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colorectal cancer cells

miR-3065-3p Promotes Stemness and Metastasis by Targeting CRLF1 in Colorectal Cancer

[Journal of Translational Medicine] The expression of miR-3065-3p in colorectal cancer and the association of miR-3065-3p expression with prognosis of patients with colorectal cancer were analyzed using TCGA dataset or clinical cases.

NeuroD1 Promotes Tumor Cell Proliferation and Tumorigenesis by Directly Activating the Pentose Phosphate Pathway in Colorectal Carcinoma

[Oncogene] Scientists reported that neurogenic differentiation factor 1 (NeuroD1) was positively correlated with glucose-6-phosphate dehydrogenase, the rate-limiting enzyme in the pentose phosphate pathway, in colorectal cancer cells.

Podophyllotoxin Induces ROS-Mediated Apoptosis and Cell Cycle Arrest in Human Colorectal Cancer Cells via p38 MAPK Signaling

[Biomolecules & Therapeutics] Researchers evaluated the anticancer effect of Podophyllotoxin on human colorectal cancer HCT116 cells and identified the detailed molecular mechanism.

p27kip1 Expression and Phosphorylation Dictate Palbociclib Sensitivity in KRAS-Mutated Colorectal Cancer

[Cell Death & Disease] Researchers investigated the role of the CDK inhibitor p27kip1 in the response to the selective CDK4/6-inhibitor Palbociclib, in colorectal cancer.

Suppression of Autophagy Promotes Fibroblast Activation in p53-Deficient Colorectal Cancer Cells

[Scientific Reports] Researchers aimed to clarify the significance of autophagy in fibroblasts, focusing on the TP53 status in co-cultured human colorectal cancer cell lines in vitro.

Picropodophyllotoxin Induces G1/S Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway

[World Journal of Microbiology & Biotechnology] Scientists explored the anticancer activity and its underlying mechanisms of PPT in HCT116 cells. The MTT assay was used to monitor the cell viability.

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