circulating tumor cells

[Communications Biology] Researchers utilized an antigen-independent strategy for circulating tumor cell (CTC) isolation from metastatic gastric cancer patients involving a size-dependent recovery of CTCs and a single cell isolation technique.

[Journal of Experimental & Clinical Cancer Research] Researchers indicated that the modulation of NF-YA isoforms affected prostate pathophysiological processes and contributed to a cancer-relevant phenotype, in vitro and in vivo.

[PLoS One] Whole blood was collected at serial timepoints from metastatic breast cancer patients and healthy donors for circulating tumor cell and platelet PD-L1 analysis with a phycoerythrin-labeled anti-human PD-L1 monoclonal antibody using the CellSearch® assay.

[Endocrine-Related Cancer] Investigators discuss the diverse roles of MUC4 in tumor progression and metastasis, and propose that intervening in MUC4 intercellular interactions with binding partners on blood-borne aggregating cells could potentially thwart breast cancer metastatic efficiency.

[Critical Reviews in Oncology/Hematology] Investigators introduce the mechanism of platelet-related tumor metastasis and particularly focus on the role of cell adhesion molecules in it.

[Journal of Molecular Diagnostics] The authors provide an overview of currently available molecular assays and testing modalities that have prognostic, predictive, and therapeutic value. These include multi-gene assays for invasive breast cancer and ductal carcinoma in situ, and companion tests to detect PIK3CA mutations and NTRK fusions.