Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines

The toxicity of Gemini-Cur on HT-29 and HCT116 was studied through MTT, uptake kinetics, fluorescence microscopy, annexin V/FITC, and cell cycle assays.
[International Journal of Pharmaceutics]
Ebrahimi, M., Babaei, E., Neri, F., & Feizi, M. A. H. (2021). Anti-proliferative and apoptotic effect of gemini curcumin in p53-wild type and p53-mutant colorectal cancer cell lines. International Journal of Pharmaceutics, 601, 120592. https://doi.org/10.1016/j.ijpharm.2021.120592 Cite
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Morphological and Molecular Characteristics of Spheroid Formation in HT-29 and Caco-2 Colorectal Cancer Cell Lines

Colorectal cancer spheroids were developed using hanging drop and forced floating in serum-free and non-attachment conditions and their morphological features were evaluated by scanning electron microscopy.
[Cancer Cell International]
Gheytanchi, E., Naseri, M., Karimi-Busheri, F., Atyabi, F., Mirsharif, E. S., Bozorgmehr, M., Ghods, R., & Madjd, Z. (2021). Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines. Cancer Cell International, 21(1), 204. https://doi.org/10.1186/s12935-021-01898-9 Cite
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GPR126 Regulates Colorectal Cancer Cell Proliferation by Mediating HDAC2 and GLI2 Expression

Investigators found that GPR126 had higher expression in most colorectal cancer cell lines than in normal colon epithelial cell lines, and higher expression levels in colorectal cancer tissues than in normal adjacent colon tissues.
[Cancer Science]
Cui, H., Yu, W., Yu, M., Luo, Y., Yang, M., Cong, R., Chu, X., Gao, G., & Zhong, M. (n.d.). GPR126 regulates colorectal cancer cell proliferation by mediating HDAC2 and GLI2 expression. Cancer Science, n/a(n/a). https://doi.org/https://doi.org/10.1111/cas.14868 Cite
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Autophagy Inhibitors Increase the Susceptibility of KRAS-Mutant Human Colorectal Cancer Cells to a Combined Treatment of 2-deoxy-D-glucose and Lovastatin

A combination of lovastatin and 2-deoxy-D-glucose synergistically reduced cell viability, arrested cells in the G2/M phase, and induced apoptosis. The combined treatment also reduced cellular oxygen consumption and extracellular acidification rate, resulting in decreased production of ATP and lower steady-state ATP levels.
[Acta Pharmacologica Sinica]
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An Autoregulatory Feedback Loop of miR-21/VMP1 Is Responsible for the Abnormal Expression of miR-21 in Colorectal Cancer Cells

Scientists found that the expression of miR-21 was negatively correlated with the expression of vacuole membrane protein-1 (VMP1) in colorectal cancer. Transcription of VMP1 activated either by small activating RNA or transcriptional activator GLI3 inhibited miR-21 expression through reducing its transcripts of VMP1-miR-21 and pri-miR-21, while no significant change in miR-21 expression after exogenous overexpression VMP1 in colorectal cancer cell HCT116.
[Cell Death & Disease]
Wang, C., Peng, R., Zeng, M., Zhang, Z., Liu, S., Jiang, D., Lu, Y., & Zou, F. (2020). An autoregulatory feedback loop of miR-21/VMP1 is responsible for the abnormal expression of miR-21 in colorectal cancer cells. Cell Death & Disease, 11(12), 1–14. https://doi.org/10.1038/s41419-020-03265-4 Cite
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Molecular Subtype-Specific Responses of Colon Cancer Cells to the SMAC Mimetic Birinapant

Responses to the inhibitor of apoptosis protein antagonist Birinapant and oxaliplatin/5-fluorouracil were investigated in 14 colon cancer cell lines, representing the consensus molecular subtypes.
[Cell Death & Disease]
Fichtner, M., Bozkurt, E., Salvucci, M., McCann, C., McAllister, K. A., Halang, L., Düssmann, H., Kinsella, S., Crawford, N., Sessler, T., Longley, D. B., & Prehn, J. H. M. (2020). Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant. Cell Death & Disease, 11(11), 1–16. https://doi.org/10.1038/s41419-020-03232-z Cite
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APC Regulation of ESRP1 and p120-Catenin Isoforms in Colorectal Cancer Cells

This report describes the effects of full-length, wild-type APC (fl-APC) on cell-cell adhesion genes and p120-catenin isoform switching in SW480 colon cancer cells: fl-APC increased the expression of genes implicated in cell-cell adhesion, whereas the expression of negative regulators of E-cadherin were decreased.
[Molecular Biology of the Cell]
Faux, M. C., King, L. E., Kane, S. R., Love, C., Sieber, O. M., & Burgess, A. W. (2020). APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells. Molecular Biology of the Cell, mbc.E20-05-0321. https://doi.org/10.1091/mbc.E20-05-0321 Cite
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Manipulating the Tumor Microenvironment in Tumor Organoids Induces Phenotypic Changes and Chemoresistance

Investigators used a tumor organoid model, consisting of hepatic stellate cells embedded in Collagen-1 (Col1) and colorectal cancer cell (HCT-116) spheroids, to determine the relationship between the ECM architecture, cancer cell malignancy, and chemoresistance.
[iScience]

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The POLD1R689W Variant Increases the Sensitivity of Colorectal Cancer Cells to ATR and CHK1 Inhibitors

Using CRISPR/Cas9 in the colorectal cancer cell line DLD-1, which harbors four POLD1 variants, scientists established heterozygous POLD1-knockout clones with exclusive expression of distinct variants to determine the functional relevance of these variants individually by assessing their impact on ATR pathway activation, DNA replication, and cellular sensitivity to inhibition of ATR or its effector kinase CHK1.
[Scientific Reports]
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Epigenetic Activation of the Small GTPase TCL Contributes to Colorectal Cancer Cell Migration and Invasion

Myocardin-related transcription factor A (MRTF-A) promoted migration and invasion of HT-29 cells in a TC10-like (TCL)-dependent manner. MRTF-A directly bound to the proximal TCL promoter in response to hypoxia to activate TCL transcription.
[Oncogenesis]
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Berberine Inhibits Colorectal Tumor Growth by Suppressing SHH Secretion

Berberine promotes the degradation of SHH mRNA in colorectal cancer cells, interrupting the paracrine Hedgehog signaling pathway activity thus suppresses the colorectal cancer growth.
[Acta Pharmacologica Sinica]
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