colorectal cancer

[Stem Cell Research & Therapy] The authors review the recent research advances of therapies based on the mesenchymal stem cells-Exo for treating ulcerative colitis and colorectal cancer.

[Biomedicine & Pharmacotherapy] Sphaerococcenol A capacity to impact colorectal-CSCs tumorspheres was evaluated by determining tumorspheres viability, number, and area, as well as the proteasome inhibitory activity.

[Cell Death & Disease] Researchers constructed colorectal cancer PDOs and selected the Kruppel-like factor 5 (KLF5) inhibitor ML264 as the research object based on the results of an in vitro drug screening assay.

[Nature Communications] Investigators examined tumor-immune eco-evolutionary dynamics from pre-cancer to carcinoma using a computational model, ecological analysis of digital pathology data, and neoantigen prediction in 62 patient samples.

[Scientific Reports] Using MRI, scientists determined the correlation between glutamine uptake and the distribution of glutamine transporters, namely ASCT2 and SLC38A2, glutaminase, and CSC markers, such as CD44 and CD166, in a mouse xenograft model of HT29 human colorectal cancer cells.

[Oncogene] Scientists investigated whether IL-36 cytokines play a role in the pathogenesis of colon cancer.