or low doses resembling late or early CKD stages, respectively.
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Alcalde-Estévez, E., Sosa, P., Asenjo-Bueno, A., Plaza, P., Olmos, G., Naves-Díaz, M., Rodríguez-Puyol, D., López-Ongil, S., & Ruiz-Torres, M. P. (2021). Uraemic toxins impair skeletal muscle regeneration by inhibiting myoblast proliferation, reducing myogenic differentiation, and promoting muscular fibrosis. Scientific Reports, 11(1), 512. https://doi.org/10.1038/s41598-020-79186-1 Cite