Tumor ENPP1(CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

Researchers unveiled the ectonucleotide pyrophosphatase /phosphodiesterase 1 (ENPP1)/HP axis as an unanticipated mechanism exploited by tumor cells linking inflammation to immune remodeling favoring local relapse.
[Cancer Discovery]
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Breast Cancer Circulating Tumor Cells with Mesenchymal Features — an Unreachable Target?

The authors review the clinical significance of mesenchymal circulating tumor cells (CTCs) in breast cancer together with statistical analysis of previously published data, in which they assess the suitability of a number of methods/markers used for isolation of CTCs with different epithelial-mesenchymal transition phenotypes.
[Cellular and Molecular Life Sciences]
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Transcriptomic Profiling of Single Circulating Tumor Cells Provides Insight into Human Metastatic Gastric Cancer

Researchers utilized an antigen-independent strategy for circulating tumor cell (CTC) isolation from metastatic gastric cancer patients involving a size-dependent recovery of CTCs and a single cell isolation technique.
[Communications Biology]
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Alternative Splicing of NF-YA Promotes Prostate Cancer Aggressiveness and Represents a New Molecular Marker for Clinical Stratification of Patients

Researchers indicated that the modulation of NF-YA isoforms affected prostate pathophysiological processes and contributed to a cancer-relevant phenotype, in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research]
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PD-L1 Expression on Circulating Tumor Cells and Platelets in Patients with Metastatic Breast Cancer

Whole blood was collected at serial timepoints from metastatic breast cancer patients and healthy donors for circulating tumor cell and platelet PD-L1 analysis with a phycoerythrin-labeled anti-human PD-L1 monoclonal antibody using the CellSearch® assay.
[PLoS One]
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The Role of Membrane Mucin MUC4 in Breast Cancer Metastasis

Investigators discuss the diverse roles of MUC4 in tumor progression and metastasis, and propose that intervening in MUC4 intercellular interactions with binding partners on blood-borne aggregating cells could potentially thwart breast cancer metastatic efficiency.
[Endocrine-Related Cancer]
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Platelet-Mediated Tumor Metastasis Mechanism and the Role of Cell Adhesion Molecules

Investigators introduce the mechanism of platelet-related tumor metastasis and particularly focus on the role of cell adhesion molecules in it.
[Critical Reviews in Oncology/Hematology]
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Molecular Testing in Breast Cancer: Current Status and Future Directions

The authors provide an overview of currently available molecular assays and testing modalities that have prognostic, predictive, and therapeutic value. These include multi-gene assays for invasive breast cancer and ductal carcinoma in situ, and companion tests to detect PIK3CA mutations and NTRK fusions.
[Journal of Molecular Diagnostics]
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Role of Aneuploid Circulating Tumor Cells and CD31+ Circulating Tumor Endothelial Cells in Predicting and Monitoring Anti-angiogenic Therapy Efficacy in Advanced NSCLC

Co-detection and comprehensive phenotypic and karyotypic molecular characterization of aneuploid circulating tumor cells and circulating tumor endothelial cells were conducted on non-small cell lung cancer patients receiving bevacizumab plus chemotherapy.
[Molecular Oncology]
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Using Single-Cell Sequencing Technology to Detect Circulating Tumor Cells in Solid Tumors

Investigators describe the identification, biological characteristics, and single-cell genome-wide variation in circulating tumor cells and summarizes the application of single-cell sequencing technology to tumor typing, metastasis analysis, progression detection, and adjuvant therapy.
[Molecular Cancer]
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ICAM1 Initiates CTC Cluster Formation and Trans-Endothelial Migration in Lung Metastasis of Breast Cancer

ICAM1 expression increased by 200-fold in the lung metastases of three TNBC patient-derived xenografts, and its depletion abrogated lung colonization of TNBC cells by inhibiting homotypic tumor cell-tumor cell cluster formation.
[Nature Communications]
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