MicroRNA-17-5p Regulates EMT by Targeting Vimentin in Colorectal Cancer

The authors demonstrated that miRNA-17-5p regulated vimentin expression, thereby regulating metastasis of colorectal cancer.
[British Journal of Cancer]
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BRAF Mutated Colorectal Cancer: New Treatment Approaches

The authors study the biology of a subgroup of colon cancer harboring a BRAF mutation, to understand the current approach in clinical research.
[Cancers]
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Simulating the Human Colorectal Cancer Microenvironment in 3D Tumor-Stroma Co-Cultures In Vitro and In Vivo

Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[Scientific Reports]
Devarasetty, M., Dominijanni, A., Herberg, S., Shelkey, E., Skardal, A., & Soker, S. (2020). Simulating the human colorectal cancer microenvironment in 3D tumor-stroma co-cultures in vitro and in vivo. Scientific Reports, 10(1), 9832. https://doi.org/10.1038/s41598-020-66785-1 Cite
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SphK2 Confers 5-Fluorouracil Resistance to Colorectal Cancer via Upregulating H3K56ac-Mediated DPD Expression

Investigators showed that SphK2high conferred 5-fluorouracil resistance through upregulated tumoral dihydropyrimidine dehydrogenase.
[Oncogene]
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Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma

The authors address the recent advances in in vitro colorectal carcinoma (CRC) model systems, ranging from conventional CRC patient-derived models, such as conditional reprogramming-based cell cultures, to more experimental and state-of-the-art models, such as cancer-on-chip platforms or liquid biopsy.
[Cancers]
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ROS-Mediated Apoptotic Cell Death of Human Colon Cancer LoVo Cells by Milk δ-Valerobetaine

Scientists tested the antineoplastic properties of milk δVB on human colorectal cancer cells.
[Scientific Reports]
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