Circulating tumor cells enumeration at initiation of endocrine therapy (ET), and at early and following time points was prognostic in ER-positive metastatic breast cancer starting second-line or later ET.
[npj Breast Cancer]
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Researchers showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast cancer stem cell expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.
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Scientists applied fluorescence in vivo flow cytometryto monitor circulating tumor cells noninvasively in an orthotopic mouse model of human prostate cancer.
[Light-Science & Applications]
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Investigators designed a systemic metastasis-targeted nanotherapeutic (H@CaPP) to hinder the multiple steps of tumor metastasis. H@CaPP efficiently inhibited tumor metastasis and prolonged overall survival of 4T1 mammary tumor-bearing mice.
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Researchers discuss the technologies for detection and enrichment of circulating tumor cells, as well as clinical applications involving circulating tumor cells.
Scientists discuss the technologies for detection and enrichment of circulating tumor cells, as well as clinical applications involving circulating tumor cells.
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Using quantitative real-time PCR, the authors evaluated the expression of EPCAM, MUC1, CEA, HE4 and CA125 mRNAs, as putative markers of circulating tumor cells, in the blood of 51 epithelial ovarian cancer patients before and/or after adjuvant chemotherapy.
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Scientists found that Bedaquiline had no effect on the growth of non-tumorigenic mammary epithelial cells or primary tumors in vivo.
[Cell Death & Differentiation]
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Fiorillo, M., Scatena, C., Naccarato, A. G., Sotgia, F., & Lisanti, M. P. (2021). Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase. Cell Death & Differentiation, 1–21. https://doi.org/10.1038/s41418-021-00788-x Cite
Through structure-activity relationship studies focused on the actin-binding tail region of MycB, scientists identified a potent truncated derivative that inhibits polymerization of G-actin and severs F-actin by binding to actin’s barbed end cleft.
[Journal of the American Chemical Society]
Investigators show the vast scope and application of microfluidic systems and how these systems will ensure advancements to future prostate cancer management.
[Urologic Oncology: Seminars and Original Investigations]
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Scientists used CanPatrol circulating tumor cells (CTC)-enrichment technique to detect CTCs from blood samples and classify subpopulations into epithelial, mesenchymal, and hybrids.
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Yang, J., Ma, J., Jin, Y., Cheng, S., Huang, S., Zhang, N., & Wang, Y. (2021). Development and validation for prognostic nomogram of epithelial ovarian cancer recurrence based on circulating tumor cells and epithelial–mesenchymal transition. Scientific Reports, 11(1), 6540. https://doi.org/10.1038/s41598-021-86122-4 Cite