colorectal cancer

[Current Medicinal Chemistry] Researchers investigated the effects of curcumin treatment on cisplatin-resistant colorectal cancer cells. Expression levels of miRNAs and mRNAs were determined by qRT-PCR. Protein expression levels were detected by Western blotting.

[Molecular Biology Reports] IL-21 has profound effects on tumor growth and immunosurveillance of colitis-associated tumourigenesis, thereby emphasising its involvement in the pathogenesis of colorectal cancer.

[Biochemical and Biophysical Research Communications] A small molecule EHMT-2 inhibitor, BIX-01294, was evaluated for its activity in inhibiting cancer stem cells in human colorectal cancer by in vitro and in vivo experiments.

[ISME Journal] Researchers showed that propionate suppressed colorectal cancer growth by promoting the proteasomal degradation of euchromatic histone-lysine N-methyltransferase 2 (EHMT2) through HECT domain E3 ubiquitin protein ligase 2 (HECTD2) upregulation.

[International Journal of Oncology] The expression and effect of miR‑1291 in colorectal cancer cells (CRC) was investigated. It was identified that miR‑1291 significantly suppressed the proliferation, invasion, cell mobility and colony formation of CRC cells.

[DNA and Cell Biology] Scientists analyzed the effects of Ginkgo biloba extract (GBE) administration on TET2 expression in human colorectal cancer (CRC). To investigate the expression profiles of TET2, GBE was used to treat CRC cells.