circulating tumor cells

[Trends in Pharmacological Sciences] Investigators summarize advances in using circulating tumor cell (CTC) enumeration, characterization, and expansion to provide personalized cancer treatment, their limitations, and suggest future areas of study necessary to bring CTC analysis to clinics.

[Journal of Experimental & Clinical Cancer Research] Investigators generated organoids from circulating tumor cells isolated from an orthotopic colorectal cancer xenograft model.

[Biophysical Journal] Investigators noted that circulating tumor cells isolated from prostate cancer patients displayed a specific mechanical phenotype, determined with atomic force microscopy: high softness and high adhesion.

[Biophysical Journal] The authors showed that circulating tumor cells isolated from the blood of prostate cancer patients displayed specific nanomechanical phenotypes characteristic of cell endurance and invasiveness and patient sensitivity to androgen deprivation therapy.

[Cancer Discovery] Researchers unveiled the ectonucleotide pyrophosphatase /phosphodiesterase 1 (ENPP1)/HP axis as an unanticipated mechanism exploited by tumor cells linking inflammation to immune remodeling favoring local relapse.

[Cellular and Molecular Life Sciences] The authors review the clinical significance of mesenchymal circulating tumor cells (CTCs) in breast cancer together with statistical analysis of previously published data, in which they assess the suitability of a number of methods/markers used for isolation of CTCs with different epithelial-mesenchymal transition phenotypes.