Circulating Tumor Cell Number and Endocrine Therapy Index in ER Positive Metastatic Breast Cancer Patients

Circulating tumor cells enumeration at initiation of endocrine therapy (ET), and at early and following time points was prognostic in ER-positive metastatic breast cancer starting second-line or later ET.
[npj Breast Cancer]
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PELP1/Src-3-Dependent Regulation of Metabolic Pfkfb Kinases Drives Therapy Resistant Er+ Breast Cancer

Researchers showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast cancer stem cell expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.
[Oncogene]
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In Vivo Flow Cytometry Reveals a Circadian Rhythm of Circulating Tumor Cells

Scientists applied fluorescence in vivo flow cytometryto monitor circulating tumor cells noninvasively in an orthotopic mouse model of human prostate cancer.
[Light-Science & Applications]
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Systemic Metastasis-Targeted Nanotherapeutic Reinforces Tumor Surgical Resection and Chemotherapy

Investigators designed a systemic metastasis-targeted nanotherapeutic (H@CaPP) to hinder the multiple steps of tumor metastasis. H@CaPP efficiently inhibited tumor metastasis and prolonged overall survival of 4T1 mammary tumor-bearing mice.
[Nature Communications]
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Progress and Application of Circulating Tumor Cells in Non-small Cell Lung Cancer

Researchers discuss the technologies for detection and enrichment of circulating tumor cells, as well as clinical applications involving circulating tumor cells.
[Molecular Therapy-Oncolytics]
Qian, H., Zhang, Y., Xu, J., He, J., & Gao, W. (2021). Progress and application of circulating tumor cells in non-small cell lung cancer. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.05.005 Cite
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Progress and Application of Circulating Tumor Cells in Non-Small Cell Lung Cancer

Scientists discuss the technologies for detection and enrichment of circulating tumor cells, as well as clinical applications involving circulating tumor cells.
[Molecular Therapy-Oncolytics]
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Clinical Significance of Circulating Tumor Cell Related Markers in Patients with Epithelial Ovarian Cancer Before and after Adjuvant Chemotherapy

Using quantitative real-time PCR, the authors evaluated the expression of EPCAM, MUC1, CEA, HE4 and CA125 mRNAs, as putative markers of circulating tumor cells, in the blood of 51 epithelial ovarian cancer patients before and/or after adjuvant chemotherapy.
[Scientific Reports]
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Bedaquiline, an FDA-Approved Drug, Inhibits Mitochondrial ATP Production and Metastasis In Vivo, by Targeting the Gamma Subunit (ATP5F1C) of the ATP Synthase

Scientists found that Bedaquiline had no effect on the growth of non-tumorigenic mammary epithelial cells or primary tumors in vivo.
[Cell Death & Differentiation]
Fiorillo, M., Scatena, C., Naccarato, A. G., Sotgia, F., & Lisanti, M. P. (2021). Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase. Cell Death & Differentiation, 1–21. https://doi.org/10.1038/s41418-021-00788-x Cite
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Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix

Through structure-activity relationship studies focused on the actin-binding tail region of MycB, scientists identified a potent truncated derivative that inhibits polymerization of G-actin and severs F-actin by binding to actin’s barbed end cleft.
[Journal of the American Chemical Society]
Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix | Journal of the American Chemical Society. (n.d.). Retrieved May 6, 2021, from https://pubs.acs.org/doi/10.1021/jacs.0c12404 Cite
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Prostate Cancer and Microfluids

Investigators show the vast scope and application of microfluidic systems and how these systems will ensure advancements to future prostate cancer management.
[Urologic Oncology: Seminars and Original Investigations]
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Development and Validation for Prognostic Nomogram of Epithelial Ovarian Cancer Recurrence Based on Circulating Tumor Cells and Epithelial–Mesenchymal Transition

Scientists used CanPatrol circulating tumor cells (CTC)-enrichment technique to detect CTCs from blood samples and classify subpopulations into epithelial, mesenchymal, and hybrids.
[Scientific Reports]
Yang, J., Ma, J., Jin, Y., Cheng, S., Huang, S., Zhang, N., & Wang, Y. (2021). Development and validation for prognostic nomogram of epithelial ovarian cancer recurrence based on circulating tumor cells and epithelial–mesenchymal transition. Scientific Reports, 11(1), 6540. https://doi.org/10.1038/s41598-021-86122-4 Cite
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