Combination of Resveratrol and BIBR1532 Inhibits Proliferation of Colon Cancer Cells by Repressing Expression of LncRNAs

Scientists investigated the effect of resveratrol and BIBR1532, either alone or in combination, on the cell viability as well as on expression of long non-coding RNAs for HT-29 colon adenocarcinoma cells.
[Medical Oncology]
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Ring Finger 220 Promotes the Stemness and Progression of Colon Cancer Cells via Ubiquitin Specific Peptidase 22-BMI1 Axis

Investigators found that RNF220 was upregulated in colorectal cancer in patients and cell models. RT-PCR assay was used to compare differences between expression levels of RNF220 in colorectal tumor and normal tissues.
[Bioengineered]
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miR-3065-3p Promotes Stemness and Metastasis by Targeting CRLF1 in Colorectal Cancer

The expression of miR-3065-3p in colorectal cancer and the association of miR-3065-3p expression with prognosis of patients with colorectal cancer were analyzed using TCGA dataset or clinical cases.
[Journal of Translational Medicine]
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Musarin, a Novel Protein with Tyrosine Kinase Inhibitory Activity from Trametes versicolor, Accepted Inhibits Colorectal Cancer Stem Cell Growth

Researchers characterized a novel 12-kDa protein that named musarin, which was purified from Trametes versicolor mushroom extract and showed significant growth inhibition on multiple human colorectal cancer cell lines in vitro.
[Biomedicine & Pharmacotherapy]
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NeuroD1 Promotes Tumor Cell Proliferation and Tumorigenesis by Directly Activating the Pentose Phosphate Pathway in Colorectal Carcinoma

Scientists reported that neurogenic differentiation factor 1 (NeuroD1) was positively correlated with glucose-6-phosphate dehydrogenase, the rate-limiting enzyme in the pentose phosphate pathway, in colorectal cancer cells.
[Oncogene]
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p27kip1 Expression and Phosphorylation Dictate Palbociclib Sensitivity in KRAS-Mutated Colorectal Cancer

Researchers investigated the role of the CDK inhibitor p27kip1 in the response to the selective CDK4/6-inhibitor Palbociclib, in colorectal cancer.
[Cell Death & Disease]
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Podophyllotoxin Induces ROS-Mediated Apoptosis and Cell Cycle Arrest in Human Colorectal Cancer Cells via p38 MAPK Signaling

Researchers evaluated the anticancer effect of Podophyllotoxin on human colorectal cancer HCT116 cells and identified the detailed molecular mechanism.
[Biomolecules & Therapeutics]
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Suppression of Autophagy Promotes Fibroblast Activation in p53-Deficient Colorectal Cancer Cells

Researchers aimed to clarify the significance of autophagy in fibroblasts, focusing on the TP53 status in co-cultured human colorectal cancer cell lines in vitro.
[Scientific Reports]
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Picropodophyllotoxin Induces G1/S Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway

Scientists explored the anticancer activity and its underlying mechanisms of PPT in HCT116 cells. The MTT assay was used to monitor the cell viability.
[World Journal of Microbiology & Biotechnology]
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Polyplexes of Retinoic Acid: An In Vitro Study of Complex Nanostructures against Colorectal Cancer Cell Line (HCT-15)

Cell line studies of the formulation displayed better cell inhibition and low cytotoxicity for the retinoic acid-loaded polyplexes in comparison to pure retinoic acid, thus demonstrating better potential action against colorectal cancer cell line HCT-15.
[Journal of Materials Science-Materials in Medicine]
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RAS Specific Protease Induces Irreversible Growth Arrest via p27 in Several KRAS Mutant Colorectal Cancer Cell Lines

Researchers demonstrated, using isogenic mouse fibroblasts expressing a single isoform of RAS or mutant KRAS, that RAS/RAP1-specific endopeptidase equally inactivated all isoforms of RAS as well as the major oncogenic KRAS mutants.
[Scientific Reports]
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