colorectal cancer

[Translational Oncology] Researchers performed a label-free proteomic analysis of exosomes from a pair of homologous human colorectal cancer cell line with different metastatic abilities.

[Frontiers in Molecular Biosciences] In vitro genetic ablation of golgi phosphoprotein 3 (GOLPH3) was performed using small interfering RNA transfection, and a stably overexpressed GOLPH3 colon cancer cell line was constructed using the lentivirus system.

[Nature Chemical Biology] To gain insights into the pharmacobiology of human colorectal cancer, scientists created a robust drug screening platform for patient-derived colorectal organoids.

[Cell Host & Microbe] Scientists discuss recent studies on the involvement of gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis along with human omics data to provide prospective insights into future prevention and treatment of Inflammatory bowel disease and colorectal cancer.

[Stem Cell Reports] Scientists identified miR-148a as a targetable element upstream of pregnane X receptor (PXR) signaling in CSCs, which when over-expressed decreased PXR expression and impaired tumor relapse after chemotherapy in mouse tumor xenografts.

[Nature Communications] Researchers uncovered that Fusobacterium nucleatum induced a dramatic decline of m6A modifications in CRC cells and patient-derived xenograft tissues by downregulation of an m6A methyltransferase METTL3, contributing to inducation of CRC aggressiveness.