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colony growth

Trefoil Factor 3 Promotes Pancreatic Carcinoma Progression via WNT Pathway Activation Mediated by Enhanced WNT Ligand Expression

[Cell Death & Disease] Researchers observed that trefoil factor 3 (TFF3) expression was elevated in PDAC, and was positively correlated with a worse overall patient survival outcome.

OLFM4-RET Fusion Is an Oncogenic Driver in Small Intestine Adenocarcinoma

[Oncogene] Researchers investigated the biological effects of OLFM4-RET fusion and whether it could initiate tumorigenesis in small intestine.

Membrane Translocation and Activation of GnRH Receptor Sensitize Prostate Cancer Cells to Radiation

[International Journal of Radiation Biology] Scientists evaluated the effect of radiation on prostate cancer cells pretreated with leuprolide, alone or in combination with IN3, as radiosensitizers.

Type I Collagen Promotes Tumor Progression of Integrin β1 Positive Gastric Cancer through a BCL9L/β-Catenin Signaling Pathway

[Aging] In vitro, researchers found that 3D collagen culture promoted the capability of colony formation and growth in integrin β1 positive gastric cancer, whereas limited colony growth was observed in ITGB1 negative gastric cancer, suggesting the role of ITGB1 in type I collagen associated tumor progression.

Nuclear βArrestin1 Regulates Androgen Receptor Function in Castration Resistant Prostate Cancer

[Oncogene] Scientists identified ubiquitous βArrestin 1 as a regulator of androgen receptor function in castration-resistant prostate cancer.

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