Versantis Announces Positive Phase Ib Results for VS-01 in Patients with Decompensated Cirrhosis

Versantis announced positive results from a Phase Ib clinical trial of VS-01 in decompensated liver cirrhosis. VS-01 was found to be safe and well tolerated in this first-in-human, single ascending and multiple dose study led by Prof. Dr. Jonel Trebicka at the Goethe University Hospital Frankfurt.
[Versantis]
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Immunotherapy for Recurrent Glioblastoma: Practical Insights and Challenging Prospects

The authors describe the immunosuppressive molecular characteristics of recurrent glioblastoma; clinical trials exploring anti-PD-1/PD-L1 therapy, tumor-specific peptide vaccination, and CAR-T cell therapy; candidate combination strategies; and issues related to strengthening T cell function.
[Cell Death & Disease]
Wang, X., Lu, J., Guo, G., & Yu, J. (2021). Immunotherapy for recurrent glioblastoma: practical insights and challenging prospects. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03568-0 Cite
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Lustgarten Foundation Receives $424,000 Grant Establishing the Gail V. Coleman and Kenneth M. Bruntel Organoids for Personalized Therapy Project

Funded in part by a $424,000 gift establishing the Gail V. Coleman and Kenneth M. Bruntel Organoids for Personalized Therapy Grant, organoid analysis has been included in an upcoming clinical trial to determine if the organoid response to drugs in the lab can accurately predict which chemotherapy will be most effective for each patient.
[Lustgarten Foundation Pancreatic Cancer Foundation]
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Anokion Announces Initiation of Multiple-Ascending Dose Portion of its Phase I Clinical Trial with KAN-101 for the Treatment of Celiac Disease

Anokion SA announced that the company has initiated patient dosing in the multiple ascending dose portion of its Assessment of KAN-101 in Celiac Disease disease, a Phase I clinical trial evaluating KAN-101 for the treatment of individuals with celiac disease.
[Anokion SA]
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Celcuity Announces Breast Cancer Clinical Trial Collaboration with MD Anderson, Novartis, and Puma Biotechnology to Study New Drug Regimen

Celcuity, Inc. announced a clinical trial collaboration with the MD Anderson Cancer Center, Novartis AG, and Puma Biotechnology, Inc., to conduct a Phase II clinical trial. This open-label Phase II trial will evaluate the efficacy and safety of two targeted therapies, TABRECTA®, a c-Met inhibitor, and NERLYNX® a pan-HER inhibitor, in patients with previously treated metastatic HER2-negative breast cancer.
[Celcuity, Inc.]
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PEP-Therapy and Institut Curie Granted Approval from ANSM to Start First-Inhuman Clinical Trial of PEP-010 for the Treatment of Advanced Solid Tumors

PEP-Therapy and Institut Curie, announced that they have been granted approval from the French National Agency for Medicines and Health Products (ANSM) to proceed with the first-in-human clinical trial of PEP-Therapy’s lead drug candidate, PEP-010.
[PEP-Therapy]
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Rubius Therapeutics Reports Initial Clinical Data from Ongoing Phase I/II Trial of RTX-240 in Patients with Advanced Solid Tumors, Demonstrating Single-Agent Activity

Rubius Therapeutics, Inc. announced initial clinical, pharmacodynamic and tumor trafficking data from its ongoing Phase I/II clinical trial of RTX-240 in patients with advanced solid tumors.
[Rubius Therapeutics, Inc.]
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AVEO Oncology Announces Collaboration with Bristol Myers Squibb to Evaluate FOTIVDA® (Tivozanib) in Combination with OPDIVO® (Nivolumab) in Pivotal Phase III TiNivo-2 Trial in IO Relapsed Renal Cell Carcinoma

AVEO Oncology announced that it has entered into a clinical trial collaboration and supply agreement with Bristol Myers Squibb to evaluate FOTIVDA® in combination with OPDIVO®, Bristol Myers Squibb’s anti-PD-1 therapy, in the pivotal Phase III TiNivo-2 trial in patients with advanced relapsed or refractory renal cell carcinoma following prior immunotherapy exposure.
[AVEO Oncology]
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LI Cancer Patient First in NYS to Receive Aerosolized Chemotherapy Treatment

Long Island Jewish (LIJ) Medical Center, in collaboration with the Northwell Health Cancer Institute, is testing the efficacy of delivering aerosolized chemotherapy to patients who currently have few treatment options, the second such clinical trial site in the nation.
[Long Island Jewish (LIJ) Medical Center]
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Functional Expression of Complement Factor I Following AAV-Mediated Gene Delivery in the Retina of Mice and Human Cells

Scientists demonstrated the generation of AAV constructs carrying the human Complement Factor I (CFI) sequence and expression of CFI in cell lines and in the retina of C57BL/6 J mice.
[Gene Therapy]
Dreismann, A. K., McClements, M. E., Barnard, A. R., Orhan, E., Hughes, J. P., Lachmann, P. J., & MacLaren, R. E. (2021). Functional expression of complement factor I following AAV-mediated gene delivery in the retina of mice and human cells. Gene Therapy, 1–12. https://doi.org/10.1038/s41434-021-00239-9 Cite
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Longitudinal Neuroimaging Evaluation of the Corticospinal Tract in Patients with Stroke Treated with Autologous Bone Marrow Cells

Scientists imaged 37 patients with stroke, 17 patients treated with mononuclear cells and 20 patients who received standard of care.
[STEM CELLS Translational Medicine]
Haque, M. E., Hasan, K. M., George, S., Sitton, C., Boren, S., Arevalo, O. D., Vahidy, F., Zhang, X., Cox, C. S., Alderman, S., Aronowski, J., Grotta, J. C., & Savitz, S. I. (n.d.). Longitudinal neuroimaging evaluation of the corticospinal tract in patients with stroke treated with autologous bone marrow cells. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0369 Cite
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