Molecular Testing in Breast Cancer: Current Status and Future Directions

The authors provide an overview of currently available molecular assays and testing modalities that have prognostic, predictive, and therapeutic value. These include multi-gene assays for invasive breast cancer and ductal carcinoma in situ, and companion tests to detect PIK3CA mutations and NTRK fusions.
[Journal of Molecular Diagnostics]
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Role of Aneuploid Circulating Tumor Cells and CD31+ Circulating Tumor Endothelial Cells in Predicting and Monitoring Anti-angiogenic Therapy Efficacy in Advanced NSCLC

Co-detection and comprehensive phenotypic and karyotypic molecular characterization of aneuploid circulating tumor cells and circulating tumor endothelial cells were conducted on non-small cell lung cancer patients receiving bevacizumab plus chemotherapy.
[Molecular Oncology]
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Using Single-Cell Sequencing Technology to Detect Circulating Tumor Cells in Solid Tumors

Investigators describe the identification, biological characteristics, and single-cell genome-wide variation in circulating tumor cells and summarizes the application of single-cell sequencing technology to tumor typing, metastasis analysis, progression detection, and adjuvant therapy.
[Molecular Cancer]
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ICAM1 Initiates CTC Cluster Formation and Trans-Endothelial Migration in Lung Metastasis of Breast Cancer

ICAM1 expression increased by 200-fold in the lung metastases of three TNBC patient-derived xenografts, and its depletion abrogated lung colonization of TNBC cells by inhibiting homotypic tumor cell-tumor cell cluster formation.
[Nature Communications]
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The Role of Liquid Biopsies in Prostate Cancer Management

Researchers describe recent advancements in isolation and detection technology and the strength and weaknesses of the three circulating biomarkers.
[Lab on a Chip]
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Oxaliplatin Resistance in Colorectal Cancer Enhances TRAIL Sensitivity via Death Receptor 4 Upregulation and Lipid Raft Localization

Scientists demonstrated that oxaliplatin-resistant colorectal cancer cells were sensitized to TRAIL-mediated apoptosis. Oxaliplatin-resistant cells exhibited transcriptional downregulation of caspase-10, but this had minimal effects on TRAIL sensitivity following CRISPR-Cas9 deletion of caspase-10 in parental cells.
[eLife]
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Circulating Tumor Cell Copy-Number Heterogeneity in ALK-Rearranged Non-Small-Cell Lung Cancer Resistant to ALK Inhibitors

Researchers provided in-depth investigation of copy number alteration heterogeneity in phenotypically characterized circulating tumor cells at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors in ALK-positive non-small cell lung cancer.
[npj Precision Oncology]
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Single-Cell microRNA Sequencing Method Comparison and Application to Cell Lines and Circulating Lung Tumor Cells

Scientists evaluated 19 protocols for single cell small RNA sequencing on MCF7 cells spiked with 1 pg of 1,006 miRNAs.
[Nature Communications]
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CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis

The authors assessed whether circulating tumor cells (CTCs) in peripheral blood could serve as a disease surrogate, focusing on CD44 and CD74 expression as prognostic markers for brain metastases.
[International Journal of Molecular Sciences]
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Heterotypic Clustering of Circulating Tumor Cells and Circulating Cancer-Associated Fibroblasts Facilitates Breast Cancer Metastasis

Scientists reported that the dissemination of circulating tumor cells, circulating cancer-associated fibroblasts, and clusters was an early event in breast cancer (BC) progression, and they found these clusters in all clinical stages of BC.
[Breast Cancer Research and Treatment]
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Molecular and Circulating Biomarkers of Brain Tumors

The authors review the available literature on plasma circulating tumor cells, cell-free tumors, circulating cell-free microRNAs, and circulating extracellular vesicles for the diagnosis and monitoring of brain tumor.
[International Journal of Molecular Sciences]
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