Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
Devarasetty, M., Dominijanni, A., Herberg, S., Shelkey, E., Skardal, A., & Soker, S. (2020). Simulating the human colorectal cancer microenvironment in 3D tumor-stroma co-cultures in vitro and in vivo. Scientific Reports, 10(1), 9832. https://doi.org/10.1038/s41598-020-66785-1Cite
The authors address the recent advances in in vitro colorectal carcinoma (CRC) model systems, ranging from conventional CRC patient-derived models, such as conditional reprogramming-based cell cultures, to more experimental and state-of-the-art models, such as cancer-on-chip platforms or liquid biopsy.