colorectal cancer cells

[IUBMB Life] Scientists determined the epigenetic features of the HNF1A gene loci, and expression and cellular localization of HNF1A-AS1 RNA, HNF1A RNA, and HNF1A protein in colorectal cancer and normal colon epithelial cells.

[Oncology Reports] In vitro, the AZD6738/5‑FU combination increased the number of mitotic cells according to flow cytometry, decreased the checkpoint kinase 1 phosphorylation levels and increased cleaved caspase‑3 and phosphorylated form of H2A.X variant histone levels according to western blotting, and decreased the proliferation rate of four colon cancer cell lines according to cell viability experiments.

[Scientific Reports] The authors determined if mouse hepatic progenitor cells — oval cells (OCs) — were susceptible to incorporate Kras GAT mutation from mouse colorectal cancer cell line CT26.WT and if OCs with the incorporated mutation behaved like malignant cells.

[Advanced Science] The authors showed that Fusobacterium nucleatum promoted colorectal cancer stem-like cells (CCSCs) self-renewal, and non-CCSCs to acquire CCSC features by manipulating cellular lipid accumulation.

[Cell Death & Disease] PTBP3 knockdown in colorectal cancer cell lines restricted colorectal cancer proliferative capacities in vitro and in vivo.

[Scientific Reports] Scientists explored the role of cancer cell-derived amphoterin-induced gene and open reading frame 2 (AMIGO2)-containing extracellular vesicles in the adhesion of cancer cells to human hepatic sinusoidal endothelial cells.